DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mop and Ptprz1

DIOPT Version :9

Sequence 1:	NP_648722.2	Gene:	mop / 39610	FlyBaseID:	FBgn0036448	Length:	1833	Species:	Drosophila melanogaster
Sequence 2:	XP_006505075.1	Gene:	Ptprz1 / 19283	MGIID:	97816	Length:	2318	Species:	Mus musculus

Alignment Length:	2237	Identity:	423/2237 - (18%)
Similarity:	711/2237 - (31%)	Gaps:	770/2237 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 MACTHFQAAA---WAYGELRERYANVNGGGDFMTPELLVFQQQ-------VCFAQAQECI----- 188
            :||.......   ||||..|::...|...|...|..|   .|:       :|.:..|..|
Mouse     8 LACVQLLCLCRLDWAYGYYRQQRKLVEEIGWSYTGAL---NQKNWGKKYPICNSPKQSPINIDED 69

  Fly   189 ---------------LEKSLIDNRKPHIVAKVTAQIVV---YYGAALAALLTGGDDGPVAQVIDS 235
                           .||:.::|...|...| |.:|.:   ||       |:||        :..
Mouse    70 LTQVNVNLKKLKFQGWEKASLENTFIHNTGK-TVEINLTNDYY-------LSGG--------LSE 118

  Fly   236 SVYKLWKKYVRFKINYLTCILYLYQGQHSEEKRQMGERVTLYQASWDKLEEARKESKGLPDQRE- 299
            .|:|..|    ...::..|.:.....:||.|.::....:.:|....|:.....:..||....|.
Mouse   119 KVFKASK----ITFHWGKCNVSSEGSEHSLEGQKFPLEMQVYCFDADRFSSFEEAVKGKGRLRAL 179

  Fly   300 -------INESLSFTA--DVVEAKRKNAKNE--NEFIYHEAVPELSTIAAVQGANL--------V 345
                   :.|:|.:.|  |..|:..:..|..  :.|:....:|..:....:...:|        |
Mouse   180 SILFEVGVEENLDYKAIIDGTESVSRFGKQAALDPFVLQNLLPNSTDKYYIYNGSLTSPPCTDTV 244

  Fly   346 NGIGFQ----VSDEEHAGPDIFARLVPMKAHEASSL-------YSEEKAKLLRKYGALLEEKDTQ 399
            ..|.|:    :|:.:.|   :|..::.|:......|       :.|::.|..|:..:....|: :
Mouse   245 EWIVFKDTVSISESQLA---VFCEVLTMQQSGYVMLMDYLQNNFREQQYKFSRQVFSSYTGKE-E 305

  Fly   400 LESYMSSLTLDNLNINEEQANKL------PQGIVDRC--------AALNANKTA----------- 439
            :...:.|...:|:..:.|....|      |:.:.|..        ..|..|..|
Mouse   306 IHEVVCSSEPENVQADPENYTSLLVTWERPRVVYDAMIEKFAVLYQPLAGNDQAKHEFLTDGYQD 370

  Fly   440 ----ISDLVEAMSQLAEITADVETNL-GEISSMLEAEAKAE-----------------------R 476
                :::|:..||.:.:|.|.....| |:.|..|..:...|                       :
Mouse   371 LGAILNNLLPNMSYVLQIVAVCSNGLYGKYSDQLIVDMPTEDAELDLFPELIGTEEIIKEEEYGK 435

  Fly   477 EFQSATGV----------------QRTPNAHITELSREFQKYSEAHAR---------AGESN--N 514
            :.:..||:                |.:...|...:.   .||:||...         :|:|:  |
Mouse   436 DNEEDTGLNPGRDSVTNQIRKKEPQVSTTTHYNHMG---TKYNEAKTNRSPTRGSEFSGKSDVPN 497

  Fly   515 TLRKAMSLHVNNLKI---LARP------LP--EIQQLMPKLSSELNTTEIFRDVKL-----ILNK 563
            |...:.|.||...:.   ::.|      ||  .::.....|:|...|..||..:.|     .||.
Mouse   498 TSPNSTSQHVAEFETERGISLPSQTGTNLPPHNVEGTSASLNSGSKTLFIFPQMNLSGTAESLNT 562

  Fly   564 V--NEMK------AQRAQFHADLRIAINEDDITGKVIAHGGQEGLQALFATELGKHDKITELLDQ 620
            |  .|.|      ::...|..|.::....||.:|     .........|:::...|..||
Mouse   563 VPITEYKEVSADVSEEENFLTDFKLDTGADDSSG-----SSPSTSTVPFSSDNLSHGYIT----- 617

  Fly   621 NMVAQGNILQALTENYAKAAPVLKTLQDVKQKREHFYSSLAASYDVYEDLLAKSAKGLEFYKKLA 685
                ..::.:|:|.:..|........:|         |:.:.|.:..:|            ..|.
Mouse   618 ----SSDMPEAITYDVLKPGSTRNAPED---------SAPSGSEESLKD------------PSLE 657

  Fly   686 GNVQKLLTRFRSARDV--QSEERQQRMQSVKAATTPVVSKPIAETT----PVPAVSSTPKLRDYL 744
            |:|.     |..:.|:  |||....|...::..:|.:......|||    |...||..|.:.|
Mouse   658 GSVW-----FPGSTDLTTQSETGSGRESFLQVNSTDIQIDESRETTESFSPDATVSQDPSVTD-- 715

  Fly   745 KAKAAMADASNPAYVPT-VRPVPVGSENPTQAACSYATAPPNEP---PPPYSLTQQQYFDPSAAG 805
               ..|...|..||:|| |.|              .|..|.:.|   .|..::...|
Mouse   716 ---MGMPHYSTFAYLPTEVTP--------------QAFTPSSRPLDLAPTINILHSQ-------- 755

  Fly   806 YTNPMYQQQQQHIAPPAYKAQASP-------NSQTLHGALGQMNLQGQSQDNNQAGMAYNYGYPS 863
            .|.|:|..:..  ..|:|.::..|       ::|||:
Mouse   756 TTQPVYNGETP--LQPSYSSEVFPLATPLLLDNQTLN---------------------------- 790

  Fly   864 GSVPPLAYAPPGTVPASSASQGLNIQQPLYVATSGNPVS----VSNPSELPSTLQAPFVVNPMSN 924
                        |.||:|:|..         |....|||    ||..|.|.|...||.:
Mouse   791 ------------TTPAASSSDS---------ALHATPVSPSVGVSFESILSSYDDAPLL------ 828

  Fly   925 PYQTAAGYSGQAYQQVNAQAQ---QVT-----------------------------YPTAPSGSS 957
            |: ::|.:|.:.::.::..:|   |||                             |....|..:
Mouse   829 PF-SSASFSSEMFRHLHTVSQTLPQVTSAAERDELSLHASLLVARGDLLLEPSLVQYSDVASHQA 892

  Fly   958 TGQSAQQPLGYAPSQGPQQQAGGYPQSQTPQQQV--GAYQQQPLSGYAQQLTPQQQT-GYSQS-- 1017
            |.::|...||:........:.....|.::|:..|  .||...|...|..:.:....| .||.:
Mouse   893 TTRAASDTLGFGSESAVFYKTSMVSQIESPRSDVVMHAYSSGPEPSYTVEGSHHVPTVSYSSAMP 957

  Fly  1018 ---------QAPQLQAPSYAQNQQS---TGQAQQQQTGYPQTPQQHLAG-----YAQSQQQ---- 1061
                     |...|..||:....:|   |..|...|      |...|:|     .|.|..:
Mouse   958 LHGSVDVSDQGSLLINPSHISMPESSFITPTASLLQ------PPPALSGDGEWSGASSDSELLLP 1016

  Fly  1062 -ATGY-------PQSQTSQQQTTGYSQSQTPQQPLAYQQQPSGYPQQQQQQSLA----PQQPSLY 1114
             |.|.       |.|......||  |......:||:..:...|...:.:..|.:    |.:.::.
Mouse  1017 DADGLRTLNISSPVSVAEFTYTT--SVFADGIKPLSKSEMMYGNETELKMSSFSDMAYPSKSTVV 1079

  Fly  1115 P---------SQAVQASPQPIPGQQATPPNAGQPLPYPQQYTDPNAAPAPAPGVSSVPSPVPVPT 1170
            |         |::::.:...|...::..|   :.|.||       .......|||.||..:....
Mouse  1080 PKMSDVVHKWSESLKETSVSISSMKSVFP---ESLVYP-------TTKGFEQGVSHVPEIIFPVQ 1134

  Fly  1171 PAPTSSQAQVPT------SPHPSATYTSYSN----HPGYSFNPQTGKYEYSSGYQQDTSSLKGSQ 1225
            |..|:|||...|      |.:..|.::..::    ||    :.|...||.::.:..:.......|
Mouse  1135 PTHTASQASGDTWLKPGLSANSEAAFSDTASREVVHP----STQPLLYEAATPFNTEALLQPSFQ 1195

  Fly  1226 ASQSYQFSQSG---------------KQQSVGTTDSEIASRSNTATG---FDS-PI--VSHTKVN 1269
            ||......::.               .:||..:....:||.|.::..   |.| ||  :|.:||:
Mouse  1196 ASDVDTLLKTALPSVPSDPILAGTPQVEQSSSSVSHPMASESGSSESMLHFTSVPILDISPSKVH 1260

  Fly  1270 MAAKDSTSAIEG---NESSNYYSTPYGYLGSVNPQQ-----------------------QP---- 1304
                  ::.::|   ..||..:| ..|.|.|.:|||                       .|
Mouse  1261 ------STPLQGLTVPHSSKKFS-EQGLLKSKSPQQVLPSLFSNDEFFQSAHLDVSQAYPPKGRH 1318

  Fly  1305 ---TPA----PPSNSTAS--IYMQSGASSTAETQT-----------------TSSGVPYASS-AA 1342
               ||.    .|.|:..:  :|.:...|||..:.|                 |...||..|. .:
Mouse  1319 AFVTPVLSIDEPQNTLINKLVYSEDIFSSTEISITDKVLTGLPTLASDVLSSTDHSVPLGSGPIS 1383

  Fly  1343 LTKVEPK------------PEALPPKVT----SNVDLL------SDLDID--------------C 1371
            ||.|.|.            |.....|:|    |:.||:      .|.|.|              |
Mouse  1384 LTMVSPNRDDSVTTAKLLLPSTATSKLTQSARSDADLVGGGEDGDDYDDDDYDDIDRGRFPVNKC 1448

  Fly  1372 SVAVPPPMLPQPVL-----QPQVVATPTPPASQVSVPVKVESVAEH----------AAPATAEIP 1421
            ...:|.....:.|:     |...:...:.|.|    |:..|:..|.          .:|..:.:|
Mouse  1449 MSCLPYRESREKVMNDSDTQESSLVDQSDPIS----PLLFENTEEENGGTGVTRVDKSPPPSMLP 1509

  Fly  1422 VAATEGTAQTPVTIPS-------GPKC-----------------ASLDNLSNCSDLS--SLENFD 1460
            ....:|...:.:.:.|       |.|.                 .||::....:|.|  .:...|
Mouse  1510 QNHNDGKEDSDIQMGSAVLPHTPGSKAWAVLTSDEESGSGQGTSDSLNDNETSTDFSFPDVNEKD 1574

  Fly  1461 WDSV------------------SVT--HSVSEKQTKASATANGHSSSFAFQSETFTDEKT----- 1500
            .|.|                  |||  ||.....::|.|:.:.|.|.........:::|.
Mouse  1575 TDGVLETDDTGIAPGSPRSSTPSVTSGHSGVSNSSEAEASNSSHESRIGLAEGLESEKKAVIPLV 1639

  Fly  1501 -------------------------TKYFQKE--------------------------VESYEKL 1514
                                     |.:|..|                          ::.:.|.
Mouse  1640 IVSALTFICLVVLVGILIYWRKCFQTAHFYLEDNTSPRVISTPPTPIFPISDDIGAIPIKHFPKH 1704

  Fly  1515 LENLHVKMLNGKTQLGAKWQELQQKLDKEAAANKRSTTIAKLFPE---KNRSLDCLPYDHARVKL 1576
            :.:||..  ||.|:.....:|..|:: :...|:...|..:...|:   |||.::.:.|||:||||
Mouse  1705 VADLHAS--NGFTEEFETLKEFYQEV-QSCTADLGITADSSNHPDNKHKNRYVNIVAYDHSRVKL 1766

  Fly  1577 ------DKQTDDYINAAYMKNLSAGCPN-FIVAQTPQPNTINDFWSMIWSEKSRTVVCL----HT 1630
                  |.:..|||||.|:...:.  |. :|.||.|..:|..|||.|||......:|.:    ..
Mouse  1767 TQLAEKDGKLTDYINANYVDGYNR--PKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEK 1829

  Fly  1631 PNELFDPYWPQALDQPTHYDDYTVTCLKVQQLSHCSEYQLKL--------------SMHGADAVL 1681
            .....|.|||  .|....|..:.|....||.|::.:.....|              |..|..:..
Mouse  1830 GRRKCDQYWP--TDGSEEYGSFLVNQKSVQVLAYYTVRNFTLRNTKLKKLSELFQGSQKGRSSGR 1892

  Fly  1682 DLSLLQLKQWTKGAPAQLLGVAENALETHRQRCKAANAPQ---SPLIMNCLTGSERSELVAIGVC 1743
            .::.....||..      :||.|.:|.......|||.|.:   .|::::|..|..|:     |..
Mouse  1893 LVTQYHYTQWPD------MGVPEYSLPVLAFVRKAAQAKRHAVGPVVVHCSAGVGRT-----GTY 1946

  Fly  1744 AIIATQNKQPILLNTIDVW---SRICAQRQNSLRD------------SAILEQSMQIVLCNAHNV 1793
            .::.:..:|.....|::::   ..|.:||...::.            .|||.:..::...:.|:.
Mouse  1947 IVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVPDSHIHSY 2011

  Fly  1794 LNKRGIMTSYQMKMAPQVTAKEQQENK 1820
            :|         ..:.|..|.|.:.|.:
Mouse  2012 VN---------TLLIPGPTGKTKLEKQ 2029

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mop	NP_648722.2	BRO1_HD-PTP_like	2..363	CDD:185762	53/280 (19%)
		V_HD-PTP_like	368..702	CDD:185747	75/446 (17%)
		ALIX_LYPXL_bnd	421..699	CDD:290660	65/381 (17%)
		Med15	808..>1246	CDD:255446	102/552 (18%)
		Y_phosphatase	1558..1788	CDD:278528	67/275 (24%)
		PTPc	1559..1745	CDD:238006	58/216 (27%)
Ptprz1	XP_006505075.1	alpha_CARP_receptor_like	45..298	CDD:239396	48/275 (17%)
		fn3	313..395	CDD:365830	13/81 (16%)
		PTP_DSP_cys	1714..1997	CDD:391942	70/298 (23%)
		R-PTP-Z-2	2080..2283	CDD:350507
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900