DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mop and Ptpn5

DIOPT Version :9

Sequence 1:	NP_648722.2	Gene:	mop / 39610	FlyBaseID:	FBgn0036448	Length:	1833	Species:	Drosophila melanogaster
Sequence 2:	NP_001157037.1	Gene:	Ptpn5 / 19259	MGIID:	97807	Length:	541	Species:	Mus musculus

Alignment Length:	706	Identity:	145/706 - (20%)
Similarity:	227/706 - (32%)	Gaps:	238/706 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1165 PVPVPTPAP------TSSQAQVPTSPHPSATYTSYSNHPGYSFNPQTGKYEYSSGYQQDTSSLKG 1223
            |.||...||      .|.|.::|..|.||.     .:.|.....|| |...:|...:........
Mouse    11 PQPVEMEAPDEAEGLPSKQKEMPPPPPPSP-----PSEPAQKLPPQ-GAGSHSLTVRSSLCLFAA 69

  Fly  1224 SQ---ASQSYQFSQSGKQQSVGTTDSEIASRSNTATGFDSPIVSHTKVNMAAKDSTSAIEGNESS 1285
            ||   |......|..|......|||  :.|.|.|......|:               |..|   |
Mouse    70 SQFLLACGVLWLSGHGHSWLQNTTD--LISSSLTVLNHLGPV---------------AWLG---S 114

  Fly  1286 NYYSTPYGYLGSVN----------------PQQQPTPAPPSNSTASIYMQSGASSTAETQTTSSG 1334
            ..:..|...|.|:.                |.:.|.|.||.:...|:..|...:.:
Mouse   115 GTWGIPSLLLVSLTVSLVIVTTLVWHLLKAPPEPPAPLPPEDRRQSVSRQPSFTYS--------- 170

  Fly  1335 VPYASSAALTKVEPKPEALPPKVTSNVDLLSDLDIDCSVAVPPPMLPQPVLQPQVVATPTPPASQ 1399
                            |.:..||..:.     ||:|                    |.|..|...
Mouse   171 ----------------EWMEEKVEDDF-----LDLD--------------------AVPETPVFD 194

  Fly  1400 VSVPVKVESVAEHAAPATAEIPVAATEGTAQTPVTIPSGPKCASLDNLSNCSDLSSLENFDWDSV 1464
            ..:.:|.|:     .||:..:.....:....:.|::          .|..|:...:.|.|
Mouse   195 CVMDIKPET-----DPASLTVKSMGLQERRGSNVSL----------TLDMCTPGCNEEGF----- 239

  Fly  1465 SVTHSVSEKQTKASATANGHSSSFAFQSETFTDEKTTKYFQKEVESYEKLL--------ENLHVK 1521
                              |:..|                 .:|..::|.||        |.||.|
Mouse   240 ------------------GYLVS-----------------PREESAHEYLLSASRVLRAEELHEK 269

  Fly  1522 MLNGKTQLGAKWQELQQKLDKEAAANKRSTTIAKLFPEKNRSLDCLPYDHARVKL-----DKQTD 1581
            .|: ...|.|::.|:....     .:.:...|..|. .|||....||..|:||:|     :....
Mouse   270 ALD-PFLLQAEFFEIPMNF-----VDPKEYDIPGLV-RKNRYKTILPNPHSRVRLTSPDPEDPLS 327

  Fly  1582 DYINAAYMKNLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVC---LHTPNELFDPYWPQAL 1643
            .||||.|::..|.....:|..|.|..:|:.|||.|:|.|::..:|.   :...||....|||:
Mouse   328 SYINANYIRGYSGEEKVYIATQGPIVSTVADFWRMVWQERTPIIVMITNIEEMNEKCTEYWPE-- 390

  Fly  1644 DQPTHYDDYTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQ------LKQ-WTKGAPAQ--- 1698
            :|..| |...:|   ||::.|..:|:|:|          :||.:      ||. |....|.|
Mouse   391 EQVVH-DGVEIT---VQKVIHTEDYRLRL----------ISLRRGTEERSLKHYWFTSWPDQKTP 441

  Fly  1699 --------LLGVAENALETHRQRCKAANAPQSPLIMNCLTGSERSE-LVAIGVCAIIATQNKQPI 1754
                    |:...|.|.:.....|       ||:|::|..|..|:. .:|..:|.      :|..
Mouse   442 DRAPPLLHLVREVEEAAQQEGPHC-------SPIIVHCSAGIGRTGCFIATSICC------QQLR 493

  Fly  1755 LLNTIDVWSRICAQRQNSLRDSAILEQSMQIVLCNAHNVLNKRGIMTSYQMKMAPQ 1810
            ....:|:....|..||         ::...|..|..:..::.  .|:.|:.:::.|
Mouse   494 REGVVDILKTTCQLRQ---------DRGGMIQTCEQYQFVHH--AMSLYEKQLSLQ 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mop	NP_648722.2	BRO1_HD-PTP_like	2..363	CDD:185762
		V_HD-PTP_like	368..702	CDD:185747
		ALIX_LYPXL_bnd	421..699	CDD:290660
		Med15	808..>1246	CDD:255446	23/89 (26%)
		Y_phosphatase	1558..1788	CDD:278528	66/256 (26%)
		PTPc	1559..1745	CDD:238006	60/212 (28%)
Ptpn5	NP_001157037.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55		15/49 (31%)
		PTPc-N5	274..531	CDD:350461	73/302 (24%)
		Substrate binding. /evidence=ECO:0000250	472..478		2/5 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900