DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mop and Ptpn20

DIOPT Version :9

Sequence 1:	NP_648722.2	Gene:	mop / 39610	FlyBaseID:	FBgn0036448	Length:	1833	Species:	Drosophila melanogaster
Sequence 2:	XP_006518791.1	Gene:	Ptpn20 / 19256	MGIID:	1196295	Length:	463	Species:	Mus musculus

Alignment Length:	373	Identity:	85/373 - (22%)
Similarity:	150/373 - (40%)	Gaps:	63/373 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly  1452 DLS--SLENFDWDSVSVTHSVSEKQTKASATANGHSSSFAFQSETFTDEKTTKYFQKEVESYEKL 1514
            |:|  ||.| .|:|:.   |.:...:|..:.....||..:..:||...||..    .::.....|
Mouse   121 DVSDRSLRN-RWNSMD---SETAGPSKTVSPVLSGSSRLSKDTETSVSEKEL----TQLAQIRPL 177

  Fly  1515 LENLHVK--------MLNGKTQLG--AKWQELQQKL--DKEAAANKRSTTIAKLFPEKNRSLDCL 1567
            :.|...:        .|..|.:|.  .::.||:|..  |...:.|.....      :|||..|.|
Mouse   178 IFNSSARSAMRDCLNTLQKKEELDIIREFLELEQMTLPDDFNSGNTLQNR------DKNRYRDIL 236

  Fly  1568 PYDHARVKLDKQTDDYINAAYMKNLSAGCPNFIVA-QTPQPNTINDFWSMIWSEKSRTVVCLHTP 1631
            |||..||.|.| ..|||||:|::.::.....|.:| |.|.|.||.|||.|:.......:..:...
Mouse   237 PYDSTRVPLGK-NKDYINASYIRIVNHEEEYFYIATQGPLPETIEDFWQMVLENNCNVIAMITRE 300

  Fly  1632 NEL----FDPYWPQALDQPTHYDDYTVTCLKVQQLSHCSEY------QLKLSMHGADAVLDLSLL 1686
            .|.    ...|||.:|.:|..::.::|    ..:..|.::|      |:.....|....  :..|
Mouse   301 IECGVIKCYSYWPISLKEPLEFEHFSV----FLETFHVTQYFTVRVFQIVKKSTGKSQC--VKHL 359

  Fly  1687 QLKQW-TKGAPAQ---LLGVAENALETHRQRCKAANAPQSPLIMNCLTGSERSELVAIGVCA-II 1746
            |..:| ..|.||.   .:.......::|         ...||:::|..|..|:   .:.:|. ::
Mouse   360 QFTKWPDHGTPASADFFIKYVRYVRKSH---------ITGPLLVHCSAGVGRT---GVFICVDVV 412

  Fly  1747 ATQNKQPILLNTIDVWSRICAQRQNSLRDSAILEQSMQIVLCNAHNVL 1794
            .:..::....:.:::.:::..||...::.....:...:|||....|:|
Mouse   413 FSAIEKNYSFDIMNIVTQMRKQRCGMIQTKEQYQFCYEIVLEVLQNLL 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mop	NP_648722.2	BRO1_HD-PTP_like	2..363	CDD:185762
		V_HD-PTP_like	368..702	CDD:185747
		ALIX_LYPXL_bnd	421..699	CDD:290660
		Med15	808..>1246	CDD:255446
		Y_phosphatase	1558..1788	CDD:278528	57/245 (23%)
		PTPc	1559..1745	CDD:238006	53/201 (26%)
Ptpn20	XP_006518791.1	PTP_DSP_cys	251..457	CDD:391942	45/223 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900