DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mop and Ptpn1

DIOPT Version :9

Sequence 1:	NP_648722.2	Gene:	mop / 39610	FlyBaseID:	FBgn0036448	Length:	1833	Species:	Drosophila melanogaster
Sequence 2:	NP_035331.3	Gene:	Ptpn1 / 19246	MGIID:	97805	Length:	432	Species:	Mus musculus

Alignment Length:	303	Identity:	75/303 - (24%)
Similarity:	129/303 - (42%)	Gaps:	57/303 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly  1505 QKEVESYEKLLENLHVKMLNGKTQLGAKWQELQQKLDKEAAANKRSTTIAKLFPEKNRS--LDCL 1567
            :||.|..:|                ...|..:.|.:..|  |:.....:|||...|||:  .|..
Mouse     4 EKEFEEIDK----------------AGNWAAIYQDIRHE--ASDFPCKVAKLPKNKNRNRYRDVS 50

  Fly  1568 PYDHARVKLDKQTDDYINAAYMKNLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPN 1632
            |:||:|:||.::.:|||||:.:| :.....::|:.|.|.|||...||.|:|.:|||.||.|   |
Mouse    51 PFDHSRIKLHQEDNDYINASLIK-MEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVML---N 111

  Fly  1633 ELFD-------PYWPQALDQPTHYDD--YTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQL 1688
            .:.:       .||||..::...:||  ..:|.:.....|:.:..||:|.........::.....
Mouse   112 RIMEKGSLKCAQYWPQQEEKEMVFDDTGLKLTLISEDVKSYYTVRQLELENLTTKETREILHFHY 176

  Fly  1689 KQW----TKGAPAQLLGVAENALETHRQRCKAANAPQSPLIMNCLTGSERSELVAIG-VCAIIAT 1748
            ..|    ...:||..|.......|:     .:.:....|::::|..|..||....:. .|.::..
Mouse   177 TTWPDFGVPESPASFLNFLFKVRES-----GSLSLEHGPIVVHCSAGIGRSGTFCLADTCLLLMD 236

  Fly  1749 QNKQPILLNTIDVWSRICAQRQ---------NSLRDS--AILE 1780
            :.|.|   :::|:...:...|:         :.||.|  |::|
Mouse   237 KRKDP---SSVDIKKVLLEMRRFRMGLIQTADQLRFSYLAVIE 276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mop	NP_648722.2	BRO1_HD-PTP_like	2..363	CDD:185762
		V_HD-PTP_like	368..702	CDD:185747
		ALIX_LYPXL_bnd	421..699	CDD:290660
		Med15	808..>1246	CDD:255446
		Y_phosphatase	1558..1788	CDD:278528	64/250 (26%)
		PTPc	1559..1745	CDD:238006	55/201 (27%)
Ptpn1	NP_035331.3	PTPc	3..276	CDD:214550	74/301 (25%)
		PTPc	43..276	CDD:238006	61/244 (25%)
		Substrate binding. /evidence=ECO:0000250	215..221		2/5 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..322
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..399
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900