Protein Alignment mop and R155.3

DIOPT Version :10

• Sequence 1: NP_648722.2
• Gene: mop / 39610
• FlyBaseID: FBgn0036448
• Length: 1833
• Species: Drosophila melanogaster
• Sequence 2: NP_497485.1
• Gene: R155.3 / 187909
• WormBaseID: WBGene00020117
• Length: 1165
• Species: Caenorhabditis elegans
• Alignment Length: 1329
• Identity: 213/1329 - (16%)
• Similarity: 425/1329 - (31%)
• Gaps: 446/1329 - (33%)

  Fly     6 RLHMLWFALKSSPEGTSFAALKKYIAEFYHEDPEAYSKEVHALETLRN-QAMHTTKDGAPVMKRY 69
            |||::  .||:|...|...:|.||         ..||::    ||::| :.::::      :::.
 Worm    57 RLHLI--KLKASVTYTQTLSLVKY---------NNYSQK----ETVKNSEVVYSS------LQKV 100

  Fly    70 YCQLHALQNRFPQLADRGIFTFKWKDLYHSAVHEVT----------DLRFERAAVLFNIAALHTQ 124
            |....|| :..|..|..|.......:.:..::..:|          :|...|...:.::|..|..
 Worm   101 YTSSIAL-SELPSKASNGDKIIDMLNSFEKSIKSLTEDSPSIGTLYELLKSRHLRVSSVALKHVS 164

  Fly   125 SGASVTRGDVDGMKMACTHFQ--AAAWAYGELRERYANV-NGGGDFMTPELLVFQQQVCFAQAQE 186
                   |.::|.......|:  ...|....:|:...|: |......|.|....:....|. ::.
 Worm   165 -------GFLNGHSDILHLFKDLEDKWIKDAVRDHSGNLANALNQLKTFEASTRKVHQSFV-SEA 221

  Fly   187 CILEKSLIDNRKPHIVAKVTAQIVVYYGAA--LAALLTGGDDGPVAQVIDSSVYKLWKKYVRFKI 249
            .:||:          |:|:.::|..|.|.|  :|.|     ...:.:::.:...||
 Worm   222 VMLEE----------VSKIRSKIPKYSGLADKIATL-----PSKIHEILGTPSVKL--------- 262

  Fly   250 NYLTCILYLYQGQHSEEKRQMGERVTLYQASWDKLEEARKESKGLPDQREINESLSFTADVVEAK 314
                         .:.:|.::.:.:.| .|......:|.::.....:|.::.|:.....:::|..
 Worm   263 -------------PTSDKDKVDKAIPL-MAQLPAQLKALEKLMNFSEQLKLPENAKKLGNIIEIV 313

  Fly   315 RKNAKNENEFIYHEAVPELSTIAAVQGANLVNGIGFQVSDEEHAGPDIFARLVPMKAHEASSLYS 379
            .::.||:.|          :|:...:.:..|.              :|:..|:|:|
 Worm   314 NQDGKNQLE----------NTLKMFKSSTDVK--------------EIYTLLLPVK--------- 345

  Fly   380 EEKAKLLRKYGALLEEKDTQLESYMSSLTLDNLNINEEQANKLPQGIVDRCAALNA-----NKTA 439
             :..:||         ||..:..     |..|:..:.::..|..|.:.|...|||:     ..:.
 Worm   346 -DTLELL---------KDNPIHE-----TAANIISSLDKVEKFAQDMADFFTALNSIRQIEESSL 395

  Fly   440 ISDLVEAMSQLAEITAD-------------VETNLGEISSMLEAEAKAEREFQSATGVQRTPNAH 491
            |..::..:.|| .::.|             ::|.|..::|.:.:             |::|.:|.
 Worm   396 IIPVITTIRQL-RLSNDQFGLTTVLNNLPMIKTQLSSLTSYINS-------------VKKTKHAE 446

  Fly   492 ITELSREFQKYSEAHARAGESNNTLRKAMSLHVNNLKILARPLPEIQQLMPKLSSELNTTEIFRD 556
             |:..::|:|                  :.||...:....|.:..:|:|:.           |:|
 Worm   447 -TDALKDFEK------------------IGLHSRVIGTATRGISNMQKLVD-----------FKD 481

  Fly   557 V----KLILNKVNEMKAQRAQFHADLRIAINEDDI----------------TGKVIAHGGQEGLQ 601
            :    .|:.::|.::|.|           :|::::                :|:::  |.::.::
 Worm   482 LADIGDLVKSEVEKVKDQ-----------LNDENVANLKALAGIEGQLKTASGEIV--GYKKSVK 533

  Fly   602 ALFATELGKHDKITELLDQNMVAQGNI-LQALTENYAKAAPVLKTLQDVKQKREHFYSSLAASYD 665
            .:.:|.|  .|..|..||...|...|: |.|:..:..|    |..|..::..|....|:....|.
 Worm   534 PVTSTSL--PDYSTFFLDAKKVKGINLKLPAIISSMEK----LNNLVPIRSSRATRSSTQLDGYL 592

  Fly   666 V-YEDLLAKSAKGLEFYKKLAGNVQKL-------------LTRFRSARDVQSEE----------- 705
            : .:.|.:.|....:|:|...|:.|.|             ||:.::|...|...
 Worm   593 LSLQSLSSISLDFTKFHKSFDGSTQSLQDLGVSFAKYNNTLTKQKAAAAAQKSGGGSSSASGGSQ 657

  Fly   706 ----------------------------------------------RQQRMQSVKAATTPVVSKP 724
                                                          |:..|:.||   .||..|.
 Worm   658 GVFESNSTIVLIVFGCIVFICVILIPASSWFYLHQKDPAARKCFAIRELPMEEVK---KPVKKKD 719

  Fly   725 IA----------ETTPVPAVSSTPKL---------RDYLKAK-AAMADASNPAYVPTVRPVPVGS 769
            ::          |.|...::...|||         ..|:..: .|:.|......:|.:      |
 Worm   720 VSKMDNKPERELEKTQDESIKDVPKLILELDMSSAEKYVDCRYEALQDMHKETCIPFL------S 778

  Fly   770 ENPTQAACSYATAPPNEPPPPYSLTQQQY---FDPSAAGYTNP-----MYQQQQQHIAPPAY--- 823
            |                     .|.::.|   ||.....|..|     ..:|.:|.:..|..
 Worm   779 E---------------------ELIKKFYGVKFDAMNEKYEVPGREALKSEQMKQRLPIPLVMDT 822

  Fly   824 --------------------------------KAQASPNSQTLHGALGQMNLQGQSQDNNQAGMA 856
                                            :|....|.::....:.......:.:.:.|..|.
 Worm   823 RVVLKDYGTLFNDDYIHANRVTCSHGLQLILSQAPQEANGESCESTIESYWWTAKQEKSTQLVMM 887

  Fly   857 YNYGYP-SGSVPPLAYAPPGTVPASSASQGLNIQQPLYVATSG---NPVSVSNPSELPSTLQAPF 917
            .::... .|.....|...|.:|..|...:.|.::....:|...   ..:.|......|.|:....
 Worm   888 CDFDEKCPGKTNSCARYYPESVGESMKFKNLTVECKSKIAEKDFETRELEVKFDGHEPHTVTHSR 952

  Fly   918 VV--NPMSNPYQTAAGYSGQAYQQVNAQAQQVTYPTAPSGSSTGQSAQQPLGYAPSQGPQQQAGG 980
            :|  ||::....|....|  ..|::......|........|.:...|...:||
 Worm   953 LVGWNPLNVQPDTLLFTS--LIQKIKNSTTPVMVHCIDGISRSAAFASMIIGY------------ 1003

  Fly   981 YPQSQTPQQQVGAYQQQPLSGY-----AQQLTPQQQTGYSQSQAPQLQAPSYAQNQQSTGQ---- 1036
                |...|.:|:.:.:.:..|     |..:|...:..:..:...:|.. .:...||:.|:
 Worm  1004 ----QLVIQSLGSVKLEAVVSYIRSQRAMAITSALELAFVDAGIVKLLG-LFVDAQQNKGELTRE 1063

  Fly  1037 ----AQQQ-QTGYPQTPQ-QHLAGYAQSQQQATGYPQSQTSQQQTTGYSQSQTPQ-QPLAYQQQP 1094
                |||: ...|...|: |....:.|.||..||..::....:|...|.....|: :|.....:|
 Worm  1064 QCILAQQELMRFYTSCPEAQKWFSWPQKQQAKTGEKRTYKKIKQLKDYGFEVAPEPKPTPIAPEP 1128

  Fly  1095 SGYPQQQQQQSLAPQQ-------PSLYPS 1116
            ...|.:.:.:....|:       |:|.|:
 Worm  1129 KPTPAETKPKDRLEQRGMAKVDGPALEPA 1157

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mop	NP_648722.2	BRO1_HD-PTP_like	2..363	CDD:185762	60/372 (16%)
		V_HD-PTP_like	368..702	CDD:185747	67/386 (17%)
		Glutenin_hmw	<795..1261	CDD:367362	64/394 (16%)
		PHA03247	<1329..1443	CDD:223021
		PRK12323	<1378..1540	CDD:481241
		Y_phosphatase	1558..1788	CDD:459674
R155.3	NP_497485.1	PTPc	802..1045	CDD:214550	34/260 (13%)