DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mop and M05B5.1

DIOPT Version :9

Sequence 1:	NP_648722.2	Gene:	mop / 39610	FlyBaseID:	FBgn0036448	Length:	1833	Species:	Drosophila melanogaster
Sequence 2:	NP_492030.1	Gene:	M05B5.1 / 187450	WormBaseID:	WBGene00010869	Length:	445	Species:	Caenorhabditis elegans

Alignment Length:	460	Identity:	89/460 - (19%)
Similarity:	150/460 - (32%)	Gaps:	139/460 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1473 KQTKASATANGHSSSFAFQSETFTDEKTTKYFQKEVESYEKLLENLHVKMLNGKTQLGAKWQELQ 1537
            ||............:.|...:..|.:.|:|...||.....|..|    |....|.::.|..::.:
Worm     5 KQNVTRRKKKRQDDTIAEDEQEPTQQPTSKEMSKEAMKKGKSKE----KERASKDKMSASGEKAE 65

  Fly  1538 QKLD-----------------KEAAANKR-STTIAKLFP------------EKNRSLDCLPYDHA 1572
            ::.|                 |||:.|.. ...:|...|            .|||:.|....|..
Worm    66 KEKDLKFVAATKGLCKYILDMKEASLNTYFDANLANYSPSKCTFNEWEKNVNKNRTKDVKLIDAT 130

  Fly  1573 RVKLDK-------QTDD---YINAAYMK--NLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTV 1625
            ||.|..       ..||   ||||::::  |.|.   ::|:.|.|.|:||.|||.|::..|...|
Worm   131 RVVLTNPEKSKMGPADDVEGYINASHIRFDNAST---DYILTQYPLPSTIRDFWKMVYVTKVTQV 192

  Fly  1626 VCLHTP----------------------------------------------------NELFDPY 1638
            :.:..|                                                    |.|...:
Worm   193 ITIFEPIKDEAIEEFANFPAPASPVPPPPTASSKDIGSSPDQQPREREQIEIKSIRCDNHLHQSF 257

  Fly  1639 WPQALDQPTHYDDYTVTCLKVQQLSHC----SEYQLKLSMHGADAVLDLSLLQLKQWT-KGAPAQ 1698
            :|.:.|...:.:.:.:....|:....|    ::|.:::...|........:.....|. |..|..
Worm   258 FPLSTDHYLNLEGWLINTRAVEVDQRCKNWMNKYTVEVVADGCSEATFAKVYNCTTWPWKSYPDD 322

  Fly  1699 LLGVAENALETHRQRCKAAN---APQSPLIMNCLTGSERSELVAIGVCAIIATQ---NKQPILLN 1757
            :    :..|...|...|.::   ..|.|:|:.|..|.:||..|.:  .:||..|   .|.|   :
Worm   323 V----KKVLALVRAPVKESSPTVGKQPPVIVMCDLGLDRSATVVL--TSIIIEQVLDGKTP---D 378

  Fly  1758 TIDVWSRICAQRQNSLRDSAILEQSMQIVL--------CNAHNVLNKRG-----IMTSYQMKMAP 1809
            ..|::.::..||......|.....:::..|        |     ||:.|     .|.:..:...|
Worm   379 CDDLFRKMRDQRAGVFTMSIFFTYAIRAALFYLKLKLQC-----LNENGNEDVKTMITEALAKVP 438

  Fly  1810 QVTAK 1814
            .:|.|
Worm   439 FLTKK 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mop	NP_648722.2	BRO1_HD-PTP_like	2..363	CDD:185762
		V_HD-PTP_like	368..702	CDD:185747
		ALIX_LYPXL_bnd	421..699	CDD:290660
		Med15	808..>1246	CDD:255446
		Y_phosphatase	1558..1788	CDD:278528	62/324 (19%)
		PTPc	1559..1745	CDD:238006	51/257 (20%)
M05B5.1	NP_492030.1	RR_TM4-6	<9..>78	CDD:283990	12/72 (17%)
		PTPc	91..409	CDD:214550	63/329 (19%)
		PTPc	118..392	CDD:304379	59/285 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900