DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mop and Pdcd6ip

DIOPT Version :9

Sequence 1:	NP_648722.2	Gene:	mop / 39610	FlyBaseID:	FBgn0036448	Length:	1833	Species:	Drosophila melanogaster
Sequence 2:	XP_011241243.1	Gene:	Pdcd6ip / 18571	MGIID:	1333753	Length:	877	Species:	Mus musculus

Alignment Length:	1050	Identity:	246/1050 - (23%)
Similarity:	421/1050 - (40%)	Gaps:	239/1050 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LWFALKSSPEGTSFAALKKYIAEFY---HEDPEAYSKEVHALETLRNQAMHTTKDGAPVMK---- 67
            :|..||.:.|......|.|:|.:.|   .|:...|.:....|..||..|:     |.|:.|
Mouse     5 IWVQLKKTSEVDLAKPLVKFIQQTYPSGGEEQAQYCRAAEELSKLRRSAL-----GRPLDKHEGA 64

  Fly    68 -----RYYCQLHALQNRFPQLADRGIFTFKWKDLYH-------SAVHEVTDLRFERAAVLFNIAA 120
                 |||.|:.:::.:||...::...||.|||.:.       |....:..|.:|::.||||.||
Mouse    65 LETLLRYYDQICSIEPKFPFSENQICLTFTWKDAFDKGSLFGGSVKLALASLGYEKSCVLFNCAA 129

  Fly   121 LHTQSGASVTRGDVDGMKMACTHFQAAAWAYGELRE-------RYANVNGGGDFMTPELLVFQQQ 178
            |.:|..|.....:.:|:|.|...:|.|:.|:..:::       |...|:     ::|:.:.....
Mouse   130 LASQIAAEQNLDNDEGLKTAAKQYQFASGAFLHIKDTVLSALSREPTVD-----ISPDTVGTLSL 189

  Fly   179 VCFAQAQECILEKSLIDNRKPHIVAKVTAQIVVYYGAALAALLTGGDDGPVAQVIDSSVYK-LWK 242
            :..|||||....|:..|..|..|:||:..|...|:|.|                .....|| ...
Mouse   190 IMLAQAQEVFFLKATRDKMKDAIIAKLANQAADYFGDA----------------FKQCQYKDTLP 238

  Fly   243 KYVRFKINYLT-----CILYLYQGQH----SEEKRQMGERVTLYQASWDKLEEARKESKGLPDQR 298
            ||..|:..:.|     ||:......|    ::::::.||.:.       :|:.|.:..|.:..:.
Mouse   239 KYFYFQEVFPTLAAKQCIMQANAEYHQSILAKQQKKFGEEIA-------RLQHAAELIKNVASRY 296

  Fly   299 EINESLSFTADVVEAKRKNAKNENEFIYHEAVPELSTIAAVQGANLV--NGIGFQVSDEEHAGPD 361
            :...::...:|.:......||.:|:||||:.||:|..:..:..|.||  ..:...||.:   ..|
Mouse   297 DEYVNVKDFSDKINRALTAAKKDNDFIYHDRVPDLKDLDPIGKATLVKPTPVNVPVSQK---FTD 358

  Fly   362 IFARLVPMKAHEASSLYSEEKAKLLRKYGALLEEKDTQLESYMSSLTLDNLNINEEQANKLPQGI 426
            :|.::||:...::.:::|:.||.|:.:..|.:.|..|.....::||.|. ..|.:...:.:||.|
Mouse   359 LFEKMVPVSVQQSLAVFSQRKADLVNRSIAQMREATTLANGVLASLNLP-AAIEDVSGDTVPQSI 422

  Fly   427 VDRCAAL--NANKTAISDLVEAMSQLAEITADVETNLGEISSMLEAEAKAEREFQS--ATGVQRT 487
            :.:..::  ......:..|::.:.:|.:...::   |.|...:|:.|...:.:.::  ....|||
Mouse   423 LTKSTSVVEQGGIQTVDQLIKELPELLQRNREI---LEESLRLLDEEEATDNDLRAKFKDRWQRT 484

  Fly   488 PNAHITE-LSREFQKYSEAHARAGESNNTLRKAMSLHVNNLKILARPLPEIQQLMPKL--SSELN 549
            |:..:.: |..|..|:.....:|.:::..:::....|.:.:.:|.:|.||:...:|..  :..:.
Mouse   485 PSNDLYKPLRAEGAKFRAVLDKAVQADGQVKERYQSHRDTIALLCKPEPELNAAIPSANPAKTMQ 549

  Fly   550 TTEIFRDVKLILNKVNEMKAQRAQFHADLRIAINEDDITGKVIAHGGQEGL---QALFATELGKH 611
            .:|:...:|.:|:.::|:|.:|.....||: ::| .|:|.|.:....|:|:   :||..|||
Mouse   550 GSEVVSVLKSLLSNLDEIKKERESLENDLK-SVN-FDMTSKFLTALAQDGVINEEALSVTEL--- 609

  Fly   612 DKITELLDQNMVAQGNILQALTENYAKAAPVLKTLQ-------DVKQK------REHFYSSLAAS 663
            |:|          .|.:...:.|:..|...:||.:|       .:||.      ||....:||.:
Mouse   610 DRI----------YGGLTSKVQESLKKQEGLLKNIQVSHQEFSKMKQSNNEANLREEVLKNLATA 664

  Fly   664 YDVYEDLLAKSAKGLEFYKKLAGNVQKLLTRFRS-ARDVQSEERQQRMQSVKAATTPVVSKPIAE 727
            ||.:.:|:|...:|.:||.:|.    ::|.||:: ..|:....:.:|.:.:|.....:..:|.|.
Mouse   665 YDNFVELVANLKEGTKFYNELT----EILVRFQNKCSDIVFARKTERDELLKDLQQSIAREPSAP 725

  Fly   728 TTPVPAVSSTPKLRDYLKAKAAMADASNPAYVPTVRPVPVGSENPTQAACSYATAPPNEPPPPYS 792
            :.|.||..|:|          |...|:.|. .|..|.:||.:....|        ||..||||..
Mouse   726 SIPPPAYQSSP----------AAGHAAAPP-TPAPRTMPVSTPAKPQ--------PPARPPPPVL 771

  Fly   793 LTQQQYFDPSAAGYTNPMYQQQQQHIAPPAYKAQASPNSQTLHGALGQMNLQGQSQDNNQAGMAY 857
            ...:                      .|||..|.|.....|...|..|.
Mouse   772 PANR----------------------VPPASAAAAPAGVGTASAAPPQT---------------- 798

  Fly   858 NYGYPSGSVPPLAYAPPGTVPASSASQGLNIQQPLYVATSGNPVSVSNPSELPSTLQAPFVVNPM 922
                |..:.||.|..||               .|.|..             .|...|.|.   ||
Mouse   799 ----PGSAPPPQAQGPP---------------YPTYPG-------------YPGYCQMPM---PM 828

  Fly   923 SNPYQTAAGYSGQAYQQVNAQAQQVTYPTAPSGSSTGQSAQQPLGYAPSQGPQQQAGGYPQSQTP 987
                    ||:..||.|.|     :.||..         ..|..|.||..||||..  ||..|.|
Mouse   829 --------GYNPYAYGQYN-----MPYPPV---------YHQSPGQAPYPGPQQPT--YPFPQPP 869

  Fly   988 QQQVGAYQQQ 997
            ||..  |.||
Mouse   870 QQSY--YPQQ 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mop	NP_648722.2	BRO1_HD-PTP_like	2..363	CDD:185762	95/390 (24%)
		V_HD-PTP_like	368..702	CDD:185747	80/357 (22%)
		ALIX_LYPXL_bnd	421..699	CDD:290660	67/301 (22%)
		Med15	808..>1246	CDD:255446	45/189 (24%)
		Y_phosphatase	1558..1788	CDD:278528
		PTPc	1559..1745	CDD:238006
Pdcd6ip	XP_011241243.1	BRO1_Alix	2..350	CDD:185763	92/377 (24%)
		V_Alix	365..703	CDD:185748	80/360 (22%)
		Amelogenin	<823..>877	CDD:197891	27/82 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2220
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.704428	Normalized mean entropy	S2147
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D498845at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R147
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.800