DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mop and ptpn-22

DIOPT Version :9

Sequence 1:	NP_648722.2	Gene:	mop / 39610	FlyBaseID:	FBgn0036448	Length:	1833	Species:	Drosophila melanogaster
Sequence 2:	NP_500128.2	Gene:	ptpn-22 / 176981	WormBaseID:	WBGene00021507	Length:	469	Species:	Caenorhabditis elegans

Alignment Length:	458	Identity:	110/458 - (24%)
Similarity:	181/458 - (39%)	Gaps:	108/458 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1383 PVLQPQVVATPTPPASQVSVPVKVESVAEHAAPATAEIPVAATEGTAQTPVTIPSGPKCASLDNL 1447
            |.:|.|...:|.||....:..||                        .||..:|:|
Worm    16 PEIQEQKPKSPPPPLPTSNPVVK------------------------DTPNVVPTG--------- 47

  Fly  1448 SNCSDLSSLENFDWDSVSVTHSVSEKQTKASATANGHSSSFAFQSETFTDEKT------TKYFQK 1506
                ||...|             ||::..|:...||:...|         ||.      .:.|.|
Worm    48 ----DLIQFE-------------SEEERAATTVPNGNPVIF---------EKNPAMDGLLREFLK 86

  Fly  1507 EVESY--EKLLENLHVKMLNGKTQLGAKWQELQQKLDKEAAANKRSTTIAKLFPEKNRSLDCLPY 1569
            |.|:|  :..|...:        |:..:    |:||..| |..:....:|.....:||..|.|||
Worm    87 EEEAYTPQDYLRRFY--------QIRVE----QEKLRME-AEYRSECAVAPQHYARNRYRDILPY 138

  Fly  1570 DHARVKLDKQTDD---YINAAYMKNLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTP 1631
            |..||::.|.:::   |:||:.:: |..|...||.||.|.|.|::::|.||...:...||.|...
Worm   139 DKNRVEIQKDSENPEGYMNASLIQ-LPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKL 202

  Fly  1632 NEL----FDPYWPQALDQPTHYDDYTVTCLKVQQLSHCSEYQ---LKLSMHGADAVLDLSLLQLK 1689
            .||    .:.|||:.:.:...:.||.:| |:.::|....||.   ||:..........:..|..:
Worm   203 VELNKIKCERYWPEQVGESELFGDYEIT-LEEEKLFDDDEYLMRCLKMENQTTGECRKVHQLHYR 266

  Fly  1690 QW-TKGAPA---QLLGVAENALETHRQRCKAANAPQ--SPLIMNCLTGSERS-ELVAIGVCAIIA 1747
            :| ..|.|:   |||.:.:.....|.:     .:||  ||::::|..|..|: .::||.   .|.
Worm   267 EWPDHGCPSGEKQLLNMIDLMENIHEE-----VSPQDSSPILVHCSAGVGRTGTIIAIN---FIR 323

  Fly  1748 TQNKQPILLNTIDVWSRICAQRQNSLRDSAILEQSMQIVLCNAHNVLNKRGIMTSYQMKMAPQVT 1812
            .|.|.. .|::||::..:...|:.........:|...:..|.|.......||:...::.:||.|.
Worm   324 EQMKAE-TLHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYCRRHLGIIEEPKLDLAPPVA 387

  Fly  1813 AKE 1815
            ..:
Worm   388 TAD 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mop	NP_648722.2	BRO1_HD-PTP_like	2..363	CDD:185762
		V_HD-PTP_like	368..702	CDD:185747
		ALIX_LYPXL_bnd	421..699	CDD:290660
		Med15	808..>1246	CDD:255446
		Y_phosphatase	1558..1788	CDD:278528	67/246 (27%)
		PTPc	1559..1745	CDD:238006	59/202 (29%)
ptpn-22	NP_500128.2	PTPc	102..365	CDD:214550	75/278 (27%)
ptpn-22	NP_500128.2	PTPc	129..365	CDD:238006	68/246 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810