DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mop and alx-1

DIOPT Version :9

Sequence 1:	NP_648722.2	Gene:	mop / 39610	FlyBaseID:	FBgn0036448	Length:	1833	Species:	Drosophila melanogaster
Sequence 2:	NP_001022713.1	Gene:	alx-1 / 176410	WormBaseID:	WBGene00007010	Length:	882	Species:	Caenorhabditis elegans

Alignment Length:	1044	Identity:	251/1044 - (24%)
Similarity:	389/1044 - (37%)	Gaps:	235/1044 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LKSSPEGTSFAALKKYIAEFYHEDPEAYS---KEVHALETLRNQA----MHTTKDGAPVMKRYYC 71
            |||:.|......|..||...|:......|   :.|..|..||::|    :...:....|:.|||.
Worm    11 LKSTNEVDLVKPLTSYIDNVYNTSDNNRSDVAEAVQELNKLRSKACCQPLDKHQSALDVLTRYYD 75

  Fly    72 QLHALQNRFPQLADRGIFTFKWKDLYHS-------AVHEVTDLRFERAAVLFNIAALHTQSGASV 129
            ||.|::|:....|.:....|||||.:..       |...::|..||||||||||.:|.:|.||:.
Worm    76 QLVAIENKIIISATQNPVVFKWKDAFDKGSLFSSRASLSLSDGSFERAAVLFNIGSLMSQIGAAQ 140

  Fly   130 TRGDVDGMKMACTHFQAAAWAYGELRERYANV---NGGGDFMTPELLVFQQQVCFAQAQECILEK 191
            .....|.:|::...||.:|..:..||:....:   ....|.| |:.|.....:..|||||.|..|
Worm   141 QFHTDDEIKVSAKLFQQSAGVFARLRDVVLGMVQQEPTPDLM-PDTLAALSALMTAQAQEAIYIK 204

  Fly   192 SLIDNRKPHIVAKVTAQIVVYYGAALAALLTGGDDGPVAQVIDSSVYKLWKKYVRFKINYLTCIL 256
            ...|..|...:.|::||:..:|..|...:        ...::.....|.|...|..|......:.
Worm   205 GHKDKMKATSMVKISAQVAEFYSEAQKMM--------SKDIVRGLWDKDWSAIVSGKNLAYQALA 261

  Fly   257 YLYQGQHSEEKRQMGERVTLYQASWDKLEEARKESKGLPDQREINESLSFTADVVEAKRKNAKNE 321
            ..:|.:...|.||:||:::....|....:.|:|.   ||  |:|.........|.:| ...||.:
Worm   262 QYHQSEVCGEARQIGEQLSRLAESLKLFDTAQKY---LP--RDITGIWDIYPSVSKA-HAAAKKD 320

  Fly   322 NEFIYHEAVPELSTIAAVQGANLVNGIGFQVSDEEHAGP------DIFARLVPMKAHEASSLYSE 380
            |:|||||.|.:..|:..:..|.|......|.       |      |:||.|||::.|.|...|..
Worm   321 NDFIYHEKVSDFRTLPTLPKAVLAKPTPMQT-------PMTPSFRDMFAVLVPVQVHNAMQSYDA 378

  Fly   381 EKAKLLRKYGALLEEKDTQLESYMSSLTLDNLNINEEQANKLPQGIVDRCAALNANKTAISDLVE 445
            .||:|:......:.|....:...::||.|.....:......||:.:..:.|.|..|..: |:::.
Worm   379 RKAELVNMETVRMREATQLMNGVLASLNLPAALDDVTSTETLPESLKLKSAKLKQNGGS-SEIMR 442

  Fly   446 AMSQLAEITADVETNLGEISSMLEAEAKAEREFQSATGVQ--RTPNAHIT-ELSREFQKYSEAHA 507
            ..|:|..:....|..|.|.|.:|..|.:::...:...|.:  |..:..:| .|..|..||.....
Worm   443 LFSELPTLYQRNEDILTETSRILNEEKESDDTMRKQLGTKWTRMSSEQLTGPLVTEIGKYRGILH 507

  Fly   508 RAGESNNTLRKAMSLHVNNLKILARPLPEIQQLMP-KLSSELNTTEIFRDVKLILNKVNEMKAQR 571
            .|..::..:::....|...:::|::...|::..:| :.:.....|:..|.::..:::.||:...|
Worm   508 TASNADKMVKEKFESHRQGIELLSKNESELRSSIPGQTAHATGETDTVRQLRQFMSQWNEVTTDR 572

  Fly   572 AQFHADLR-----IA------------INEDDITGKVIAHGGQEGLQALFATELGKHDKITELLD 619
            .....:|:     ||            |||:.|:.:.||.        :|. :|.:  ::...||
Worm   573 ELLEKELKNTNCDIANDFLKAMAENQLINEEHISKEKIAQ--------IFG-DLKR--RVQSSLD 626

  Fly   620 QNMVAQGNILQALTENYAKAAPVLKTLQDVKQKREHFYSSLAASYDVYEDLLAKSAKGLEFYKKL 684
            ...... |.:||....:...    ||......:||.....||.:.|.|.:|.|...:|.:||..|
Worm   627 TQETLM-NQIQAANNTFTGE----KTGSSTGAERERILKMLAQASDAYVELKANLEEGTKFYNDL 686

  Fly   685 AG---NVQKLLTRFRSARDVQSEERQQRMQSVKAATTPVVSKPIAETTPVPAVSSTPKLRDYLK- 745
            ..   .:|:.::.|..||..:.|:..:::|      ..:||...|:.. |..|:|.  :..||.
Worm   687 TPILVRLQQKVSDFAFARQTEKEDLMRQLQ------LSIVSGQAAKAV-VDGVNSL--VSSYLTG 742

  Fly   746 -AKAAMADASNPAYVPTVRPVPVGSENP-----TQAACSYATAPPNEPPP--PYSLTQQQYFDPS 802
             ..||.:.|:.|...|..||.....|:|     ||.:..   |.|..||.  ||...||
Worm   743 GTNAAQSPANAPPRPPPPRPAAPSVESPIPPPRTQQSMQ---ATPGAPPQYNPYQQQQQ------ 798

  Fly   803 AAGYTNPMYQQQQQHIAPPAYKAQASPNSQTLHGALGQMNLQGQSQDNNQAGMAYNYGYPSGSVP 867
                  |..||.|||   |.|..|..|                             ||.|
Worm   799 ------PQMQQFQQH---PGYYQQPMP-----------------------------YGQP----- 820

  Fly   868 PLAYAPPGTVPASSASQGLNIQQPLYVATSGNPVSVSNPSELPSTLQAPFVVNPMSNPYQTAAGY 932
                                  ||::           .|...| |..||
Worm   821 ----------------------QPMF-----------QPQYQP-TFAAP---------------- 835

  Fly   933 SGQAYQQVNAQAQQVTYPTAPSGSSTGQSAQQPLGYAPSQGPQQQAGGYPQSQTPQQQVGAYQQQ 997
                            |||.| |:......|.|        .|||.||:|    |..|.|...||
Worm   836 ----------------YPTFP-GAFPSYQQQWP--------QQQQQGGFP----PNPQFGQQNQQ 871

  Fly   998 PLSG 1001
            ...|
Worm   872 QGGG 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mop	NP_648722.2	BRO1_HD-PTP_like	2..363	CDD:185762	103/371 (28%)
		V_HD-PTP_like	368..702	CDD:185747	76/357 (21%)
		ALIX_LYPXL_bnd	421..699	CDD:290660	63/301 (21%)
		Med15	808..>1246	CDD:255446	39/194 (20%)
		Y_phosphatase	1558..1788	CDD:278528
		PTPc	1559..1745	CDD:238006
alx-1	NP_001022713.1	BRO1_Alix	4..351	CDD:185763	100/354 (28%)
		V_Alix	366..704	CDD:185748	74/354 (21%)
		ALIX_LYPXL_bnd	419..707	CDD:290660	65/304 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.704428	Normalized mean entropy	S2147
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D498845at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R147
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.900