DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mop and F20H11.4

DIOPT Version :9

Sequence 1:	NP_648722.2	Gene:	mop / 39610	FlyBaseID:	FBgn0036448	Length:	1833	Species:	Drosophila melanogaster
Sequence 2:	NP_498458.1	Gene:	F20H11.4 / 175937	WormBaseID:	WBGene00017647	Length:	446	Species:	Caenorhabditis elegans

Alignment Length:	473	Identity:	107/473 - (22%)
Similarity:	172/473 - (36%)	Gaps:	157/473 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1468 HSVSEKQTKASATANGHSSSFAFQSE-----TFTDEKTTK----------YFQKEVESYEKLLEN 1517
            ::|.||:.......||.....:...|     .|.|.|..|          ..:|||:..||..:.
Worm    16 NNVVEKKVDKKGKKNGSKEEKSRNPEKEEKSKFKDLKEEKSKVPDDGKKQEDKKEVKKEEKKKDE 80

  Fly  1518 LHVKMLNGKTQLGAKWQELQQKLDKEAAANKR--------------------------STTIA-- 1554
            .:.|..|.|:       :::...|.:..|||:                          ||.:|
Worm    81 KNKKSKNRKS-------KMKPPPDTQELANKKKFCNWFFVDELDCKKLMRDFVALRAPSTCVADT 138

  Fly  1555 -KLFPEKNRSLDCLPYDHARVKLDKQ--TDDYINAAYMKNLSAGCPN---FIVAQTPQPNTINDF 1613
             |...||.|..|.|..|..||.|..:  .:|:|:|.:|.     .|:   :|.||.|...|:.||
Worm   139 MKKHSEKCRYYDILCPDATRVVLQNRPPDNDFIHANWMT-----MPDKFRYISAQGPMDQTVEDF 198

  Fly  1614 WSMIWSEKSRTVVCLHTPNELFDPYWPQALDQPTHYDDYTVTCLKV----QQLSH-CSEYQL--- 1670
            |.|:::||:..||.:..        |.         :|....|.:.    ..:|| |..|::
Worm   199 WHMVYTEKAPAVVMICD--------WE---------EDGIQKCSRYIPSEDNISHVCGIYRITKI 246

  Fly  1671 -KLSMHGAD--------AVLDLSL----LQLK-----QW-TKGAPAQLLGVAENALETHRQRCKA 1716
             :::|..||        :|.|.||    |.:|     :| ...||...:.|.        :..||
Worm   247 DQMTMVYADVALQSFEISVTDKSLECPSLVVKHYHFLKWRDHTAPMTSISVL--------KLLKA 303

  Fly  1717 ANAPQ--SPLIMNCLTGSERSELVAIGVCAIIATQNKQPI----LLNTIDVWSRICAQRQNSLRD 1775
            ...|:  .|.:::|..|..|:..: |||     ....|.|    .:|.:|:     .:....:||
Worm   304 LRDPKRPGPPVIHCSAGIGRTATL-IGV-----DYGNQRIGEVGEMNVLDI-----VREMRQMRD 357

  Fly  1776 SAIL--EQSMQIVLCNA-----------HNVLNKRGIMTSYQMKMAPQ-------VTAKEQQENK 1820
            .|:.  .|.:.:::|.|           .|:|:.....|.:..|:..:       ..||:::|.|
Worm   358 KAVQSHHQFIFMLMCIADRMVLDGVPQNDNMLDLADFYTEFMKKVLMERKKKDEAEKAKKEKEEK 422

  Fly  1821 -------DPLNELDALWK 1831
                   |..||..||.|
Worm   423 RKRDEANDKTNEKSALSK 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mop	NP_648722.2	BRO1_HD-PTP_like	2..363	CDD:185762
		V_HD-PTP_like	368..702	CDD:185747
		ALIX_LYPXL_bnd	421..699	CDD:290660
		Med15	808..>1246	CDD:255446
		Y_phosphatase	1558..1788	CDD:278528	65/269 (24%)
		PTPc	1559..1745	CDD:238006	57/219 (26%)
F20H11.4	NP_498458.1	Y_phosphatase	142..375	CDD:278528	66/273 (24%)
F20H11.4	NP_498458.1	PTPc	144..375	CDD:238006	66/271 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900