DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mop and F25H5.7

DIOPT Version :9

Sequence 1:	NP_648722.2	Gene:	mop / 39610	FlyBaseID:	FBgn0036448	Length:	1833	Species:	Drosophila melanogaster
Sequence 2:	NP_492454.1	Gene:	F25H5.7 / 172740	WormBaseID:	WBGene00009129	Length:	490	Species:	Caenorhabditis elegans

Alignment Length:	505	Identity:	108/505 - (21%)
Similarity:	182/505 - (36%)	Gaps:	162/505 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1447 LSNCSDLSSLENFD---------WDSVSVTHSVSEKQTKASATANGHS------SSFAFQSETFT 1496
            :|:|:..:.|.|..         |...|   ..::|:|| :.|...|.      .....:..:.:
Worm     1 MSDCNWTNPLCNTSLLLASGYALWSCAS---KKNKKETK-TETKKSHDCPPQTIEPVKDEKNSNS 61

  Fly  1497 DEKTTKYFQKEVESYEKLLENLHVK---------MLN-----------------------GKTQL 1529
            :||.|.....||...:||:.|..||         :|:                       .|.:|
Worm    62 EEKKTTSSNNEVPPQKKLIGNDEVKKEKKKSEDDLLDVKKTASKEDDKKRMDKKDPSKKLSKEKL 126

  Fly  1530 GAKWQELQQKLDKEAAANK-----------------------------RSTTIAKLF-------- 1557
            ..:.:|..:|::||...||                             :...|:||.
Worm   127 REEKKEQSKKVNKEKKMNKSESVDEDNEQPPEPGSDPRKIWAFKAAKMKCQAISKLHQDKIKGYM 191

  Fly  1558 ------------PEKNRSLDCLPYDHARVKLDKQTDDYINAAYMKNLSAGCPNFIVAQTPQPNTI 1610
                        |:.||..|....:..||.|.....|||:|::|:........:|..|.|.|.|:
Worm   192 PPNCTYTAYDANPDLNRYADVRCIEETRVVLKNHDRDYIHASWMRMPGKDQSTYITTQGPLPETL 256

  Fly  1611 NDFWSMIWSEKSRTVVCLHTPNELFDP-------YWPQALDQPTHYDDYTVTCLKVQQLSHCSEY 1668
            :|||.||:.||...|:.|.|   ||:.       |:|:.|.:...:..|.:|      |:.|.|.
Worm   257 SDFWHMIYQEKIAYVLMLCT---LFEGGVEKCALYYPEKLGEVVKFGKYEIT------LTECKEE 312

  Fly  1669 QLKLSMHGADAV----------LDLSLLQLKQWTKGAPAQLLGVAENA---LETHRQRCKAANAP 1720
            .:..::..|..|          |.::.:|:..|    |.||  ..|:|   :|.::. .|..|..
Worm   313 AIAGTIWNALTVTNTEDASSEPLYMNHVQVPWW----PDQL--APEDARPMIELYKW-VKKVNPK 370

  Fly  1721 QSPLIMNCLTGSER-SELVAIGVCAIIATQNKQPILLNTIDVWSRICAQRQNSLRDSAILEQSMQ 1784
            ::|:.::|..|..| :..|.|....|...:|....:|:.:        :...::|..|: :..||
Worm   371 ETPICVHCSAGVGRTATFVGIDYATIRIMENPNIEMLDIV--------REMRAMRFQAV-QSHMQ 426

  Fly  1785 -----IVLCN---AHNVLNKRG----IMTSY----QMKMAPQVTAKEQQE 1818
                 :||..   ...|:.:.|    .||.|    |.|:|.:....:|.|
Worm   427 FLFLYVVLMEYFIGEGVVERTGRVDTFMTQYKKHAQKKLAKRAAQNQQGE 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mop	NP_648722.2	BRO1_HD-PTP_like	2..363	CDD:185762
		V_HD-PTP_like	368..702	CDD:185747
		ALIX_LYPXL_bnd	421..699	CDD:290660
		Med15	808..>1246	CDD:255446
		Y_phosphatase	1558..1788	CDD:278528	64/255 (25%)
		PTPc	1559..1745	CDD:238006	55/206 (27%)
F25H5.7	NP_492454.1	PTPc	192..436	CDD:214550	65/268 (24%)
F25H5.7	NP_492454.1	PTPc	205..436	CDD:238006	64/255 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900