DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mop and egg-5

DIOPT Version :9

Sequence 1:	NP_648722.2	Gene:	mop / 39610	FlyBaseID:	FBgn0036448	Length:	1833	Species:	Drosophila melanogaster
Sequence 2:	NP_491316.1	Gene:	egg-5 / 172007	WormBaseID:	WBGene00020035	Length:	753	Species:	Caenorhabditis elegans

Alignment Length:	674	Identity:	119/674 - (17%)
Similarity:	210/674 - (31%)	Gaps:	210/674 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1205 TGKYEYSSGYQQDTSSLKGSQASQSYQFSQSGKQQSVGTTDSEIASRSNTATGFDSPIVSHTKVN 1269
            |....:.||...|:|:...........:.|   |:.|....:...|.|..:..|...:     ..
Worm    26 TSLQSFCSGNTDDSSADSTDNMDMMVDYPQ---QKGVSCMRARFNSESTLSKSFRKKV-----KK 82

  Fly  1270 MAAKD--STSAIEGNESSNYYSTPYGYLGSVNPQQQPTPAPPSNSTASIYMQSGASSTAETQTTS 1332
            :|.||  |...:.||...:....|.|             ||.:.:..|...:|.|..
Worm    83 LAQKDRRSKERLNGNSEEDAIEVPRG-------------APSTYAAPSKLRKSKALD-------- 126

  Fly  1333 SGVPYASSAALTKVEPKPEALPPKVTSNVDL------LSDLDIDCSVAVPPPMLPQPVLQPQVVA 1391
                     .|...:||.|..........|:      .:|:.:.. .|....|..:|.|   |:.
Worm   127 ---------CLVSEKPKDEGRSEDSGHGADIEMAKGHFNDVRMKV-FAARTAMQVEPAL---VMK 178

  Fly  1392 TPTPPASQVSVPVKVESVAEHAAPAT----AEIPVAATEGTAQTPVTIPSGPKC----------A 1442
            |      :.::.:|...:..|.:|..    |...:||:..:....:| |...|.          :
Worm   179 T------RKALEMKNAVLENHQSPGAFSLHAAYKIAASAESRVGSIT-PCNKKVTKEAMANLIRS 236

  Fly  1443 SLDNLSNCSDLSSLENFD--WDS--VSVTHSVSEKQTKASATANGHS---------SSFAFQSET 1494
            |.|:.....:|.....||  |..  ..:.....|...|.....||..         ..|...|..
Worm   237 SYDDTEITQELLFSSKFDSKWKGRYTDIYMRRDENGKKPKRPVNGQGWVMPLKSICEKFGINSTF 301

  Fly  1495 FT-------------------------------------DEKTTKYFQKEVE--SYEKLLENLHV 1520
            ||                                     :|...:|..:|::  :.:|.::....
Worm   302 FTNHRIDLKSARDQVLLMRLLSHDQTSTWISDIHPEAVKNETLAEYLLRELDASTMQKRVQAFKA 366

  Fly  1521 KMLNGKTQLGAKWQ-----ELQQKLDKEAAANKRSTTI----AKLFPEKNRSLDCLPYDHA---- 1572
            .:|..:.::....|     .:.:::...|...|..:||    .:.|.....|::.:|:.|:
Worm   367 NVLADRDRVRVAGQFYNNIRIGKRMFGAARKAKYLSTIIGGMERRFEILENSVNHIPFTHSASDN 431

  Fly  1573 ----------------RVKLDKQTDDYINAAYMKNLSAGCP---NFIVAQTPQPNTINDFWSMIW 1618
                            |:.|......|:......|..:|.|   .||:.|.|..||::|||.|:|
Worm   432 NQEKCRNPRVHCRDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVW 496

  Fly  1619 SEKSRTVVCLHTPN--ELFDPYWPQALDQPTHYDDYTVTCLKVQQLSHCSEYQLKLSMHGADAVL 1681
            .|:...:|.|.:..  |..:.|||::...|      .||.....::.:...||      ..|.:.
Worm   497 QEEVPYIVMLTSRKEPERCEYYWPKSPSDP------AVTVPGGLRIENFGVYQ------APDPLF 549

  Fly  1682 DLSLLQL----------KQWTKG---------APAQLLGVAENA-----LETHRQRCKAANAPQS 1722
            .::.|:|          :.| :|         :|..:|.:..||     :..|....:||
Worm   550 RVTHLRLIGPDREERHVEHW-QGDVNNSSNMYSPLNILRLLRNASKPVVIHDHLGVSRAA----- 608

  Fly  1723 PLIMNCLTGSERSELVAIGVCAII 1746
                 ||..:|      |.:|:::
Worm   609 -----CLVAAE------IAICSLL 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mop	NP_648722.2	BRO1_HD-PTP_like	2..363	CDD:185762
		V_HD-PTP_like	368..702	CDD:185747
		ALIX_LYPXL_bnd	421..699	CDD:290660
		Med15	808..>1246	CDD:255446	8/40 (20%)
		Y_phosphatase	1558..1788	CDD:278528	49/238 (21%)
		PTPc	1559..1745	CDD:238006	49/234 (21%)
egg-5	NP_491316.1	PTPc	407..660	CDD:214550	50/244 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900