DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mop and Ptprg

DIOPT Version :9

Sequence 1:	NP_648722.2	Gene:	mop / 39610	FlyBaseID:	FBgn0036448	Length:	1833	Species:	Drosophila melanogaster
Sequence 2:	NP_599183.2	Gene:	Ptprg / 171357	RGDID:	620774	Length:	1442	Species:	Rattus norvegicus

Alignment Length:	1488	Identity:	292/1488 - (19%)
Similarity:	502/1488 - (33%)	Gaps:	416/1488 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   568 KAQRAQFH--ADLRIAINEDDITGKVIAHGGQEGLQALFATELGKHDKITELLDQNMV--AQGNI 628
            ||::.:||  .....|.:|..:.|:......|     :|.......|.....:.:|.:  |....
  Rat   144 KAEKVEFHWGHSNGSAGSEHSVNGRRFPVEMQ-----IFFYNPDDFDSFQTAISENRIIGAMAIF 203

  Fly   629 LQALTENYAKAAPVLKTLQD-VKQKREHFYSSLAASYDVYEDLLAKSAKGLEFYKKLAGN----- 687
            .|....:.:...|::..|:. |..::|.|....     |..|||..|   |..|.:..|:
  Rat   204 FQVSPRDNSALDPIIHGLKGVVHHEKETFLDPF-----VLRDLLPAS---LGSYYRYTGSLTTPP 260

  Fly   688 ----VQKLLTR---------FRSARDVQSEERQQRMQSV----------KAATTPVVSKPIAETT 729
                |:.::.|         ..:...:.:.|:|..::||          :|....||||.....
  Rat   261 CSEIVEWIVFRRPVPISYHQLEAFYSIFTTEQQDHVKSVEYLRNNFRPQQALNDRVVSKSAVRD- 324

  Fly   730 PVPAVSSTPKLRDYLK----AKAAMADASNPAYVPTVRPVPVGSENPTQAACSYATAPPNEPPP- 789
                 :....|.|:|.    .:|:...:|.|.:: .|:|:     |.|....|::.......||
  Rat   325 -----AWNHDLADFLDNPLGTEASKVCSSPPIHM-KVQPL-----NQTALQVSWSQPETIYHPPI 378

  Fly   790 -----PYSLTQQQYFDPSAAGYTNPMYQQQQ---QHIAPPA---YKAQA-------SPNSQTLHG 836
                 .||.|:.:  |.....:|....:..:   .||:|.:   ::.||       |..|||
  Rat   379 MNYMISYSWTKNE--DEKEKTFTKDSDKDLKATISHISPDSLYLFRVQAVCRNDMRSDFSQT--- 438

  Fly   837 ALGQMNLQGQSQDNNQAGMAYNYGYPSGSVPPLAYAPPGTVPASSA---SQGL-----NIQQPLY 893
                |..|..:....|.......|.|:.|  |.:.|....:.:.|:   |.|:     ::...:.
  Rat   439 ----MLFQANTTRIFQGTRIVKTGVPTAS--PASSADMAPISSGSSTWTSSGIPFSFVSMATGMG 497

  Fly   894 VATSGNPVSVSNPSELPSTLQA------------PFVVNPMSNPYQTAAGYSGQAYQQVNAQAQQ 946
            .::||:..:|:  |.:.|||.|            |..|.|...|  ||:..|.||.:.|.|..:.
  Rat   498 PSSSGSQATVA--SVVTSTLLAGLGFGGGGISSFPSTVWPTRLP--TASAASKQAGRPVLATTEA 558

  Fly   947 VTYPTAPSGSSTGQSAQQPLGYAPSQGPQQQAGGYPQSQTPQQQVGAYQQQPLSGYAQQLTPQQQ 1011
            :..|     ...|.||....|....:|.:::.......:..|      :::......::.:....
  Rat   559 LASP-----GPDGDSAPTKDGEGAEEGEKEEKSESEDGEREQ------EEEEKDSEKKEKSEATH 612

  Fly  1012 TGYSQSQAPQLQAPSYAQNQQSTGQAQQQQTGYPQTPQQHLAGYAQSQQQATGYPQSQTSQQQTT 1076
            |.....|......||   :...|.|....|| .|...|.|.|       ..|..|........|.
  Rat   613 TAAESDQTAPAPTPS---SPHRTAQEGGHQT-IPGHRQDHSA-------PVTDQPGHVDPGLDTL 666

  Fly  1077 GYSQSQTPQQPLAYQQQPSGYPQQQQQQSLAPQQPSLYP----------SQAVQASP-------- 1123
            ..:.:|.|  |.|.::..||...::      |:.||..|          |:.:..:|
  Rat   667 VDTATQVP--PTATEEHYSGSDPKR------PEMPSKKPISRGDRFSEDSKFITVNPAEKNTSGM 723

  Fly  1124 --QPIPGQQ--ATP---------------------------------PNAGQPLPYPQQ------ 1145
              :|.||:.  ..|                                 |...:.:|...:
  Rat   724 ISRPSPGRMEWIIPLIVVSALTFVCLVLLIAVLVYWRGCNKIKSKGFPRRSREVPSSGERGEKGS 788

  Fly  1146 ---------YTDPNAAPAPAPGVSSVPSPVPVPTPAPTSSQAQVPTSPHPSATYTSYSNHPG--Y 1199
                     |.:.:::|...|..|     :|: .|.|...:| :|..        .:..|.|  |
  Rat   789 RKCFQTAHFYVEDSSSPRVVPNES-----IPI-IPIPDDMEA-IPVK--------QFGKHIGELY 838

  Fly  1200 SFNPQTGKYEYSSGYQQDTSSLKGSQASQSYQFSQSGKQQSVGTTDSEIASRSNTATGFDSPIVS 1264
            | |.|       .|:..|...::...|..:.....|..      .|::..:|......:|
  Rat   839 S-NSQ-------HGFSGDFEEVQRCTADMNITAEHSNH------PDNKHKNRYINILAYD----- 884

  Fly  1265 HTKVN---MAAKDSTSAIEGNESSNY---YSTPYGYLGSVNP----------------------- 1300
            |::|.   :..|||..:...|  :||   |:....|:.:..|
  Rat   885 HSRVKLRPLPGKDSKHSDYIN--ANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIIMI 947

  Fly  1301 ------------QQQPTPAPPSNSTASIYMQSGASSTAETQTTSSGVPYASSAALTKVEPKPEAL 1353
                        |..||..........:.::|       |:..:.......|...|||: |.:..
  Rat   948 TNLVEKGRRKCDQYWPTENTEEYGNIIVTLKS-------TEVHACYTVRRFSVRNTKVK-KGQKG 1004

  Fly  1354 PPKVTSNVDLLSDLDIDCSVAVPPPMLPQPVLQPQVVATPTPPASQVSVPVKVESVAEHAA--PA 1416
            .||...|                    .:.|:|......|.....:.::||........||  |.
  Rat  1005 NPKGRQN--------------------ERTVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPD 1049

  Fly  1417 TAEIPVAATEGTAQTPVTIPSGPKCASLDNLSNCSDLSSLENFDWDSVSVTHSVSEKQTKASATA 1481
            ...:.|..:.|..:|...|       .:|::     |..::  |..:|:|...:...:|:.:...
  Rat  1050 MGPVLVHCSAGVGRTGTYI-------VIDSM-----LQQIK--DKSTVNVLGFLKHIRTQRNYLV 1100

  Fly  1482 NGHSSSFAFQSETFTDE---KTTKYFQKEVESYEKLLENLHVKMLNGKTQLGAKWQELQQ----- 1538
            . ....:.|..:...:.   |.|:....::.||   :.::.:..:.|||:|..:::.:.|
  Rat  1101 Q-TEEQYIFIHDALLEAILGKETEVSSSQLHSY---VNSILIPGVGGKTRLEKQFKLITQCNAKY 1161

  Fly  1539 ----KLDKEAAANKRSTTIAKLFPEKNRSLDCLPYDHARVKL----DKQTDDYINAAYMKNLSAG 1595
                ...||  .||          ||||:...:|.:.|||.|    ..:..|||||:|:......
  Rat  1162 VECFSAQKE--CNK----------EKNRNSSVVPAERARVGLAPLPGMKGTDYINASYIMGYYRS 1214

  Fly  1596 CPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNELFDP---YWPQALDQPTHYDDYTVTCL 1657
             ..||:.|.|.|:|..|||.|||...::.:|.|.....|.:.   ||| :.::..:.:.:|||.:
  Rat  1215 -NEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEFVYWP-SREESMNCEAFTVTLI 1277

  Fly  1658 KVQQLSHCSEYQL-----KLSMHGADAVLDLSLLQLKQW-TKGAPA----QLLGV-AENALETHR 1711
            ...:|...:|.|:     .|.....|.||::...|..:| ...||.    :|:.| .|.||
  Rat  1278 SKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISSTFELINVIKEEAL---- 1338

  Fly  1712 QRCKAANAPQSPLIMNCLTGSERSELVAIGVCAIIATQNKQPILLNTIDVWSRICAQRQNSLRDS 1776
                   |...|.|::...|:     |:.|:...:.|.::|....|.:||:.  .|:..|.:|..
  Rat  1339 -------ARDGPTIVHDEYGA-----VSAGMLCALTTLSQQLENENAVDVFQ--VAKMINLMRPG 1389

  Fly  1777 AI--LEQSM---QIVLCNAHNVLNKRGIMTSYQMKMAPQVTAKEQQENKDPLNELDAL 1829
            ..  :||..   :.:|.......|..|.||.  .|....:||:|    .||...:::|
  Rat  1390 VFTDIEQYQFVYKAMLSLVSTKENGNGPMTG--DKNGAVLTAEE----SDPAESMESL 1441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mop	NP_648722.2	BRO1_HD-PTP_like	2..363	CDD:185762
		V_HD-PTP_like	368..702	CDD:185747	28/156 (18%)
		ALIX_LYPXL_bnd	421..699	CDD:290660	28/153 (18%)
		Med15	808..>1246	CDD:255446	98/542 (18%)
		Y_phosphatase	1558..1788	CDD:278528	68/252 (27%)
		PTPc	1559..1745	CDD:238006	58/203 (29%)
Ptprg	NP_599183.2	alpha_CARP_receptor_like	67..319	CDD:239396	35/187 (19%)
		FN3	348..438	CDD:238020	21/97 (22%)
		R-PTPc-G-1	845..1118	CDD:350505	49/328 (15%)
		R-PTP-G-2	1202..1406	CDD:350508	58/223 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900