DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mop and Ptpn23

DIOPT Version :9

Sequence 1:	NP_648722.2	Gene:	mop / 39610	FlyBaseID:	FBgn0036448	Length:	1833	Species:	Drosophila melanogaster
Sequence 2:	NP_476552.2	Gene:	Ptpn23 / 117552	RGDID:	619892	Length:	1666	Species:	Rattus norvegicus

Alignment Length:	1907	Identity:	525/1907 - (27%)
Similarity:	788/1907 - (41%)	Gaps:	456/1907 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEAVPRLHMLWFALKSSPEGTSFAALKKYIAEFYHEDPEAYSKEVHALETLRNQAMHTTKD--GA 63
            ||||||:.|:|..||.:.:....:|:||::.:.|.|:||||::|:..||.||..|:...:|  |.
  Rat     1 MEAVPRMPMIWLDLKEAGDFHFQSAVKKFVLKNYGENPEAYNEELKKLELLRQNAIRVARDFEGC 65

  Fly    64 PVMKRYYCQLHALQNRFPQ-LADRGIFTFKWKDLY--HSAVHEVTDLRFERAAVLFNIAALHTQS 125
            .|:::|..|||.||:|.|. ..........|.:::  .|..||  |:::|:|.:|:|:.|||:..
  Rat    66 SVLRKYLGQLHYLQSRVPMGSGQEAAVAITWTEIFSGKSVAHE--DIKYEQACILYNLGALHSML 128

  Fly   126 GASVTRGDVDGMKMACTHFQAAAWAYGELRERYANVNGGGDF---MTPELLVFQQQVCFAQAQEC 187
            ||...|...:|||::|||||.||.|:..|||.:...     |   |:.::|.....:...|||||
  Rat   129 GAMDKRVSEEGMKVSCTHFQCAAGAFAYLREHFPQA-----FSVDMSRQILTLNVNLMLGQAQEC 188

  Fly   188 ILEKSLIDNRKPHIVAKVTAQIVVYYGAALAALLTGGDDGPVAQVIDSSVYKLWKKYVRFKINYL 252
            :||||::||||..:||:::||:|.||..|..||     :.|....:...:.|.|||.|:.||.|.
  Rat   189 LLEKSMLDNRKSFLVARISAQVVDYYKEACRAL-----ENPDTASLLGRIQKDWKKLVQMKIYYF 248

  Fly   253 TCILYLYQGQHSEEKRQMGERVTLYQASWDKLEEARKESKGLPDQREINESLSFTADVVEAKRKN 317
            ..:.:|:.|:.:||:::.||||..:|::.|||.||.|.:||.||  .:.::|.|..||:..|..:
  Rat   249 AAVAHLHMGKQAEEQQKFGERVAYFQSALDKLNEAIKLAKGQPD--TVQDALRFAMDVIGGKYNS 311

  Fly   318 AKNENEFIYHEAVPELSTIAAVQGANLVNGIGFQVSDEEHAGPDIFARLVPMKAHEASSLYSEEK 382
            ||.:|:||||||||.|.|:..|:||.||..:....:|....||||||:||||.||||||||||||
  Rat   312 AKKDNDFIYHEAVPALDTLQPVKGAPLVKPLPVNPTDPAVTGPDIFAKLVPMAAHEASSLYSEEK 376

  Fly   383 AKLLRKYGALLEEKDTQLESYMSSLTLDNLNI-NEEQANKLPQGIVDRCAALNANKTAISDLVEA 446
            |||||:..|.:|:|:..|:.:|.|:.||...: |.:..|.:|..::::||||:.....:.:||::
  Rat   377 AKLLREMLAKIEDKNEVLDQFMDSMQLDPDTVDNLDAYNHIPPQLMEKCAALSVRPDTVKNLVQS 441

  Fly   447 MSQLAEITADVETNLGEISSMLEAEAKAEREFQSATGV------QRTPNAHITELSREFQKYSEA 505
            |..|:.:..|||.:|.:|..:||.:...|::.|...|.      .....|.:.|:.||:.||:|.
  Rat   442 MQVLSGVFTDVEASLKDIRDLLEEDELQEQKLQETLGQAGAGPGPSVTKAELGEVRREWAKYTEV 506

  Fly   506 HARAGESNNTLRKAMSLHVNNLKILARPLPEIQQLMPKLSSELNTTEIFRDVKLILNKVNEMKAQ 570
            |.:|..:|:.|.:||:|||.||::|:.||.:::..:|..:.......:.:::|.||.||.||:.|
  Rat   507 HEKASFTNSELHRAMNLHVGNLRLLSGPLDQVRAALPTPALTPEDKAVLQNLKRILAKVQEMRDQ 571

  Fly   571 RAQFHADLRIAINEDDITGKVIAHGGQEGLQALFATELGKHDKITELLDQNMVAQGNILQALTEN 635
            |......||..|.:||||..::.....| ::.||..:|.|:|::...|:||:.||.|:|:||||.
  Rat   572 RVSLEQQLRELIQKDDITASLVTTDHSE-MKKLFEEQLKKYDQLKVYLEQNLAAQDNVLRALTEA 635

  Fly   636 YAKAAPVLKTLQDVKQKREHFYSSLAASYDVYEDLLAKSAKGLEFYKKLAGNVQKLLTRFRSARD 700
            ..:.|.|.:.|.::.||......:|.|||:.||||:.||.:|.:||..|...|..||.|.:|...
  Rat   636 NVQYAAVRRVLSELDQKWNSTLQTLVASYEAYEDLMKKSQEGKDFYADLESKVAALLERAQSLCR 700

  Fly   701 VQSEERQQRMQSVKAATTPVVSKPIAETTPVPAVSSTPKLRDYLKAKAAMADASNPAYVPTVRPV 765
            .|...|||.:........|    |...|.|.|.:|.        :.:...|:|.:       :|.
  Rat   701 AQEAARQQLLDRELKKKAP----PPRPTAPKPLLSR--------REEGEAAEAGD-------QPE 746

  Fly   766 PVGSENPTQAACSYATAPPNEPPPPYSLTQQQYFDPSAAGYTNPMYQQQQQHIAPPAYKAQASPN 830
            .:.|..|..      .|.|..|.|         |..:||    |:      |.:|..:.....|.
  Rat   747 ELRSLPPDM------MAGPRLPDP---------FLGTAA----PL------HFSPGPFPGSTGPA 786

  Fly   831 SQTLHGALGQMNLQGQSQDNNQAGMAYNYGYPSGSVP----PLAYAPP------GTVPASSASQG 885
            :..|.|.|......|.:|          ...|..:||    |:.|..|      |.||.||...|
  Rat   787 THYLSGPLPPGTYSGPTQ----------LMQPRAAVPMAPGPVLYPAPVYTSELGLVPRSSPQHG 841

  Fly   886 LNIQQPLYVATSGNPVSVSNPSELPSTLQAPFVVNPMSNPYQTAAGYSGQAYQQVNAQAQQVTYP 950
            :                                   :|:||   ||.
  Rat   842 I-----------------------------------VSSPY---AGV------------------ 850

  Fly   951 TAPSGSSTGQSAQQPLGYAPSQGPQQQAGGYPQSQTPQQQVGAYQQQPLSG--YAQQLTPQQQTG 1013
                                  ||.|...|.|.:..||          .||  .|..:.|...|
  Rat   851 ----------------------GPPQPVVGLPSAPPPQ----------FSGPELAMAVRPATTT- 882

  Fly  1014 YSQSQAPQLQAPSYAQNQQSTGQA-QQQQTGYPQTPQQHLAGYAQSQQQATGYPQSQTSQQQTTG 1077
                 ...:|||..:......|.| ...|..:| .||.......|.|...|.|..|..::|..||
  Rat   883 -----VDSVQAPISSHMAPRPGPAPAPPQPCFP-VPQPVPQSVPQPQPLPTPYTYSIGTKQHLTG 941

  Fly  1078 YSQSQTPQQPLAYQQQPSGYPQQQQQQSLAPQQPSLYPSQAVQASPQPIPGQQATPPNAGQPLPY 1142
                     ||.....|.|.|.......:.||.|.       |..|||.|..|..||...||.|.
  Rat   942 ---------PLPQHHFPPGIPTSFPAPRIGPQPPP-------QLQPQPQPQPQPQPPPQPQPQPQ 990

  Fly  1143 PQ---------------QYTDPNAAPAPAPGVSSVPSPVPVPTPAPTSSQAQVPTSPHPSATYTS 1192
            ||               .:..|:..|:.|||:.:.|.|.|. ||.|     .|...|.|:.....
  Rat   991 PQPQRPVFGPQPTQQPLPFQHPHLFPSQAPGILTPPPPYPF-TPQP-----GVLGQPPPTRHTQL 1049

  Fly  1193 YSNHPGYSFNPQTGKYEYSSGYQQDTSSLKGSQASQSYQFSQSGKQQSVGTTDSEIASRSNTATG 1257
            |...|..:..|.:|
  Rat  1050 YPGPPPDTLPPHSG--------------------------------------------------- 1063

  Fly  1258 FDSPIVSHTKVNMAAKDSTSAIEGNESSNYYSTPYGYLGSVNPQQQPTPAPPSNSTASIYMQSGA 1322
                                           :.|:           |:|.||.......|..:
  Rat  1064 -------------------------------ALPF-----------PSPGPPHPHPTLAYGPA-- 1084

  Fly  1323 SSTAETQTTSSGVPYASSAALTKVEPKPEALPPKVTSNVDLLSDLDIDCSVAVPPPMLPQPVLQP 1387
                                     |.|..|.|:.|           ..|:..||| ..||...|
  Rat  1085 -------------------------PSPRPLGPQAT-----------PVSIRGPPP-ANQPAPSP 1112

  Fly  1388 QVVATPTPPASQVSVPVKVESVAEHAAPATAEIPVAATEGTAQTPVTIPSGPKCASLDNLSNCSD 1452
            .:|.:|.|......||         :.|.|||.|.....|.|                    .:|
  Rat  1113 HLVPSPAPSPGPGPVP---------SRPPTAEPPPCLRRGAA--------------------AAD 1148

  Fly  1453 LSSLENFDWDSVSVTHSVSE---------KQTKASATANGHSSSF-AFQSETFTDEKTTKYFQKE 1507
            |.|      .|....|..::         :.||..|.......:. ..:.:.:...:..:..|:|
  Rat  1149 LLS------SSPESQHGGTQPPGGGQPLLQPTKVDAAEGRRPQALRLIEQDPYEHPERLQKLQQE 1207

  Fly  1508 VESYEKLLENLHVKMLNGKTQLGAKWQELQQKLDKEAAANKRSTTIAKLFPEKNRSLDCLPYDHA 1572
            :||:.        ..|.....|.|.|:|||:.  :|..|..||..||:.:..|||..|.:|||..
  Rat  1208 LESFR--------GQLGDAGALDAVWRELQEA--QEHDARGRSIAIARCYSLKNRHQDVMPYDSN 1262

  Fly  1573 RVKLDKQTDDYINAAYMKNLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNEL--- 1634
            ||.|....||||||:.::.||..||..:..|.|.|.|..|||.|:..:|...:|.|.:..|:
  Rat  1263 RVVLRSGKDDYINASCVEGLSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQ 1327

  Fly  1635 -FDPYWPQALDQPTHYDDYTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQL--KQWTK--- 1693
             ...|:|....||..:...:|....|:...  :..:..||:...|..|..||:.|  ..|.:
  Rat  1328 KVARYFPIERGQPMVHGALSVALSSVRTTD--THVERVLSLQFRDQSLKRSLVHLHFPTWPELGL 1390

  Fly  1694 -GAPAQLLGVAENALETH----RQRCKAANAP-QSPLIMNCLTGSERSELVAIGVCAI--IATQN 1750
             .:|..||...:   |.|    .||      | .:|::::|.:|..|:...|:...|:  :...:
  Rat  1391 PDSPGNLLRFIQ---EVHAHYLHQR------PLHTPIVVHCSSGVGRTGAFALLYAAVQEVEAGS 1446

  Fly  1751 KQPILLNTIDVWSRICAQRQNSLRDSAILEQSMQIVLCNAHNVLNKRGIMTSYQMKMAPQVTAKE 1815
            ..|.|...:   .|:..||::.|::...|:...:.::.:...||.:.|:....:...:..|:.|.
  Rat  1447 GIPELPQLV---RRMRQQRKHMLQEKLHLKFCHEALVRHVEQVLQRHGVPPPGKPVASMSVSQKS 1508

  Fly  1816 Q--QENKD-------PLNELDA 1828
            .  |:::|       |::.:.|
  Rat  1509 HLPQDSQDLVLGGDVPISSIQA 1530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mop	NP_648722.2	BRO1_HD-PTP_like	2..363	CDD:185762	145/368 (39%)
		V_HD-PTP_like	368..702	CDD:185747	127/340 (37%)
		ALIX_LYPXL_bnd	421..699	CDD:290660	98/283 (35%)
		Med15	808..>1246	CDD:255446	94/465 (20%)
		Y_phosphatase	1558..1788	CDD:278528	67/246 (27%)
		PTPc	1559..1745	CDD:238006	59/200 (30%)
Ptpn23	NP_476552.2	BRO1_HD-PTP_like	2..357	CDD:185762	145/368 (39%)
		V_HD-PTP_like	362..702	CDD:185747	127/340 (37%)
		ALIX_LYPXL_bnd	417..703	CDD:290660	98/286 (34%)
		Y_phosphatase	1250..1480	CDD:278528	67/243 (28%)
		PTPc	1250..1479	CDD:238006	67/242 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	192	1.000	Domainoid score	I3133
eggNOG	1	0.900	-	-		E1_KOG2220
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	430	1.000	Inparanoid score	I1667
OMA	1	1.010	-	-		QHG46611
OrthoDB	1	1.010	-	-		D498845at33208
OrthoFinder	1	1.000	-	-		FOG0006256
OrthoInspector	1	1.000	-	-		oto98042
orthoMCL	1	0.900	-	-		OOG6_104542
Panther	1	1.100	-	-	LDO	PTHR23030
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3427
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840