DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mop and ptpn23

DIOPT Version :9

Sequence 1:	NP_648722.2	Gene:	mop / 39610	FlyBaseID:	FBgn0036448	Length:	1833	Species:	Drosophila melanogaster
Sequence 2:	XP_031759128.1	Gene:	ptpn23 / 100217320	XenbaseID:	XB-GENE-996513	Length:	1934	Species:	Xenopus tropicalis

Alignment Length:	1978	Identity:	595/1978 - (30%)
Similarity:	906/1978 - (45%)	Gaps:	368/1978 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEAVPRLHMLWFALKSSPEGTSFAALKKYIAEFYHEDPEAYSKEVHALETLRNQAMHTTKD--GA 63
            ||||||:.|:|..||...|.....|:|:::.:.|.|:||.|::|:..|:.||..|::..:|  |.
Frog     1 MEAVPRMPMIWLDLKEPGEFAFQPAVKQFVLKNYGENPENYNEELKKLDQLRQSAVNVPRDFEGC 65

  Fly    64 PVMKRYYCQLHALQNRFPQLADR-GIFTFKWKDLY--HSAVHEVTDLRFERAAVLFNIAALHTQS 125
            .|:::|:.|||.||:|.|..::: ......|.:::  .:..||  |:::|:|.||:|:.|||:..
Frog    66 SVLRKYFGQLHYLQSRIPMGSEQEASVPVTWTEIFSGKTVTHE--DIKYEQACVLYNLGALHSML 128

  Fly   126 GASVTRGDVDGMKMACTHFQAAAWAYGELRERYA---NVNGGGDFMTPELLVFQQQVCFAQAQEC 187
            ||...|...:|||::|||||.||.|:..||:.:|   :|:     |:.::|.....:...|||||
Frog   129 GAMDKRVSEEGMKVSCTHFQCAAGAFAYLRDHFAHSYSVD-----MSHQILNLNINLMLGQAQEC 188

  Fly   188 ILEKSLIDNRKPHIVAKVTAQIVVYYGAALAALLTGGDDGPVAQVIDSSVYKLWKKYVRFKINYL 252
            :||||::||||..:||:::||:|.||..|..||    ::...|.:: ..:.|.|||.|:.||.|.
Frog   189 LLEKSMLDNRKSFLVARISAQVVDYYKEACRAL----ENSETASLL-GKIQKDWKKLVQMKIYYF 248

  Fly   253 TCILYLYQGQHSEEKRQMGERVTLYQASWDKLEEARKESKGLPDQREINESLSFTADVVEAKRKN 317
            ..|.:|:..:.:||:::.||:|...|::.|||.||.|:|||.|  ..:.|:|.||.||:..|..:
Frog   249 ASIAHLHMAKQAEEQQKYGEQVAYLQSALDKLNEAIKQSKGQP--ATVQEALRFTMDVIGGKFNS 311

  Fly   318 AKNENEFIYHEAVPELSTIAAVQGANLVNGIGFQVSDEEHAGPDIFARLVPMKAHEASSLYSEEK 382
            ||.:|:|||||:||.|.|:.||:||.||..:....:|....|||||::||||.||||||||||||
Frog   312 AKKDNDFIYHESVPALDTLQAVKGAPLVKALPVNPTDPAVTGPDIFSKLVPMAAHEASSLYSEEK 376

  Fly   383 AKLLRKYGALLEEKDTQLESYMSSLTLDNLNI-NEEQANKLPQGIVDRCAALNANKTAISDLVEA 446
            |||||:..:.:|.|:..|:.:..||.||...: |.|..:.:|..::::||||:.....|..||::
Frog   377 AKLLREVMSKIEAKNEILDQFTDSLQLDPDTVDNLEMYSHIPPALMEKCAALSVRPDTIKSLVQS 441

  Fly   447 MSQLAEITADVETNLGEISSMLEAEAKAEREFQSATGVQRTPNA----HITELSREFQKYSEAHA 507
            |..|:.:..|||.:|.::..:|:.....|::.|...|.|..|.|    .|.::|:|:.||.|.|.
Frog   442 MQVLSGVYTDVEASLKDVKEILDEHEIQEKKLQEEVGKQPAPPAPLSPSIEDVSKEWGKYMEVHE 506

  Fly   508 RAGESNNTLRKAMSLHVNNLKILARPLPEIQQLMPKLSSELNTTEIFRDVKLILNKVNEMKAQRA 572
            :|..:|..|.|||:||::||::|:.||.::||.:|......:...:.:::|.|||||.||:.||.
Frog   507 KASFTNTELHKAMNLHISNLRLLSGPLDQLQQQLPAPVLTEDDKAVLQNLKKILNKVQEMREQRQ 571

  Fly   573 QFHADLRIAINEDDITGKVIAHGGQEGLQALFATELGKHDKITELLDQNMVAQGNILQALTENYA 637
            .....||..|.:||||..::.....| ::.|||.:|.|:|::...::||:.||.|||:||||...
Frog   572 SLEQQLRDTIQQDDITTSLVTTDRSE-MKKLFAEQLKKYDQLKVYVEQNLSAQENILKALTEANV 635

  Fly   638 KAAPVLKTLQDVKQKREHFYSSLAASYDVYEDLLAKSAKGLEFYKKLAGNVQKLLTRFRSARDVQ 702
            |.|||.|.:.:.:||..|...:|.:||:.||||:.||.:|.:||..|...|.||:.:.|:|.|..
Frog   636 KYAPVRKIITEAEQKWNHTVQTLISSYEAYEDLMKKSQEGKDFYSDLESKVAKLVEKSRAAFDAA 700

  Fly   703 SEERQQRMQ-SVKAATTPVVSKPIAETTPVPAVSSTP---------------------------K 739
            ...|||.:: .:|....|   :|   |.|.||:...|                           :
Frog   701 QANRQQVLERELKKRPPP---RP---TAPKPALQKKPSDVDLASLPLSDLASLQHSLFYSELPEE 759

  Fly   740 LR-----------DYLKAKAAMADASNPAYVPTVRPVPVGSENPTQAACSYATAPPNEPPPPYSL 793
            |:           |.|.|....|...:|.|..| :|..|.:..|::.| |...|.|:..|    .
Frog   760 LKSLPPEALLAHLDRLSADTLDAFPPDPTYGGT-KPTGVNAYRPSRTA-SAPVADPHSVP----F 818

  Fly   794 TQQQYFDP--------SAAGYT-----------NPMYQQQQQHIAPPAYKAQASPNSQT------ 833
            ||..:|:|        ...||.           ||...|.:|...|.|...||..:|.:
Frog   819 TQSPHFNPMPGHTPQYGGVGYPANAFPPVMYNGNPQLSQFKQSAPPQANVPQAPVSSSSPQNPRM 883

  Fly   834 -LHGALGQMNLQGQSQDNNQAGMAYNYGYPSGSVP-PLAYAPPGTVPASSASQGLNIQQPLYVAT 896
             |.||:|::::|.:                  :|| |.||| |||:|....|       |.:|
Frog   884 YLAGAMGRVHVQPE------------------AVPMPPAYA-PGTMPQQRVS-------PQHV-- 920

  Fly   897 SGNPVSVSNPSELPSTLQAPFVVNPMSNPYQTAAGYS-GQAYQQVNAQAQQVTYPT---APSGSS 957
                       .:|:|..||  |.|..|   |..|:: ||...........|.|..   ||.||.
Frog   921 -----------PMPATAAAP--VAPQFN---TGVGFAVGQQVSSSGVLPNAVNYSAAGYAPQGSP 969

  Fly   958 TGQSAQQPLGYAPSQGPQQQA--GGYPQSQTP---QQQVGAYQQQPLSGYAQQLTPQQQTGYSQS 1017
            ...|.      ||..|.|.||  |..|.:.|.   |..:.:|....|.|..|.:||
Frog   970 RIHST------APVSGLQPQAAQGIRPATTTVNSIQGPISSYTTPRLPGPNQTITP--------- 1019

  Fly  1018 QAPQLQAPSYAQNQQSTGQAQQQQTGYPQTPQQHLAGYAQSQQQATGYPQSQTSQQQTTGYSQSQ 1082
            ..|.::|                |:|| ..|..|   .|..|....|.||....|     |.|
Frog  1020 TLPPIRA----------------QSGY-MAPPVH---SAMGQPAPYGCPQGAVPQ-----YPQ-- 1057

  Fly  1083 TPQQPLAYQQQPSGYPQQQQQQSLAPQQPSLYPSQAVQASPQPIPGQQ--ATPPNAGQPLPYPQQ 1145
             |.:|:....||   ||..|    ||.|..   .:...|.|..:|.||  |.||   || |:..|
Frog  1058 -PPRPILPHAQP---PQLFQ----APGQTQ---HRLDSARPPSVPNQQQYAPPP---QP-PFSAQ 1107

  Fly  1146 YTDPNAAPAPAPGVSSVPSPVPVPTPAPTSSQAQVPTSPHPSATYTSYSNHPGYSFNPQTGKYEY 1210
            ...|...|.|     .:..|..||...|      ||..||    :..:.:|.. .|..|.|....
Frog  1108 MRPPLNHPQP-----PIYQPPVVPQVTP------VPAQPH----FQQHFHHQN-PFPVQPGILPL 1156

  Fly  1211 SSGYQQDTSSLKGSQASQSYQFSQSGKQQSVGTTDSEIASRSNTATGFDSPIVSHTKVNMAAKDS 1275
            ..|             :|.:...|.|.|:                    .|:.||.|:
Frog  1157 QPG-------------AQPHVPPQLGPQR--------------------FPVASHDKL------- 1181

  Fly  1276 TSAIEGNESSNYYSTPYGYLGSV----NPQQQPTPAPPSNSTASIYMQSGASSTAETQTTSSGVP 1336
                 ..:|...:|....:.|:|    .|..||.|.|...:|..|:....|.|   ..:|..|:.
Frog  1182 -----PPQSLPPHSAGMNFPGTVPRPAAPMAQPIPPPMCQATPQIHPHPAAVS---MHSTPPGLN 1238

  Fly  1337 YASSAALTKVEP-KPEALPPKVTSN-VDLLSDLDIDCSVAVP-----------PPM--LPQPVLQ 1386
            ...::|:..|.| :|...||...:| :..|:.:.:....|.|           |.|  ||..|:.
Frog  1239 APIASAMPFVPPARPTVPPPNSLANQMPALNQMPMGGPQATPAIPHHIQAPSSPAMSHLPGAVIV 1303

  Fly  1387 PQVVATPTP-PASQVSVPVKVESVAEHAAPATAEI----PVAATEGTAQTPVTIPSGP-----KC 1441
            ....|.|:| |:.|.|:.::.::......||||.|    |.:.|.||  ||:|..||.     :.
Frog  1304 SGAAAMPSPAPSPQPSLVLQSQTSLPTTGPATATIPQRPPPSLTPGT--TPLTQGSGEVVFQRQS 1366

  Fly  1442 ASLDNLSNCSDLSSLENFDWDSVSVTHSVSEKQTKASATANGHSSSF-AFQSETFTDEKTTKYFQ 1505
            :|.|:|.:    ||.|:....|.:.......:.|||.........:. ..:::.:...:......
Frog  1367 SSTDDLLS----SSPESQHGSSKTSVGQPLLQPTKADLKEGQKPKAIQLIENDPYEKPEHVMRLL 1427

  Fly  1506 KEVESYEKLLENLHVKMLNGKTQLGAKWQELQQKLDKEAAANKRSTTIAKLFPEKNRSLDCLPYD 1570
            .|::.:..::|.|...:....|||.:.|:|.|:..:||  |.::|..||:.:..|||..|.:|||
Frog  1428 SELDRFRVVVEALDKPVPGASTQLDSMWKEFQEAQEKE--ARQQSIAIARCYTMKNRHQDIMPYD 1490

  Fly  1571 HARVKLDKQTDDYINAAYMKNLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNELF 1635
            ..|:.|....||||||:.:::||:.||:.|..|.|...|.:|||.||..:|...:|.|.:..|:.
Frog  1491 KNRIILQSGKDDYINASKIEDLSSYCPSIIATQAPLVGTASDFWLMIHEQKVSLIVMLVSEQEIE 1555

  Fly  1636 DP----YWP----QALDQPTH-YDDYTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSL--LQLK 1689
            ..    |:|    ||:   .| :...|:|..||..:    ..:..||:...|..|..|:  ||..
Frog  1556 KQKVLRYFPLERGQAM---VHGHISLTLTSQKVTDI----HVERVLSLQYKDQSLKRSIIHLQFT 1613

  Fly  1690 QWTK-GAPAQLLGVAENALETH----RQRCKAANAP-QSPLIMNCLTGSERSELVAIGVCAI--I 1746
            .|.: |.|.....:.....|.|    .||      | .:|::::|.:|..|:....:...|:  :
Frog  1614 SWPELGLPDSKGNLLRFIQEVHSHYLHQR------PLHTPIVVHCSSGVGRTGAFCLMYAAMQEV 1672

  Fly  1747 ATQNKQPILLNTIDVWSRICAQRQNSLRDSAILEQSMQIVLCNAHNVLNKRGIMTSYQMKMAPQ- 1810
            ...|..|.|...:   .::..||:..|::...|:...:.||.:|..||.:.|:.|....|  ||
Frog  1673 EAGNGIPDLAELV---KKMRQQRKYMLQEKIHLKFCYEAVLKHAEQVLQRHGVCTPSSSK--PQH 1732

  Fly  1811 ------VTAKEQQE----NKDPLNELDA 1828
                  .|.::.|:    ...|::.:.|
Frog  1733 STPLKLYTVQDPQDIVLGGDMPISSIQA 1760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mop	NP_648722.2	BRO1_HD-PTP_like	2..363	CDD:185762	144/368 (39%)
		V_HD-PTP_like	368..702	CDD:185747	134/338 (40%)
		ALIX_LYPXL_bnd	421..699	CDD:290660	104/281 (37%)
		Med15	808..>1246	CDD:255446	118/456 (26%)
		Y_phosphatase	1558..1788	CDD:278528	69/248 (28%)
		PTPc	1559..1745	CDD:238006	60/202 (30%)
ptpn23	XP_031759128.1	BRO1_HD-PTP_like	2..357	CDD:185762	144/368 (39%)
		V_HD-PTP_like	362..699	CDD:185747	133/337 (39%)
		PHA03247	<763..1227	CDD:223021	154/631 (24%)
		Atrophin-1	1162..>1348	CDD:397323	49/220 (22%)
		PTP-N23	1503..1707	CDD:350387	57/219 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	289	1.000	Domainoid score	I1543
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	601	1.000	Inparanoid score	I943
OMA	1	1.010	-	-		QHG46611
OrthoDB	1	1.010	-	-		D498845at33208
OrthoFinder	1	1.000	-	-		FOG0006256
OrthoInspector	1	1.000	-	-		oto104732
Panther	1	1.100	-	-	LDO	PTHR23030
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R147
SonicParanoid	1	1.000	-	-		X3427
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110