Protein Alignment mop and PDCD6IP

DIOPT Version :10

• Sequence 1: NP_648722.2
• Gene: mop / 39610
• FlyBaseID: FBgn0036448
• Length: 1833
• Species: Drosophila melanogaster
• Sequence 2: NP_001155901.1
• Gene: PDCD6IP / 10015
• HGNCID: 8766
• Length: 873
• Species: Homo sapiens
• Alignment Length: 1044
• Identity: 240/1044 - (22%)
• Similarity: 416/1044 - (39%)
• Gaps: 239/1044 - (22%)

  Fly    14 LKSSPEGTSFAALKKYIAEFY---HEDPEAYSKEVHALETLRNQAMHTTKDGAPVMK-------- 67
            ||.:.|......|.|:|.:.|   .|:...|.:....|..||..|:     |.|:.|
Human     9 LKKTSEVDLAKPLVKFIQQTYPSGGEEQAQYCRAAEELSKLRRAAV-----GRPLDKHEGALETL 68

  Fly    68 -RYYCQLHALQNRFPQLADRGIFTFKWKDLYH-------SAVHEVTDLRFERAAVLFNIAALHTQ 124
             |||.|:.:::.:||...::...||.|||.:.       |....:..|.:|::.||||.|||.:|
Human    69 LRYYDQICSIEPKFPFSENQICLTFTWKDAFDKGSLFGGSVKLALASLGYEKSCVLFNCAALASQ 133

  Fly   125 SGASVTRGDVDGMKMACTHFQAAAWAYGELRE-------RYANVNGGGDFMTPELLVFQQQVCFA 182
            ..|.....:.:|:|:|..|:|.|:.|:..::|       |...|:     ::|:.:.....:..|
Human   134 IAAEQNLDNDEGLKIAAKHYQFASGAFLHIKETVLSALSREPTVD-----ISPDTVGTLSLIMLA 193

  Fly   183 QAQECILEKSLIDNRKPHIVAKVTAQIVVYYGAALAALLTGGDDGPVAQVIDSSVYK-LWKKYVR 246
            ||||....|:..|..|..|:||:..|...|:|.|                .....|| ...||..
Human   194 QAQEVFFLKATRDKMKDAIIAKLANQAADYFGDA----------------FKQCQYKDTLPKYFY 242

  Fly   247 FK-----INYLTCILYLYQGQH----SEEKRQMGERVTLYQASWDKLEEARKESKGLPDQREINE 302
            |:     :....||:......|    ::::::.||.:.       :|:.|.:..|.:..:.:...
Human   243 FQEVFPVLAAKHCIMQANAEYHQSILAKQQKKFGEEIA-------RLQHAAELIKTVASRYDEYV 300

  Fly   303 SLSFTADVVEAKRKNAKNENEFIYHEAVPELSTIAAVQGANLVNGIGFQVSDEEHAGPDIFARLV 367
            ::...:|.:......||.:|:||||:.||:|..:..:..|.||......|...:.. .|:|.::|
Human   301 NVKDFSDKINRALAAAKKDNDFIYHDRVPDLKDLDPIGKATLVKSTPVNVPISQKF-TDLFEKMV 364

  Fly   368 PMKAHEASSLYSEEKAKLLRKYGALLEEKDTQLESYMSSLTLDNLNINEEQANKLPQGIVDRCAA 432
            |:...::.:.|::.||.|:.:..|.:.|..|.....::||.|. ..|.:...:.:||.|:.:..:
Human   365 PVSVQQSLAAYNQRKADLVNRSIAQMREATTLANGVLASLNLP-AAIEDVSGDTVPQSILTKSRS 428

  Fly   433 L--NANKTAISDLVEAMSQLAEITADVETNLGEISSMLEAEAKAEREFQS--ATGVQRTPNAHIT 493
            :  ......:..|::.:.:|.:...::   |.|...:|:.|...:.:.::  ....||||:..:.
Human   429 VIEQGGIQTVDQLIKELPELLQRNREI---LDESLRLLDEEEATDNDLRAKFKERWQRTPSNELY 490

  Fly   494 E-LSREFQKYSEAHARAGESNNTLRKAMSLHVNNLKILARPLPEIQQLMPKL--SSELNTTEIFR 555
            : |..|...:.....:|.:::..:::....|.:.:.:|.:|.||:...:|..  :..:..:|:..
Human   491 KPLRAEGTNFRTVLDKAVQADGQVKECYQSHRDTIVLLCKPEPELNAAIPSANPAKTMQGSEVVN 555

  Fly   556 DVKLILNKVNEMKAQRAQFHADLRIAINEDDITGKVIAHGGQEGL---QALFATELGKHDKITEL 617
            .:|.:|:.::|:|.:|.....||: ::| .|:|.|.:....|:|:   :||..|||   |::
Human   556 VLKSLLSNLDEVKKEREGLENDLK-SVN-FDMTSKFLTALAQDGVINEEALSVTEL---DRV--- 612

  Fly   618 LDQNMVAQGNILQALTENYAKAAPVLKTLQ-------DVKQK------REHFYSSLAASYDVYED 669
                   .|.:...:.|:..|...:||.:|       .:||.      ||....:||.:||.:.:
Human   613 -------YGGLTTKVQESLKKQEGLLKNIQVSHQEFSKMKQSNNEANLREEVLKNLATAYDNFVE 670

  Fly   670 LLAKSAKGLEFYKKLAGNVQKLLTRFRS-ARDVQSEERQQRMQSVKAATTPVVSKPIAETTPVPA 733
            |:|...:|.:||.:|.    ::|.||:: ..|:....:.:|.:.:|.....:..:|.|.:.|.||
Human   671 LVANLKEGTKFYNELT----EILVRFQNKCSDIVFARKTERDELLKDLQQSIAREPSAPSIPTPA 731

  Fly   734 VSSTPKLRDYLKAKAAMADASNPAYVPTVRPVPVGSENPTQAACSYATAPPNEPPPPYSLTQQQY 798
            ..|:                            |.|...||....:..|.||.:|.||
Human   732 YQSS----------------------------PAGGHAPTPPTPAPRTMPPTKPQPP-------- 760

  Fly   799 FDPSAAGYTNPMYQQQQQHIAPPAYKAQASPNSQTLHGALGQMNLQGQSQDNNQAGMAYNYGYPS 863
                    ..|         .||...|..:| |.|....:|                       :
Human   761 --------ARP---------PPPVLPANRAP-SATAPSPVG-----------------------A 784

  Fly   864 GSVPPLAYAPPGTVPASSASQGLNIQQPLYVATSGNPVSVSNPSELPSTLQAPFVVNPMSNPYQT 928
            |:..|.....||:.|...|      |.|.|....|          .|...|.|.   ||
Human   785 GTAAPAPSQTPGSAPPPQA------QGPPYPTYPG----------YPGYCQMPM---PM------ 824

  Fly   929 AAGYSGQAYQQVNAQAQQVTYPTAPSGSSTGQSAQQPLGYAPSQGPQQQAGGYPQSQTPQQQVGA 993
              ||:..||.|.|     :.||..         ..|..|.||..||||.:  ||..|.|||..
Human   825 --GYNPYAYGQYN-----MPYPPV---------YHQSPGQAPYPGPQQPS--YPFPQPPQQSY-- 869

  Fly   994 YQQQ 997
            |.||
Human   870 YPQQ 873

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mop	NP_648722.2	BRO1_HD-PTP_like	2..363	CDD:185762	94/384 (24%)
		V_HD-PTP_like	368..702	CDD:185747	78/357 (22%)
		Glutenin_hmw	<795..1261	CDD:367362	48/203 (24%)
		PHA03247	<1329..1443	CDD:223021
		PRK12323	<1378..1540	CDD:481241
		Y_phosphatase	1558..1788	CDD:459674
PDCD6IP	NP_001155901.1	BRO1_Alix	2..350	CDD:185763	92/373 (25%)
		V_Alix	365..703	CDD:185748	78/360 (22%)
		Interaction with SDCBP. /evidence=ECO:0000269|PubMed:22660413	423..873		127/593 (21%)
		Self-association	508..873		114/505 (23%)
		PHA03247	<717..871	CDD:223021	61/275 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	718..814		34/188 (18%)
		Interaction with TSG101	722..725		1/2 (50%)
		Interaction with CEP55. /evidence=ECO:0000269|PubMed:18641129	806..811		2/4 (50%)
		Amelogenin	<819..>873	CDD:197891	27/82 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	837..873		17/48 (35%)
		Essential to promote virus budding	869..873		1/5 (20%)