Protein Alignment Mgat4b and MGAT4C

DIOPT Version :10

• Sequence 1: NP_648721.1
• Gene: Mgat4b / 39609
• FlyBaseID: FBgn0036447
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_001338211.1
• Gene: MGAT4C / 25834
• HGNCID: 30871
• Length: 516
• Species: Homo sapiens
• Alignment Length: 506
• Identity: 121/506 - (23%)
• Similarity: 205/506 - (40%)
• Gaps: 99/506 - (19%)

  Fly    11 CLPGLIIVSY---LVCALLYFGMDITKIEPVE--PRVVK-------NKTKVPRMYAKTINHDG-- 61
            ||.....||:   ||..||:..:.|.....:|  .::::       |..:....:....|..|
Human    57 CLRKRSTVSFLGVLVIFLLFMNLYIEDSYVLEGDKQLIRETSTHQLNSERYVHTFKDLSNFSGAI 121

  Fly    62 --NWETIVTNPELKPRYRVGGGRTGVQFVIGVPTVLRPKKNYVLQTVDCLIRRMTPEQRDNCLIV 124
              .:..:...|..:.||          ..||:.:|.|.|.||:|:|:..:..:.:.|:.....:|
Human   122 NVTYRYLAATPLQRKRY----------LTIGLSSVKRKKGNYLLETIKSIFEQSSYEELKEISVV 176

  Fly   125 IFVGETKLQFAKFIVRELRVNHSTHMQAGLIDVIAPPLNYYPNFSRLHITLNDDPQRVQWRTKQN 189
            :.:.:....:...:|:::....:.|:.||.:.||..|..|||....|....||...||::|:|||
Human   177 VHLADFNSSWRDAMVQDITQKFAHHIIAGRLMVIHAPEEYYPILDGLKRNYNDPEDRVKFRSKQN 241

  Fly   190 LDYIYLMSYAKSRGLYYLQLEDDVMANVGFMDYIQK-FAVLHGSFRIAQQIDWIVMSFSELGFIG 253
            :||.:|:::..:...||:.|||||..:..|:..|:| .|.|.|::       |:.:.||:||:||
Human   242 VDYAFLLNFCANTSDYYVMLEDDVRCSKNFLTAIKKVIASLEGTY-------WVTLEFSKLGYIG 299

  Fly   254 KLFRTSVLSSFVAYLKLFYNDQPIDWLLQSFVTLQSCRWDSVSDPECQRDFESRLLRSSQSQFQH 318
            ||:.:..|.....:|.:||.:.|.||||..|..|.:               :..::|...|.|||
Human   300 KLYHSHDLPRLAHFLLMFYQEMPCDWLLTHFRGLLA---------------QKNVIRFKPSLFQH 349

  Fly   319 MGAQSSLADKQQYQKDAFF---NHNFARQRLRHLRQPLNLIATHRNSLLKHNLDLV-------EG 373
            ||..||....:...||..|   :.:........|...:|:...:..|....::|..       .|
Human   350 MGYYSSYKGTENKLKDDDFEEESFDIPDNPPASLYTNMNVFENYEASKAYSSVDEYFWGKPPSTG 414

  Fly   374 ETFIWIY-MPRMPKMMKYLITNQFKQTQLHIRNAKDTAHNLAEFNIELVKGSPTLVANSSSTRQC 437
            :.|:.:: .|.:.|.:|.....:.:|..:....|.|...|               |..|...|||
Human   415 DVFVIVFENPIIIKKIKVNTGTEDRQNDILHHGALDVGEN---------------VMPSKQRRQC 464

  Fly   438 ------------GFVMSHTVQSFAERDGKAELPYN---YMYYYIKEEPEGL 473
                        .|.||...|         ::|::   ...|..|.:.|.|
Human   465 STYLRLGEFKNGNFEMSGVNQ---------KIPFDIHCMRIYVTKTQKEWL 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mgat4b	NP_648721.1	Glyco_transf_54	30..337	CDD:461384	85/320 (27%)
		putative TM2 helix	243..263	CDD:409189	9/19 (47%)
MGAT4C	NP_001338211.1	putative TM1 helix	67..79	CDD:409189	4/11 (36%)
		Glyco_transf_54	102..368	CDD:461384	83/297 (28%)