DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9384 and MGAT4A

DIOPT Version :9

Sequence 1:	NP_001261847.1	Gene:	CG9384 / 39608	FlyBaseID:	FBgn0036446	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_036346.1	Gene:	MGAT4A / 11320	HGNCID:	7047	Length:	535	Species:	Homo sapiens

Alignment Length:	498	Identity:	205/498 - (41%)
Similarity:	302/498 - (60%)	Gaps:	44/498 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 RQLLRNASH-ISK---------------GGSANGS-----------------MARSQNIRLPNAY 135
            ::.||.|.| ||:               |...|||                 :...:::::|:.|
Human    45 KERLRIAEHRISQRSSELNTIVQQFKRVGAETNGSKDALNKFSDNTLKLLKELTSKKSLQVPSIY 109

  Fly   136 HFLPHLLDDAGSLRPAYLQSKGRSDVSIVLGVPTVRREKQSYLLGTLHNLIENMNDEEQNETLII 200
            :.|||||.:.|||:||.....||:.||||:|:|||:||.:|||:.|||:||:|:..||:.:.:|:
Human   110 YHLPHLLKNEGSLQPAVQIGNGRTGVSIVMGIPTVKREVKSYLIETLHSLIDNLYPEEKLDCVIV 174

  Fly   201 VYIGETDMESVQLIARQIESSFDQHVESGLIDIIAPAPSYYPNFERLRITLNDPLERVKWRSKQN 265
            |:|||||::.|..:...:|..|.:.:.|||:::|:|..||||:...|:.|..|..|||:||:|||
Human   175 VFIGETDIDYVHGVVANLEKEFSKEISSGLVEVISPPESYYPDLTNLKETFGDSKERVRWRTKQN 239

  Fly   266 LDFAYLMAYAHSKGTFYVQLEDDILTKRQFITTMKKFALIKSALTKPDQPEWFVLDFCQLGFIGK 330
            ||:.:||.||..||.:|:||||||:.|:.:..|:|.|||..|:      .||.:|:|.|||||||
Human   240 LDYCFLMMYAQEKGIYYIQLEDDIIVKQNYFNTIKNFALQLSS------EEWMILEFSQLGFIGK 298

  Fly   331 MFKSAELPYLITYFQMFYNDKPVDWLLTYFIESKVCRTDKDQKHCNAEKAKYWQHFRKSLFQHIG 395
            ||::.:|..::.:..|||.:||:||||.:.:..|||..:||.|||:.:||.....||.|||||:|
Human   299 MFQAPDLTLIVEFIFMFYKEKPIDWLLDHILWVKVCNPEKDAKHCDRQKANLRIRFRPSLFQHVG 363

  Fly   396 TSSSLKGKVQKLKDKQFGSKVPQYYAHTH-NPPALVKSNIAPYKNYLLQRAYRGESYFWGLLPQP 459
            ..|||.||:|||.||.:   :.......| ||||.|.:::..|:.:.|::.|.||.:||.:.|..
Human   364 LHSSLSGKIQKLTDKDY---MKPLLLKIHVNPPAEVSTSLKVYQGHTLEKTYMGEDFFWAITPIA 425

  Fly   460 GDLVQIIFERPTQLRHYLFRSGNSEHPSDRFYNTTVELLPADTLSENSSVWSSYNTTTDGYLVVG 524
            ||.:...|::|..:..|||.|||.|||.|...|||||:||..:.....|..:......|||..:|
Human   426 GDYILFKFDKPVNVESYLFHSGNQEHPGDILLNTTVEVLPFKSEGLEISKETKDKRLEDGYFRIG 490

  Fly   525 SFDSMGVAEGLLDAKIGAIKELRLHVHSDSENWALLSEIELQE 567
            .|:: |||||::|..:..|...||.|..:|..||:|:||.:::
Human   491 KFEN-GVAEGMVDPSLNPISAFRLSVIQNSAVWAILNEIHIKK 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9384	NP_001261847.1	Glyco_transf_54	129..412	CDD:282514	138/282 (49%)
MGAT4A	NP_036346.1	Glyco_transf_54	103..380	CDD:398374	138/282 (49%)
MGAT4A	NP_036346.1	putative TM2 helix	287..311	CDD:409189	12/23 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148142
Domainoid	1	1.000	307	1.000	Domainoid score	I1354
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	421	1.000	Inparanoid score	I1789
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48935
OrthoDB	1	1.010	-	-		D268757at33208
OrthoFinder	1	1.000	-	-		FOG0002296
OrthoInspector	1	1.000	-	-		otm40881
orthoMCL	1	0.900	-	-		OOG6_104024
Panther	1	1.100	-	-	O	PTHR12062
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5668
SonicParanoid	1	1.000	-	-		X1731
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.900