Protein Alignment Mgat4a and MGAT4B

DIOPT Version :10

• Sequence 1: NP_648720.3
• Gene: Mgat4a / 39608
• FlyBaseID: FBgn0036446
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: NP_463459.1
• Gene: MGAT4B / 11282
• HGNCID: 7048
• Length: 563
• Species: Homo sapiens
• Alignment Length: 458
• Identity: 211/458 - (46%)
• Similarity: 296/458 - (64%)
• Gaps: 24/458 - (5%)

  Fly   120 NGSMARSQNIRLPNAYHFLPHLLDDAGSLRPAYLQSKGRSDVSIVLGVPTVRREKQSYLLGTLHN 184
            |||  ....:.||..:|.|||||....||:||....:||:.||:|:|:|:||||..|||..|||:
Human   118 NGS--HRHVLHLPTVFHHLPHLLAKESSLQPAVRVGQGRTGVSVVMGIPSVRREVHSYLTDTLHS 180

  Fly   185 LIENMNDEEQNETLIIVYIGETDMESVQLIARQIESSFDQHVESGLIDIIAPAPSYYPNFERLRI 249
            ||..::.:|:.:::|:|.|.|||.:....:...|::.|...:.|||:::|:|:|.:||:|.|||.
Human   181 LISELSPQEKEDSVIVVLIAETDSQYTSAVTENIKALFPTEIHSGLLEVISPSPHFYPDFSRLRE 245

  Fly   250 TLNDPLERVKWRSKQNLDFAYLMAYAHSKGTFYVQLEDDILTKRQFITTMKKFALIKSALTKPDQ 314
            :..||.|||:||:|||||:.:||.||.|||.:||||||||:.|..:::|||.|||        .|
Human   246 SFGDPKERVRWRTKQNLDYCFLMMYAQSKGIYYVQLEDDIVAKPNYLSTMKNFAL--------QQ 302

  Fly   315 P--EWFVLDFCQLGFIGKMFKSAELPYLITYFQMFYNDKPVDWLLTYFIESKVCRTDKDQKHCNA 377
            |  :|.:|:|.|||||||||||.:|..::.:..|||.|||:||||.:.:..|||..:||.|||:.
Human   303 PSEDWMILEFSQLGFIGKMFKSLDLSLIVEFILMFYRDKPIDWLLDHILWVKVCNPEKDAKHCDR 367

  Fly   378 EKAKYWQHFRKSLFQHIGTSSSLKGKVQKLKDKQFGSKVPQYYAHTH-NPPALVKSNIAPYKNYL 441
            :||.....|:.|||||:||.|||.||:||||||.||.   |.....| ||||.|.:::..|:::.
Human   368 QKANLRIRFKPSLFQHVGTHSSLAGKIQKLKDKDFGK---QALRKEHVNPPAEVSTSLKTYQHFT 429

  Fly   442 LQRAYRGESYFWGLLPQPGDLVQIIFERPTQLRHYLFRSGNSEHPSDRFYNTTVELLPAD----- 501
            |::||..|.:||...|..||.::..|.:|.:|..:.|||||.|||.|:.:||:||:||.|
Human   430 LEKAYLREDFFWAFTPAAGDFIRFRFFQPLRLERFFFRSGNIEHPEDKLFNTSVEVLPFDNPQSD 494

  Fly   502 --TLSENSSVWSSYNTTTDGYLVVGSFDSMGVAEGLLDAKIGAIKELRLHVHSDSENWALLSEIE 564
              .|.|..:....|..:.||||.:||| ..|||||.:|...|.::.|||.:.:||..|.:||||.
Human   495 KEALQEGRTATLRYPRSPDGYLQIGSF-YKGVAEGEVDPAFGPLEALRLSIQTDSPVWVILSEIF 558

  Fly   565 LQE 567
            |::
Human   559 LKK 561

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mgat4a	NP_648720.3	Glyco_transf_54	129..412	CDD:461384	142/284 (50%)
MGAT4B	NP_463459.1	Glyco_transf_54	125..402	CDD:461384	142/284 (50%)
		putative TM2 helix	309..329	CDD:409189	14/19 (74%)