DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13473 and ERP44

DIOPT Version :9

Sequence 1:	NP_648717.1	Gene:	CG13473 / 39603	FlyBaseID:	FBgn0036442	Length:	139	Species:	Drosophila melanogaster
Sequence 2:	NP_055866.1	Gene:	ERP44 / 23071	HGNCID:	18311	Length:	406	Species:	Homo sapiens

Alignment Length:	125	Identity:	28/125 - (22%)
Similarity:	64/125 - (51%)	Gaps:	20/125 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KVIIVDSKSYFDKLIDDAGTNKYVLVEFFATWCGPCAMIGPRLEQLASDYF-------GRMLVLK 64
            ::..:|::: .|:::::|..   .||.|:|.||....|:.|..|: |||..       .:::..:
Human    30 EITSLDTEN-IDEILNNADV---ALVNFYADWCRFSQMLHPIFEE-ASDVIKEEFPNENQVVFAR 89

  Fly    65 IDVDENEDLAVQYEVNSMPTFLIIKNRVTLIQFVGGNVERVVSTVEKFVGKVEDSKEHKS 124
            :|.|::.|:|.:|.::..||..:.:|.:.:.:...|  :|.|..:..::      ::.||
Human    90 VDCDQHSDIAQRYRISKYPTLKLFRNGMMMKREYRG--QRSVKALADYI------RQQKS 141

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13473	NP_648717.1	Thioredoxin	8..111	CDD:278513	26/109 (24%)
ERP44	NP_055866.1	PDI_a_ERp44	29..136	CDD:239294	26/112 (23%)
		PDI_b_ERp44	144..234	CDD:239368
		Interaction with ITPR1. /evidence=ECO:0000250	236..285
		PDI_b'_ERp44	245..355	CDD:239370
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	360..387
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	403..406
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910