DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4914 and TMPRSS5

DIOPT Version :9

Sequence 1:	NP_648711.1	Gene:	CG4914 / 39597	FlyBaseID:	FBgn0036436	Length:	374	Species:	Drosophila melanogaster
Sequence 2:	NP_110397.2	Gene:	TMPRSS5 / 80975	HGNCID:	14908	Length:	457	Species:	Homo sapiens

Alignment Length:	413	Identity:	131/413 - (31%)
Similarity:	184/413 - (44%)	Gaps:	79/413 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 WPLVLAMA------------------SCLLFTAATSATPATPATPATSAPPATSTATSSLSSIP- 54
            |.|||.:.                  ||...:|..:..||.|.|.:...........:.:...|
Human    66 WLLVLYLCPAASQPISGTLQDEEITLSCSEASAEEALLPALPKTVSFRINSEDFLLEAQVRDQPR 130

  Fly    55 -------GKYQALG-----------AAHHQAKKLKIGDVNASSSDANKPVFRQNPIKNWFGAF-- 99
                   |...|||           ..||  |.:.:.|:..:||..    |.|  :....|.|
Human   131 WLLVCHEGWSPALGLQICWSLGHLRLTHH--KGVNLTDIKLNSSQE----FAQ--LSPRLGGFLE 187

  Fly   100 ----NRNNSPAAQNQTSPTCSCRCGERNDESRIVGGTTTGVSEYPWMARLSYFNRFYCGGTLIND 160
                .|||..:.| ..|..|| .||.|...||||||.:.....:||.|.::...|..|||:::..
Human   188 EAWQPRNNCTSGQ-VVSLRCS-ECGARPLASRIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAP 250

  Fly   161 RYVLTAAHCVKGF------MWFMIKVTFG--EHDRCNDKERP-ETRFVLRAFSQK-FSFSNFDND 215
            |:|:|||||:..|      .|   :|..|  .|...    || :...|.|..... :|..|.|.|
Human   251 RWVVTAAHCMHSFRLARLSSW---RVHAGLVSHSAV----RPHQGALVERIIPHPLYSAQNHDYD 308

  Fly   216 IALLRLNDRVPITSFIRPICLPRVEQRQDLFVGTKAIATGWG-TLKEDGKPSCLLQEVEVPVLDN 279
            :|||||...:..:..:..:|||..||.  ...|::...:||| |.......|.:||:..||:...
Human   309 VALLRLQTALNFSDTVGAVCLPAKEQH--FPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFST 371

  Fly   280 DECVAQTNYTQKMITKNMMCSGYPGVGGR-DSCQGDSGGPLVRLRPDDKRFEQIGIVSWGNGCAR 343
            ..|.:...|: ..:|..|:|:||  :.|| |:||||||||||  .||...:..:|:||||.|||.
Human   372 QLCNSSCVYS-GALTPRMLCAGY--LDGRADACQGDSGGPLV--CPDGDTWRLVGVVSWGRGCAE 431

  Fly   344 PNYPGVYTRVTKYLDWIVENSRD 366
            ||:||||.:|.::||||.:.::|
Human   432 PNHPGVYAKVAEFLDWIHDTAQD 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4914	NP_648711.1	Tryp_SPc	127..360	CDD:214473	91/244 (37%)
CG4914	NP_648711.1	Tryp_SPc	128..363	CDD:238113	92/246 (37%)
TMPRSS5	NP_110397.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		SRCR_2	116..213	CDD:292133	24/106 (23%)
		Tryp_SPc	217..448	CDD:214473	91/244 (37%)
		Tryp_SPc	218..451	CDD:238113	92/246 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	175	1.000	Inparanoid score	I4057
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960