DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4914 and TMPRSS2

DIOPT Version :9

Sequence 1:	NP_648711.1	Gene:	CG4914 / 39597	FlyBaseID:	FBgn0036436	Length:	374	Species:	Drosophila melanogaster
Sequence 2:	NP_001128571.1	Gene:	TMPRSS2 / 7113	HGNCID:	11876	Length:	529	Species:	Homo sapiens

Alignment Length:	300	Identity:	95/300 - (31%)
Similarity:	140/300 - (46%)	Gaps:	69/300 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 NSPAAQNQTSPTCSC-RCG---ERNDESRIVGGTTTGVSEYPWMARLSYFNRFYCGGTLINDRYV 163
            :|.|..::...:..| .||   ..:.:||||||.:.....:||...|...|...|||::|...::
Human   264 HSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWI 328

  Fly   164 LTAAHCVKGFMWFMIKVTFGEHDRCNDKERP------ETRF--VLRAFSQKFSF----------- 209
            :||||||                     |:|      .|.|  :||   |.|.|
Human   329 VTAAHCV---------------------EKPLNNPWHWTAFAGILR---QSFMFYGAGYQVEKVI 369

  Fly   210 --SNFD-----NDIALLRLNDRVPITSFIRPICLPR----VEQRQDLFVGTKAIATGWGTLKEDG 263
              .|:|     |||||::|...:.....::|:|||.    ::..|..::      :|||..:|.|
Human   370 SHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWI------SGWGATEEKG 428

  Fly   264 KPSCLLQEVEVPVLDNDECVAQTNYTQKMITKNMMCSGYPGVGGRDSCQGDSGGPLVRLRPDDKR 328
            |.|.:|...:|.:::...|.::..| ..:||..|:|:|:. .|..||||||||||||..:  :..
Human   429 KTSEVLNAAKVLLIETQRCNSRYVY-DNLITPAMICAGFL-QGNVDSCQGDSGGPLVTSK--NNI 489

  Fly   329 FEQIGIVSWGNGCARPNYPGVYTRVTKYLDWIVENSR-DG 367
            :..||..|||:|||:...||||..|..:.|||....| ||
Human   490 WWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRADG 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4914	NP_648711.1	Tryp_SPc	127..360	CDD:214473	84/262 (32%)
CG4914	NP_648711.1	Tryp_SPc	128..363	CDD:238113	85/264 (32%)
TMPRSS2	NP_001128571.1	DUF3824	<44..91	CDD:289625
		LDLa	150..185	CDD:238060
		SRCR_2	190..283	CDD:292133	4/18 (22%)
		Tryp_SPc	292..521	CDD:214473	84/262 (32%)
		Tryp_SPc	293..524	CDD:238113	85/264 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	175	1.000	Inparanoid score	I4057
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8579
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.960