DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4914 and C1s1

DIOPT Version :9

Sequence 1:	NP_648711.1	Gene:	CG4914 / 39597	FlyBaseID:	FBgn0036436	Length:	374	Species:	Drosophila melanogaster
Sequence 2:	NP_001091086.1	Gene:	C1s1 / 50908	MGIID:	1355312	Length:	694	Species:	Mus musculus

Alignment Length:	290	Identity:	95/290 - (32%)
Similarity:	134/290 - (46%)	Gaps:	63/290 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 PTCSCRCGERND----ESRIVGGTTTGVSEYPWMARLSYFNRFYCGGTLINDRYVLTAAHCVK-- 171
            |.|...||...:    ..||.||....:..:||..   :||.....|.|||:.:||||||.::
Mouse   425 PRCIPACGVPTEPFQVHQRIFGGQPAKIENFPWQV---FFNHPRASGALINEYWVLTAAHVLEKI 486

  Fly   172 -------GFMWFMIKVTFGE------------HDRCNDKERPETRFVLRAFSQKFSFSNFDNDIA 217
                   |.|  .::.|..|            |.....::.|.||            :|||||||
Mouse   487 SDPLMYVGTM--SVRTTLLENAQRLYSKRVFIHPSWKKEDDPNTR------------TNFDNDIA 537

  Fly   218 LLRLNDRVPITSFIRPICLPRVEQRQDLFVGTKAIATGWGTLKEDGKPSCL-LQEVEVPVLDNDE 281
            |::|.|.|.:...:.|||||......::..|...:.:|||:.::  |...: |:..:|||...:.
Mouse   538 LVQLKDPVKMGPKVSPICLPGTSSEYNVSPGDMGLISGWGSTEK--KVFVINLRGAKVPVTSLET 600

  Fly   282 C--VAQTNYTQK----MITKNMMCSGYPGVGGRDSCQGDSGGPLVRLRPD--DKRFEQIGIVSWG 338
            |  |.:.|.|.:    :.|.||:|:|..||   |||.|||||......|:  ..:|...|:||||
Mouse   601 CKQVKEENPTVRPEDYVFTDNMICAGEKGV---DSCHGDSGGAFAFQVPNVTVPKFYVAGLVSWG 662

  Fly   339 NGCARPNYPGVYTRVTKYLDWIV----ENS 364
            ..|.  .| ||||:|..|:|||:    |||
Mouse   663 KRCG--TY-GVYTKVKNYVDWILKTMQENS 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4914	NP_648711.1	Tryp_SPc	127..360	CDD:214473	86/262 (33%)
CG4914	NP_648711.1	Tryp_SPc	128..363	CDD:238113	87/268 (32%)
C1s1	NP_001091086.1	CUB	24..135	CDD:238001
		FXa_inhibition	149..177	CDD:373209
		CUB	181..293	CDD:366096
		CCP	307..361	CDD:153056
		CCP	365..428	CDD:153056	1/2 (50%)
		Tryp_SPc	443..681	CDD:214473	86/262 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7195
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.860