DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4914 and KLKB1

DIOPT Version :9

Sequence 1:	NP_648711.1	Gene:	CG4914 / 39597	FlyBaseID:	FBgn0036436	Length:	374	Species:	Drosophila melanogaster
Sequence 2:	XP_011530232.1	Gene:	KLKB1 / 3818	HGNCID:	6371	Length:	649	Species:	Homo sapiens

Alignment Length:	408	Identity:	128/408 - (31%)
Similarity:	183/408 - (44%)	Gaps:	73/408 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 WPLVLAMASCLLFTAATSATPATPATPATSAPPATSTATSSL----SSIPGK-----YQALGAAH 64
            |.:......|||.|:.:       .||::|.|...:.:..||    .::|..     |..:....
Human   258 WKIESQRNVCLLKTSES-------GTPSSSTPQENTISGYSLLTCKRTLPEPCHSKIYPGVDFGG 315

  Fly    65 HQAKKLKIGDVNASSSDANKPV-------------FRQNPIKNWFGAFNRNNSP---AAQNQTSP 113
            .:.....:..||.......|.:             .::...| .|...:.:.||   |...|.|.
Human   316 EELNVTFVKGVNVCQETCTKMIRCQFFTYSLLPEDCKEEKCK-CFLRLSMDGSPTRIAYGTQGSS 379

  Fly   114 TCSCRCGERNDES--------RIVGGTTTGVSEYPWMARLSY---FNRFYCGGTLINDRYVLTAA 167
            ..|.|.....|.|        ||||||.:...|:||...|..   ..|..|||:||..::|||||
Human   380 GYSLRLCNTGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAA 444

  Fly   168 HCVKGF----MWFMIKVTFGEHDRCNDKERPETRFVLRAFSQKFSFSNFDNDIALLRLNDRVPIT 228
            ||..|.    :|.:........|...|....:.:.::  ..|.:..|..::||||::|...:..|
Human   445 HCFDGLPLQDVWRIYSGILNLSDITKDTPFSQIKEII--IHQNYKVSEGNHDIALIKLQAPLNYT 507

  Fly   229 SFIRPICLPRVEQRQDLFVGTKAIATGWGTLKEDGKPSCLLQEVEVPVLDNDECVAQTNYTQKMI 293
            .|.:|||||.......::  |....||||..||.|:...:||:|.:|::.|:||  |..|....|
Human   508 EFQKPICLPSKGDTSTIY--TNCWVTGWGFSKEKGEIQNILQKVNIPLVTNEEC--QKRYQDYKI 568

  Fly   294 TKNMMCSGYPGVGGRDSCQGDSGGPLV-------RLRPDDKRFEQIGIVSWGNGCARPNYPGVYT 351
            |:.|:|:||. .||:|:|:||||||||       ||         :||.|||.||||...|||||
Human   569 TQRMVCAGYK-EGGKDACKGDSGGPLVCKHNGMWRL---------VGITSWGEGCARREQPGVYT 623

  Fly   352 RVTKYLDWIVE--NSRDG 367
            :|.:|:|||:|  .|.||
Human   624 KVAEYMDWILEKTQSSDG 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4914	NP_648711.1	Tryp_SPc	127..360	CDD:214473	95/246 (39%)
CG4914	NP_648711.1	Tryp_SPc	128..363	CDD:238113	97/250 (39%)
KLKB1	XP_011530232.1	APPLE	21..104	CDD:128519
		APPLE	111..194	CDD:128519
		APPLE	212..295	CDD:128519	11/43 (26%)
		APPLE	303..386	CDD:128519	13/83 (16%)
		Tryp_SPc	401..632	CDD:214473	95/246 (39%)
		Tryp_SPc	402..632	CDD:238113	94/245 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42230
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910