DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4914 and f2

DIOPT Version :9

Sequence 1:	NP_648711.1	Gene:	CG4914 / 39597	FlyBaseID:	FBgn0036436	Length:	374	Species:	Drosophila melanogaster
Sequence 2:	XP_005169022.1	Gene:	f2 / 325881	ZFINID:	ZDB-GENE-030131-4606	Length:	635	Species:	Danio rerio

Alignment Length:	295	Identity:	110/295 - (37%)
Similarity:	149/295 - (50%)	Gaps:	54/295 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 CGER-----------NDE--------SRIVGGTTTGVSEYPWMARLSYFNR----FYCGGTLIND 160
            ||||           |::        ||||||....|:..||...|  :.|    ..||.:||:|
Zfish   346 CGERPLFEKINKADKNEKELLMSYTGSRIVGGDEAEVASAPWQVML--YKRSPQELLCGASLISD 408

  Fly   161 RYVLTAAHCV------KGFMWFMIKVTFGEHDRCNDKERPETRFVLRAFSQ-----KFSF-SNFD 213
            .::||||||:      |.|....|.|..|:|.| ...||...:.|  |..:     |::: .|.:
Zfish   409 EWILTAAHCILYPPWNKNFTINDIIVRLGKHSR-TKYERGIEKIV--AIDEIIVHPKYNWKENLN 470

  Fly   214 NDIALLRLNDRVPITSFIRPICLPRVEQRQDL-FVGTKAIATGWGTLKED--GKPSCL---LQEV 272
            .|||||.:...|..||.|.|:|||.....::| |.|.|...||||.|:|.  ..|:.|   ||::
Zfish   471 RDIALLHMKKPVVFTSEIHPVCLPTKSIAKNLMFAGYKGRVTGWGNLRESWTSNPTNLPTVLQQI 535

  Fly   273 EVPVLDNDECVAQTNYTQKMITKNMMCSGY-PGVGGR-DSCQGDSGGPLVRLRPDDKRFEQIGIV 335
            .:|::|...|   .|.|..:||.||.|:|| |....| |:|:||||||.|...|.|.|:.|||||
Zfish   536 HLPIVDQSIC---RNSTSVIITDNMFCAGYQPDDSKRGDACEGDSGGPFVMKSPSDNRWYQIGIV 597

  Fly   336 SWGNGCARPNYPGVYT---RVTKYLDWIVENSRDG 367
            |||.||.|....|.||   |:.:::..::|.:..|
Zfish   598 SWGEGCDRDGKYGFYTHLFRMRRWMKKVIEKTDSG 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4914	NP_648711.1	Tryp_SPc	127..360	CDD:214473	102/259 (39%)
CG4914	NP_648711.1	Tryp_SPc	128..363	CDD:238113	101/261 (39%)
f2	XP_005169022.1	GLA	39..100	CDD:214503
		KR	126..206	CDD:214527
		KR	228..309	CDD:214527
		Thrombin_light	326..373	CDD:286482	5/26 (19%)
		Tryp_SPc	373..621	CDD:214473	102/255 (40%)
		Tryp_SPc	374..625	CDD:238113	101/258 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910