DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4914 and F2

DIOPT Version :9

Sequence 1:	NP_648711.1	Gene:	CG4914 / 39597	FlyBaseID:	FBgn0036436	Length:	374	Species:	Drosophila melanogaster
Sequence 2:	NP_075213.2	Gene:	F2 / 29251	RGDID:	61996	Length:	617	Species:	Rattus norvegicus

Alignment Length:	259	Identity:	94/259 - (36%)
Similarity:	130/259 - (50%)	Gaps:	29/259 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 ESRIVGGTTTGVSEYPWMARLSYFNR----FYCGGTLINDRYVLTAAHCV------KGFMWFMIK 179
            :.|||.|........||...|  |.:    ..||.:||:||:|||||||:      |.|....:.
  Rat   357 DGRIVEGWDAEKGIAPWQVML--FRKSPQELLCGASLISDRWVLTAAHCILYPPWDKNFTENDLL 419

  Fly   180 VTFGEHDRCNDKERPETRFVLRA--FSQKFSF-SNFDNDIALLRLNDRVPITSFIRPICLPRVEQ 241
            |..|:|.|...:...|...:|..  ...:::: .|.|.|||||:|...||.:.:|.|:|||..:.
  Rat   420 VRIGKHSRTRYERNVEKISMLEKIYIHPRYNWRENLDRDIALLKLKKPVPFSDYIHPVCLPDKQT 484

  Fly   242 RQDLF-VGTKAIATGWGTLKE-------DGKPSCLLQEVEVPVLDNDECVAQTNYTQKMITKNMM 298
            ...|. .|.|...||||.|:|       :.:|| :||.|.:|:::...|.|.|..   .||.||.
  Rat   485 VTSLLQAGYKGRVTGWGNLRETWTTNINEIQPS-VLQVVNLPIVERPVCKASTRI---RITDNMF 545

  Fly   299 CSGYP--GVGGRDSCQGDSGGPLVRLRPDDKRFEQIGIVSWGNGCARPNYPGVYTRVTKYLDWI 360
            |:|:.  .....|:|:||||||.|...|.:.|:.|:||||||.||.|....|.||.|.:...|:
  Rat   546 CAGFKVNDTKRGDACEGDSGGPFVMKSPYNHRWYQMGIVSWGEGCDRNGKYGFYTHVFRLKRWM 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4914	NP_648711.1	Tryp_SPc	127..360	CDD:214473	93/255 (36%)
CG4914	NP_648711.1	Tryp_SPc	128..363	CDD:238113	93/256 (36%)
F2	NP_075213.2	GLA	25..89	CDD:214503
		KR	107..189	CDD:214527
		Kringle	215..292	CDD:278480
		Thrombin_light	312..359	CDD:286482	0/1 (0%)
		Tryp_SPc	359..608	CDD:214473	93/254 (37%)
		Tryp_SPc	360..612	CDD:238113	93/256 (36%)
		High affinity receptor-binding region which is also known as the TP508 peptide	547..569		9/21 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910