DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4914 and PRSS55

DIOPT Version :9

Sequence 1:	NP_648711.1	Gene:	CG4914 / 39597	FlyBaseID:	FBgn0036436	Length:	374	Species:	Drosophila melanogaster
Sequence 2:	NP_940866.2	Gene:	PRSS55 / 203074	HGNCID:	30824	Length:	352	Species:	Homo sapiens

Alignment Length:	362	Identity:	103/362 - (28%)
Similarity:	151/362 - (41%)	Gaps:	81/362 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LAMASCLLFTAATSATPATPATPATSAPPATSTATSSLSSIPGKYQALGAAHHQAKKLKIGDVNA 77
            :.:.|.||..:..:.|...|.||...|..|                .||.|.
Human     1 MLLFSVLLLLSLVTGTQLGPRTPLPEAGVA----------------ILGRAR------------- 36

  Fly    78 SSSDANKPVFRQNPIKNWFGAFNRNNSPAAQNQTSPTCSCRCGERN------DESRIVGGTTTGV 136
               .|::|.....|            ||.::          ||:|:      ..|||.||....|
Human    37 ---GAHRPQPPHPP------------SPVSE----------CGDRSIFEGRTRYSRITGGMEAEV 76

  Fly   137 SEYPWMARLSYFNRFYCGGTLINDRYVLTAAHCVKGFMWF--MIKVTFGEHDRCN-DKERPETRF 198
            .|:||...:...:..:|||:::|..::||||||:.....|  .:.|..|.:|..: ..|..|...
Human    77 GEFPWQVSIQARSEPFCGGSILNKWWILTAAHCLYSEELFPEELSVVLGTNDLTSPSMEIKEVAS 141

  Fly   199 VLRAFSQKFSFSNFDNDIALLRLNDRVPITSFIRPICLPRVEQRQDLFVGTKAIATGWGTLKEDG 263
            ::  ..:.|..:|.|||||||.|...:.:.....|||||   .:.......:....|||......
Human   142 II--LHKDFKRANMDNDIALLLLASPIKLDDLKVPICLP---TQPGPATWRECWVAGWGQTNAAD 201

  Fly   264 KPSCLLQEVEVP--VLDNDECVAQTNYTQKM---ITKNMMCSGYPGVGGRDSCQGDSGGPLVRLR 323
            |.|.....::.|  ::|.:||       .||   :||||:|:||.. ...|:|:||||||||...
Human   202 KNSVKTDLMKAPMVIMDWEEC-------SKMFPKLTKNMLCAGYKN-ESYDACKGDSGGPLVCTP 258

  Fly   324 PDDKRFEQIGIVSWGNGCARPNYPGVYTRVTKYLDWI 360
            ...:::.|:||:|||..|...|.||:||.:..|..||
Human   259 EPGEKWYQVGIISWGKSCGEKNTPGIYTSLVNYNLWI 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4914	NP_648711.1	Tryp_SPc	127..360	CDD:214473	80/240 (33%)
CG4914	NP_648711.1	Tryp_SPc	128..363	CDD:238113	81/241 (34%)
PRSS55	NP_940866.2	Tryp_SPc	67..295	CDD:214473	80/240 (33%)
		Tryp_SPc	68..298	CDD:238113	81/241 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	308..330
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BMSX
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810