DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4914 and tmprss2.2

DIOPT Version :9

Sequence 1:	NP_648711.1	Gene:	CG4914 / 39597	FlyBaseID:	FBgn0036436	Length:	374	Species:	Drosophila melanogaster
Sequence 2:	XP_002941330.2	Gene:	tmprss2.2 / 100493729	XenbaseID:	XB-GENE-22065949	Length:	521	Species:	Xenopus tropicalis

Alignment Length:	339	Identity:	104/339 - (30%)
Similarity:	146/339 - (43%)	Gaps:	98/339 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 NW-----------FG----AFNRNN---SPAAQN------------------QTSPTC------- 115
            ||           ||    ::||:|   ||.|.|                  |.|.:|
Frog   201 NWSDAYGRFACRDFGYSGSSYNRSNTLPSPYAPNGYFKLNNGFGSSQFYTSVQNSSSCFSGNVVS 265

  Fly   116 ----SCRCGERNDESRIVGGTTTGVSEYPWMARLSYFNRFYCGGTLINDRYVLTAAHCVKGFMWF 176
                ||.....:..|||||||......:.|...|.|.....|||::|:.::::||||||.|...|
Frog   266 LRCISCGVSYNSVASRIVGGTYAAYGNWLWQVGLRYNTGILCGGSIISPKWIVTAAHCVYGTDGF 330

  Fly   177 MIKVTFGEHDRCNDKERPETRFVLRAFSQKFSFSNF----------------------DNDIALL 219
            ::..:                 ..|.|:...:..::                      ||||||:
Frog   331 LLSAS-----------------GWRVFAGTLTLPSYYDSSGYLVERIIPHPGYKTSSNDNDIALM 378

  Fly   220 RLNDRVPITSFIRPICLPRVEQRQDLF--VGTKAIATGWGTLKEDGKPSCLLQEVEVPVLDNDEC 282
            .|::.:......:|:|||..    .:|  .||....:||||..:.|..|..||...|.::|::.|
Frog   379 ELSNGITFGYNTQPVCLPNA----GMFWSSGTPCWISGWGTTSQGGSASTYLQYAAVQLIDSNVC 439

  Fly   283 VAQTNYTQK-MITKNMMCSGYPGVGGRDSCQGDSGGPLVRLRPDDKRFEQIGIVSWGNGCARPNY 346
              ..||... .||.:|:|:||.. ||.||||||||||||  ...:..:..:|..|||.|||:||.
Frog   440 --NQNYVYNGQITASMICAGYLS-GGVDSCQGDSGGPLV--TKTNGTWWLVGDTSWGYGCAQPNK 499

  Fly   347 PGVYTRVTKYLDWI 360
            ||||..:|.:|.||
Frog   500 PGVYGNMTSFLGWI 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4914	NP_648711.1	Tryp_SPc	127..360	CDD:214473	85/257 (33%)
CG4914	NP_648711.1	Tryp_SPc	128..363	CDD:238113	86/258 (33%)
tmprss2.2	XP_002941330.2	LDLa	<111..134	CDD:238060
		LDLa	145..174	CDD:238060
		SRCR_2	179..274	CDD:292133	16/72 (22%)
		Tryp_SPc	281..513	CDD:214473	85/257 (33%)
		Tryp_SPc	282..513	CDD:238113	84/256 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000