Protein Alignment dlp and GPC1

DIOPT Version :9

• Sequence 1: NP_524071.2
• Gene: dlp / 39596
• FlyBaseID: FBgn0041604
• Length: 765
• Species: Drosophila melanogaster
• Sequence 2: NP_002072.2
• Gene: GPC1 / 2817
• HGNCID: 4449
• Length: 558
• Species: Homo sapiens
• Alignment Length: 590
• Identity: 164/590 - (27%)
• Similarity: 270/590 - (45%)
• Gaps: 111/590 - (18%)

  Fly    52 APQVAALAAPNPAGGVAGSSIIDQFSPNCSAVTHIFQARGIDAIEIPQKPSNERVLRYCESPSVG 116
            |..:.|.|..:||..          |.:|..|..|:.|:|....::||...:...||.|  |...
Human    14 AAALVACARGDPASK----------SRSCGEVRQIYGAKGFSLSDVPQAEISGEHLRIC--PQGY 66

  Fly   117 TCCTYNMETRMAMQSRQQLEGHTKDQISRMSGILGSKATKFKDIFTALLKESRTQFNSMFIRTYG 181
            ||||..||..:|.:|..:||...:|....:..:|.::...|.|.|..||.:|.....:.|...:|
Human    67 TCCTSEMEENLANRSHAELETALRDSSRVLQAMLATQLRSFDDHFQHLLNDSERTLQATFPGAFG 131

  Fly   182 VIYERNSYVFSDLFKELETYFANGRVDLLEVMDKFFNTLYQKMFTVLNTQYTFDENYMRCVSEHM 246
            .:|.:|:..|.||:.||..|:....:.|.|.:.:|:..|.:::|..|:.|....::|:.|:.:..
Human   132 ELYTQNARAFRDLYSELRLYYRGANLHLEETLAEFWARLLERLFKQLHPQLLLPDDYLDCLGKQA 196

  Fly   247 KELKPFGDVPDKLSVQIKRSFVATRTYGQALTTASEVAKKVLNVRLNADCTGALTKMQHCGACKG 311
            :.|:|||:.|.:|.::..|:|||.|::.|.|..||:|.:||..|.|..:|:.|:.|:.:|..|.|
Human   197 EALRPFGEAPRELRLRATRAFVAARSFVQGLGVASDVVRKVAQVPLGPECSRAVMKLVYCAHCLG 261

  Fly   312 YT-EKPCTNYCVNVIKGCLHYQHEFDSEWENFAMAMDKVAERLLGSFNIVMVVEPLNIKISEAIM 375
            .. .:||.:||.||:||||..|.:.|:||.|...:|..:.::..|:..:..|:..::..::|||.
Human   262 VPGARPCPDYCRNVLKGCLANQADLDAEWRNLLDSMVLITDKFWGTSGVESVIGSVHTWLAEAIN 326

  Fly   376 NFQDSGQDITNRVFQGCGRPKLKKMKRSISPKLQGVQILNARSPVEADTLDIDETLDEAIVLRER 440
            ..||:...:|.:|.||||.||       ::|  ||
Human   327 ALQDNRDTLTAKVIQGCGNPK-------VNP--QG------------------------------ 352

  Fly   441 RAAEPGSQETSAQQSQEQGVGKSGNGGGGGGGNNRRQQQRRKQQQQRRKQQNNRDDNDDDDNESG 505
                ||.:|                            ::||.:...|.:..:.
Human   353 ----PGPEE----------------------------KRRRGKLAPRERPPSG------------ 373

  Fly   506 GGREPILDRIVRDIRQRVKDYKKFWSNLPHSVCSNEDIASSSDVDGMCWNGHTIDRYMHSI---- 566
                 .|:::|.:.:.:::|.:.||.:||.::|| |.:|.|:..|..||||....||:..:
Human   374 -----TLEKLVSEAKAQLRDVQDFWISLPGTLCS-EKMALSTASDDRCWNGMARGRYLPEVMGDG 432

  Fly   567 TTEHGSNPEFTGNPASTKQTAQMASQLSHLKNAIVHLRNAYNGQDVEWSEQEELPYAGSGAGSGS 631
            .....:|||...:  .||....:..|:..||.....||:||||.||::.:..:   .|||:|||.
Human   433 LANQINNPEVEVD--ITKPDMTIRQQIMQLKIMTNRLRSAYNGNDVDFQDASD---DGSGSGSGD 492

  Fly   632 GSEDD 636
            |..||
Human   493 GCLDD 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dlp	NP_524071.2	Glypican	79..613	CDD:279494	148/538 (28%)
GPC1	NP_002072.2	Glypican	22..533	CDD:366494	161/582 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	341..374		15/120 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	505..534

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147851
Domainoid	1	1.000	286	1.000	Domainoid score	I1604
eggNOG	1	0.900	-	-		E1_KOG3821
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	373	1.000	Inparanoid score	I2117
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46379
OrthoDB	1	1.010	-	-		D275653at33208
OrthoFinder	1	1.000	-	-		FOG0000903
OrthoInspector	1	1.000	-	-		otm41759
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10822
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3318
SonicParanoid	1	1.000	-	-		X519
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.900