Protein Alignment dlp and GPC3

DIOPT Version :9

• Sequence 1: NP_524071.2
• Gene: dlp / 39596
• FlyBaseID: FBgn0041604
• Length: 765
• Species: Drosophila melanogaster
• Sequence 2: NP_001158089.1
• Gene: GPC3 / 2719
• HGNCID: 4451
• Length: 603
• Species: Homo sapiens
• Alignment Length: 678
• Identity: 142/678 - (20%)
• Similarity: 261/678 - (38%)
• Gaps: 128/678 - (18%)

  Fly    17 ATATTTARLVIFSSPLLLLLLTTHLPPTLQADNGPAPQVAALAAPNPAGGVAGSSIIDQFSPNCS 81
            |....||.||:      .:||:...|.  ||...|.|..|                      .|.
Human     2 AGTVRTACLVV------AMLLSLDFPG--QAQPPPPPPDA----------------------TCH 36

  Fly    82 AVTHIFQARGIDAIEIPQKPSNERVLRYCESPSVGTCCTYNMETRMAMQSRQQLEGHTKDQISRM 146
            .|...||........:|:.|.....|:.| .|...|||:..||.:..:.:|..:|...:.....:
Human    37 QVRSFFQRLQPGLKWVPETPVPGSDLQVC-LPKGPTCCSRKMEEKYQLTARLNMEQLLQSASMEL 100

  Fly   147 SGILGSKATKFKDIFTALLKESRTQFNSMFIRTYGVIYERNSYVFSDLFKELETYFANGRVDLLE 211
            ..::...|..|::.|..:::.::...|:||...|..:..:......:.|.::..|.....::
Human   101 KFLIIQNAAVFQEAFEIVVRHAKNYTNAMFKNNYPSLTPQAFEFVGEFFTDVSLYILGSDIN--- 162

  Fly   212 VMDKFFNTLYQKMFTVLNTQY--------TFDENYMRCVSEHMKELKPFGDVPDKLSVQIKRSFV 268
             :|...|.|:..:|.|:.||.        ..|.|  .|:....::||.||:.|..:..|:.:|..
Human   163 -VDDMVNELFDSLFPVIYTQLMNPGLPDSALDIN--ECLRGARRDLKVFGNFPKLIMTQVSKSLQ 224

  Fly   269 ATRTYGQALTTASEVAKKVLNVRLNADCTGALTKMQHCGACKG-YTEKPCTNYCVNVIKGCLHYQ 332
            .||.:.|||....||.....:::.:.||...||:|.:|..|:| ...|||..||..|::||:...
Human   225 VTRIFLQALNLGIEVINTTDHLKFSKDCGRMLTRMWYCSYCQGLMMVKPCGGYCNVVMQGCMAGV 289

  Fly   333 HEFDSEWENFAMAMDKVAERLLGSFNIVMVVEPLNIKISEAIMNFQDSGQDITNRVFQGCGRPKL 397
            .|.|..|..:.::::::...:...:::..|:..|...|.::|...|.:...:|....:
Human   290 VEIDKYWREYILSLEELVNGMYRIYDMENVLLGLFSTIHDSIQYVQKNAGKLTTTETE------- 347

  Fly   398 KKMKRSISPKLQGVQILNARSPVEADTLDIDETLDEAIVLRERRAAEPGSQETSAQQSQEQGVGK 462
            ||             |.:.:.|:....:.:|..:.:.....::|      |..||...::..:.|
Human   348 KK-------------IWHFKYPIFFLCIGLDLQIGKLCAHSQQR------QYRSAYYPEDLFIDK 393

  Fly   463 SGNGGGGGGGNNRRQQQRRKQQQQRRKQQNNRDDNDDDDNESGGGREPILDRIVRDIRQRVKDYK 527
                               |..:....:                 .|..|....|::.|::|.:.
Human   394 -------------------KVLKVAHVE-----------------HEETLSSRRRELIQKLKSFI 422

  Fly   528 KFWSNLPHSVCSNEDIASSSDVDGMCWNG-HTIDRYMHSITTEHGSNPEFTGNPASTK----QTA 587
            .|:|.||..:||:..:|.:   |.:|||| ..::||... ...:|...:|..:....|    ..:
Human   423 SFYSALPGYICSHSPVAEN---DTLCWNGQELVERYSQK-AARNGMKNQFNLHELKMKGPEPVVS 483

  Fly   588 QMASQLSHLKNAIVHLRNAYNGQDVEWSEQEELPYAGSGAGSGSGSEDDEDDDEGSGLGPFEPSH 652
            |:..:|.|: |.::...:...|:.::.:..||      |..||...:|:::...|||.|..:..:
Human   484 QIIDKLKHI-NQLLRTMSMPKGRVLDKNLDEE------GFESGDCGDDEDECIGGSGDGMIKVKN 541

  Fly   653 K-PDVERPSVDADNDDDEDAGGRGHMPT 679
            : ..:...:.|.|.|   ||.|.....|
Human   542 QLRFLAELAYDLDVD---DAPGNSQQAT 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dlp	NP_524071.2	Glypican	79..613	CDD:279494	112/547 (20%)
GPC3	NP_001158089.1	Glypican	14..600	CDD:279494	137/660 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3821
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810