Protein Alignment dlp and GPC2

DIOPT Version :9

• Sequence 1: NP_524071.2
• Gene: dlp / 39596
• FlyBaseID: FBgn0041604
• Length: 765
• Species: Drosophila melanogaster
• Sequence 2: NP_689955.1
• Gene: GPC2 / 221914
• HGNCID: 4450
• Length: 579
• Species: Homo sapiens
• Alignment Length: 674
• Identity: 165/674 - (24%)
• Similarity: 272/674 - (40%)
• Gaps: 142/674 - (21%)

  Fly    31 PLLLLLLTTHLPPTLQADNGPAPQVAALAAPNPAGGVAGSSIIDQFSPNCSAVTHIFQARGIDAI 95
            |||||||.  |.|      ||.|      .|.....|..|         |:....:..|||....
Human     6 PLLLLLLP--LCP------GPGP------GPGSEAKVTRS---------CAETRQVLGARGYSLN 47

  Fly    96 EIPQKPSNERVLRYCESPSVGTCCTYNMETRMAMQSRQQLEGHTKDQISRMSGILGSKATKFKDI 160
            .||....:...||.|  |...|||:...|.|:..::.....|..:|..|.:...|.::..||.:.
Human    48 LIPPALISGEHLRVC--PQEYTCCSSETEQRLIRETEATFRGLVEDSGSFLVHTLAARHRKFDEF 110

  Fly   161 FTALLKESRTQFNSMFIRTYGVIYERNSYVFSDLFKELETYFANGRVDLLEVMDKFFNTLYQKMF 225
            |..:|..::.....:|..:||.:|.:::.:|:.||..|..::......|.:.:..|:..|.:::|
Human   111 FLEMLSVAQHSLTQLFSHSYGRLYAQHALIFNGLFSRLRDFYGESGEGLDDTLADFWAQLLERVF 175

  Fly   226 TVLNTQYTFDENYMRCVSEHMK----ELKPFGDVPDKLSVQIKRSFVATRTYGQALTTASEVAKK 286
            .:|:.||:|..:|:.|:|....    .|:||||.|.:|.:||.|:.||.|.:.|.|.|...|..:
Human   176 PLLHPQYSFPPDYLLCLSRLASSTDGSLQPFGDSPRRLRLQITRTLVAARAFVQGLETGRNVVSE 240

  Fly   287 VLNVRLNADCTGALTKMQHCGACKGYTE-KPCTNYCVNVIKGCLHYQHEFDSEWENFAMAMDKVA 350
            .|.|.::..|:.||.::..|..|:|... .||..:|:||::|||. ....:.:|.|:...:..:|
Human   241 ALKVPVSEGCSQALMRLIGCPLCRGVPSLMPCQGFCLNVVRGCLS-SRGLEPDWGNYLDGLLILA 304

  Fly   351 ERLLGSFNIVMVVEPLNIKISEAIMNFQDSGQDITNRVFQGCGRPKLKKMKRSISPKLQGVQILN 415
            ::|.|.|:..:..|.:.:||||.:|..|::...::.:|||.||.|
Human   305 DKLQGPFSFELTAESIGVKISEGLMYLQENSAKVSAQVFQECGPP-------------------- 349

  Fly   416 ARSPVEADTLDIDETLDEAIVLRERRAAEPGSQE---TSAQQSQEQGVGKSGNGGGGGGGNNRRQ 477
              .||.|               |.|||..|..:.   .|....:|:....:|..
Human   350 --DPVPA---------------RNRRAPPPREEAGRLWSMVTEEERPTTAAGTN----------- 386

  Fly   478 QQRRKQQQQRRKQQNNRDDNDDDDNESGGGREPILDRIVRDIRQRVKDYKKFWSNLPHSVCSNED 542
                                              |.|:|.::|:|:...:.||:.|..:||.:..
Human   387 ----------------------------------LHRLVWELRERLARMRGFWARLSLTVCGDSR 417

  Fly   543 IASSSDVDGM-CWNGHTIDRYMHSIT----TEHGSNPEF----TGNPASTKQTAQMASQLSHLKN 598
            :|:.:.::.. ||.|....||:..:.    .|..:|||.    :|....|::      :...|:.
Human   418 MAADASLEAAPCWTGAGRGRYLPPVVGGSPAEQVNNPELKVDASGPDVPTRR------RRLQLRA 476

  Fly   599 AIVHLRNAYNGQDVEWSEQEELPYAGSGAGSGSGSEDDEDDDEGSGLGPFEPSHKPDVERPSVDA 663
            |...::.|..|.|::..:.:|     ..:|||.|.:..:|...|:...|..|      .||....
Human   477 ATARMKTAALGHDLDGQDADE-----DASGSGGGQQYADDWMAGAVAPPARP------PRPPYPP 530

  Fly   664 DNDDDEDAGGRGHMPTHTSRPTSG 687
            ..|.....||.|....:..|..||
Human   531 RRDGSGGKGGGGSARYNQGRSRSG 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dlp	NP_524071.2	Glypican	79..613	CDD:279494	132/550 (24%)
GPC2	NP_689955.1	Glypican	29..512	CDD:279494	138/587 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	444..468		5/23 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	485..555		20/81 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147852
Domainoid	1	1.000	286	1.000	Domainoid score	I1604
eggNOG	1	0.900	-	-		E1_KOG3821
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46379
OrthoDB	1	1.010	-	-		D275653at33208
OrthoFinder	1	1.000	-	-		FOG0000903
OrthoInspector	1	1.000	-	-		otm41759
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10822
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X519
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.820