Protein Alignment dlp and GPC6

DIOPT Version :9

• Sequence 1: NP_524071.2
• Gene: dlp / 39596
• FlyBaseID: FBgn0041604
• Length: 765
• Species: Drosophila melanogaster
• Sequence 2: NP_005699.1
• Gene: GPC6 / 10082
• HGNCID: 4454
• Length: 555
• Species: Homo sapiens
• Alignment Length: 653
• Identity: 222/653 - (33%)
• Similarity: 316/653 - (48%)
• Gaps: 134/653 - (20%)

  Fly    31 PLLLLLLTTHLPPTLQADNGPAPQVAALAAPNPAGGVAGSSIIDQFSPNCSAVTHIFQARGIDAI 95
            |||.|||:.                       |||.       |..:.:|..|...:.|:|....
Human    11 PLLGLLLSL-----------------------PAGA-------DVKARSCGEVRQAYGAKGFSLA 45

  Fly    96 EIPQKPSNERVLRYCESPSVGTCCTYNMETRMAMQSRQQLEGHTKDQISRMSGILGSKATKFKDI 160
            :||.:......||.|  |...||||..||.:::.||:.:.|...::....:.....|:..||.:.
Human    46 DIPYQEIAGEHLRIC--PQEYTCCTTEMEDKLSQQSKLEFENLVEETSHFVRTTFVSRHKKFDEF 108

  Fly   161 FTALLKESRTQFNSMFIRTYGVIYERNSYVFSDLFKELETYFANGRVDLLEVMDKFFNTLYQKMF 225
            |..||:.:....|.||:||||::|.:||.||.|||.||:.|:..|.|:|.|:::.|:..|.::||
Human   109 FRELLENAEKSLNDMFVRTYGMLYMQNSEVFQDLFTELKRYYTGGNVNLEEMLNDFWARLLERMF 173

  Fly   226 TVLNTQYTFDENYMRCVSEHMKELKPFGDVPDKLSVQIKRSFVATRTYGQALTTASEVAKKVLNV 290
            .::|.||.|.|:|:.|||::..:||||||||.||.:|:.|:|:|.||:.|.||...|||.:|..|
Human   174 QLINPQYHFSEDYLECVSKYTDQLKPFGDVPRKLKIQVTRAFIAARTFVQGLTVGREVANRVSKV 238

  Fly   291 RLNADCTGALTKMQHCGACKGY-TEKPCTNYCVNVIKGCLHYQHEFDSEWENFAMAMDKVAERLL 354
            .....|..||.||.:|..|:|. |.:||.|||:||:||||..|.:.|:||..|..||..|||||.
Human   239 SPTPGCIRALMKMLYCPYCRGLPTVRPCNNYCLNVMKGCLANQADLDTEWNLFIDAMLLVAERLE 303

  Fly   355 GSFNIVMVVEPLNIKISEAIMNFQDSGQDITNRVFQGCGRPKLKKMKRSISPKLQGVQILNARS- 418
            |.|||..|::|:::||||||||.|::...::.:||||||:||.....||            |||
Human   304 GPFNIESVMDPIDVKISEAIMNMQENSMQVSAKVFQGCGQPKPAPALRS------------ARSA 356

  Fly   419 PVEADTLDIDETLDEAIVLRERRAAEPGSQETSAQQSQEQGVGKSGNGGGGGGGNNRRQQQRRKQ 483
            |...:|              ..|...|..:.|:|       .|.|
Human   357 PENFNT--------------RFRPYNPEERPTTA-------AGTS-------------------- 380

  Fly   484 QQQRRKQQNNRDDNDDDDNESGGGREPILDRIVRDIRQRVKDYKKFWSNLPHSVCSNEDIASSSD 548
                                        |||:|.||::::|..||.||.||:::|.:|.:.:.:.
Human   381 ----------------------------LDRLVTDIKEKLKLSKKVWSALPYTICKDESVTAGTS 417

  Fly   549 VDGMCWNGHTIDRYMHSI----TTEHGSNPEFTGNPASTKQTAQMASQLSHLKNAIVHLRNAYNG 609
            .:..|||||:..||:..|    .|...:|||.  :...|:....:..|:..|:.....|:|||||
Human   418 NEEECWNGHSKARYLPEIMNDGLTNQINNPEV--DVDITRPDTFIRQQIMALRVMTNKLKNAYNG 480

  Fly   610 QDVEWSEQEELPYAGSGAGSGSGSEDDEDDDEGSGLGPFEPSHKPDVERPSVDADNDD-DEDAGG 673
            .||.:.:..:   ..||:|||||..||....|      ||   ....|.|:||.|..: |..|..
Human   481 NDVNFQDTSD---ESSGSGSGSGCMDDVCPTE------FE---FVTTEAPAVDPDRREVDSSAAQ 533

  Fly   674 RGH 676
            |||
Human   534 RGH 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dlp	NP_524071.2	Glypican	79..613	CDD:279494	189/539 (35%)
GPC6	NP_005699.1	Glypican	22..548	CDD:307347	214/619 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	348..376		10/53 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	480..501		9/23 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	286	1.000	Domainoid score	I1604
eggNOG	1	0.900	-	-		E1_KOG3821
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	373	1.000	Inparanoid score	I2117
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46379
OrthoDB	1	1.010	-	-		D275653at33208
OrthoFinder	1	1.000	-	-		FOG0000903
OrthoInspector	1	1.000	-	-		otm41759
orthoMCL	1	0.900	-	-		OOG6_105830
Panther	1	1.100	-	-	O	PTHR10822
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3318
SonicParanoid	1	1.000	-	-		X519
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.870