DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dlp and gpc6b

DIOPT Version :9

Sequence 1:	NP_524071.2	Gene:	dlp / 39596	FlyBaseID:	FBgn0041604	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	NP_001274470.1	Gene:	gpc6b / 100331176	ZFINID:	ZDB-GENE-130515-2	Length:	543	Species:	Danio rerio

Alignment Length:	563	Identity:	175/563 - (31%)
Similarity:	274/563 - (48%)	Gaps:	101/563 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 NCSAVTHIFQARGIDAIEIPQKPSNERVLRYCESPSVGTCCTYNMETRMAMQSRQQLEGHTKDQI 143
            |||.|...:.|.|..:.::|.:.::...||.| :| :..||...||...:.:|....:....|..
Zfish    20 NCSLVKDAYSALGFSSDDVPAEQTSGEDLRVC-AP-LEACCNTQMEESFSHRSSHDFQKLMDDAS 82

  Fly   144 SRMSGILGSKATKFKDIFTALLKESRTQFNSMFIRTYGVIYERNSYVFSDLFKELETYFANGRVD 208
            ..:.....|...:|.|.|..||:.:....|.||:||||..|.:|:.||..||.||..::..|.|:
Zfish    83 EELRDTFMSGHKRFDDFFLELLESAERSLNEMFVRTYGKPYLQNAEVFQSLFSELRRFYTGGNVN 147

  Fly   209 LLEVMDKFFNTLYQKMFTVLNTQYTFDENYMRCVSEHMKELKPFGDVPDKLSVQIKRSFVATRTY 273
            |.|::..|:..|.::||.:||:|:...:.|:.|:.::.::|:||||||.||..|:.|:|:|.||:
Zfish   148 LEEMLKDFWTRLLERMFQLLNSQFQITDEYLECIGKYTEQLRPFGDVPKKLKSQVTRAFIAARTF 212

  Fly   274 GQALTTASEVAKKVLNVRLNADCTGALTKMQHCGACKG-YTEKPCTNYCVNVIKGCLHYQHEFDS 337
            .|.|....:||.:|..|.:::.|....|||.:|..|:| :|.|||.|||:||:||||..|.:.::
Zfish   213 VQGLAVGRDVANRVAQVSMSSSCVSGFTKMLYCSYCQGLFTLKPCRNYCLNVMKGCLANQADLNN 277

  Fly   338 EWENFAMAMDKVAERLLGSFNIVMVVEPLNIKISEAIMNFQDSGQDITNRVFQGCGRPKLKKMKR 402
            ||..|..|:..:.|||.|.|||..|:||:::||||||||.|::...::.:||||||:|:...|.|
Zfish   278 EWSKFIDALLLLTERLEGPFNIESVMEPIDVKISEAIMNMQENSMQLSYQVFQGCGQPEPAGMTR 342

  Fly   403 SISPKLQGVQILNARSPVEADTLDIDETLDEAIVLRERRAAEPGSQETSAQQSQEQGVGKSGNGG 467
            |            |||                                         |..|.:|
Zfish   343 S------------ARS-----------------------------------------VHDSFSG- 353

  Fly   468 GGGGGNNRRQQQRRKQQQQRRKQQNNRDDNDDDDNESGGGREPILDRIVRDIRQRVKDYKKFWSN 532
                        |.|..::.....:...                |.|:|.::::::|.::.||.:
Zfish   354 ------------RFKPYEELPTVASGAP----------------LHRLVSEMKEKLKHFQSFWVS 390

  Fly   533 LPHSVCSNEDIASSSDV-DGMCWNGHTIDRYMHSI----TTEHGSNPEFT---GNPASTKQTAQM 589
            ||...|.:|.|::.... |..|||||...||:..:    ..:..||||.:   ..|.|..:...:
Zfish   391 LPLVFCKDEQISADGQTEDQQCWNGHHSGRYIAEVQKDGLAQQASNPEVSVDVSRPDSLIRQQIL 455

  Fly   590 ASQLSHLKNAIVHLRNAYNGQDVEWSEQEELPYAGSGAGSGSG 632
            |.::...|     |:|||:|.|:.:.:..|   ..||:|||||
Zfish   456 ALRIMSNK-----LKNAYDGHDINFQDSNE---ESSGSGSGSG 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dlp	NP_524071.2	Glypican	79..613	CDD:279494	167/542 (31%)
gpc6b	NP_001274470.1	Glypican	4..526	CDD:279494	175/563 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	278	1.000	Domainoid score	I1678
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	353	1.000	Inparanoid score	I2219
OMA	1	1.010	-	-		QHG46379
OrthoDB	1	1.010	-	-		D275653at33208
OrthoFinder	1	1.000	-	-		FOG0000903
OrthoInspector	1	1.000	-	-		otm24302
orthoMCL	1	0.900	-	-		OOG6_105830
Panther	1	1.100	-	-	O	PTHR10822
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X519
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.980