Protein Alignment RecQ5 and RECQL5

DIOPT Version :10

• Sequence 1: NP_729983.1
• Gene: RecQ5 / 39594
• FlyBaseID: FBgn0027375
• Length: 1058
• Species: Drosophila melanogaster
• Sequence 2: XP_005257875.1
• Gene: RECQL5 / 9400
• HGNCID: 9950
• Length: 1012
• Species: Homo sapiens
• Alignment Length: 1102
• Identity: 365/1102 - (33%)
• Similarity: 532/1102 - (48%)
• Gaps: 167/1102 - (15%)

  Fly     4 ESAVHEALKKHFGHSKFKSDLQEKAVKCAVKKKQDVYVSMPTGSGKSLCFQLPGLMSENQITIVF 68
            |..|...|||.||...||:.|||.|....||..:||:|.||||:|||||:|||.|:::. ||||.
Human    13 ERRVRSTLKKVFGFDSFKTPLQESATMAVVKGNKDVFVCMPTGAGKSLCYQLPALLAKG-ITIVV 76

  Fly    69 SPLLALIKDQIDHLTKLKVPADSLNSKMSTKERDRVIMDLKAVRTNLKFLYITPEQAATKFFQDL 133
            |||:|||:||:|||..|||...|||||:|.:||..::.||:..:...|.||||||.||:..||..
Human    77 SPLIALIQDQVDHLLTLKVRVSSLNSKLSAQERKELLADLEREKPQTKILYITPEMAASSSFQPT 141

  Fly   134 LQTLHKHNKLAYFAVDEAHCVSQWGHDFRPDYLKLGELRSKYSDVIWLALTATASREVKEDIYKQ 198
            |.:|...:.|:|..|||||||||||||||||||:||.|||:......:||||||:.:|:||::..
Human   142 LNSLVSRHLLSYLVVDEAHCVSQWGHDFRPDYLRLGALRSRLGHAPCVALTATATPQVQEDVFAA 206

  Fly   199 LRLHQPVAQFSTPSFRKNLFYDIVYKNSIEDDFQHLADFARHCLGNPKEFKDTPKPQRGCGIVYC 263
            |.|.:|||.|.||.||.|||||:.:|..|.|.:.:|.||....||     ::..|...|||||||
Human   207 LHLKKPVAIFKTPCFRANLFYDVQFKELISDPYGNLKDFCLKALG-----QEADKGLSGCGIVYC 266

  Fly   264 RTRDQVERMAIGVTKQGIGAVAYHAGLKTGERTEVQEAWMRGDQPIICATNSFGMGVDKPSVRFV 328
            |||:..|::||.::.:|:.|.|||||||..|||.||..||....|:|.||.||||||||.:||||
Human   267 RTREACEQLAIELSCRGVNAKAYHAGLKASERTLVQNDWMEEKVPVIVATISFGMGVDKANVRFV 331

  Fly   329 IHWDVPQNVAAYYQESGRAGRDGLQSYCRLYYGREDVRSIRFLLQNDAHRARGRGDKELLTERAI 393
            .||::.:::|.||||||||||||..|:|||||.|.|...:.||::.:..:.:.:...:...:..|
Human   332 AHWNIAKSMAGYYQESGRAGRDGKPSWCRLYYSRNDRDQVSFLIRKEVAKLQEKRGNKASDKATI 396

  Fly   394 KQFEKITEFCERTTCRHKLFSDFFGDPTPDCSGQCDVCKRPKKAEKALEIFHR------LCMDDA 452
            ..|:.:..|||...|||...:.:|||..|.|:..||.|:.|....:.||...|      .|:..:
Human   397 MAFDALVTFCEELGCRHAAIAKYFGDALPACAKGCDHCQNPTAVRRRLEALERSSSWSKTCIGPS 461

  Fly   453 FKSHISLQDCADLYEGGRPGIKRAAQEYAGGESGSDDDS-GQSHSSMAKRAKKESQDFIKQQFNL 516
            ..:...    .:||||||.|....:: |..|..||.|:. .::|       |:|...|.::|..|
Human   462 QGNGFD----PELYEGGRKGYGDFSR-YDEGSGGSGDEGRDEAH-------KREWNLFYQKQMQL 514

  Fly   517 RK----QISAARQLEQETIAQISRVRMAEATEKKIAGLQATHREKYLTALIDALKANVDKCKDEP 577
            ||    :|       :|.:.......:.||:.::|..|....||..|..|.:||.:|
Human   515 RKGKDPKI-------EEFVPPDENCPLKEASSRRIPRLTVKAREHCLRLLEEALSSN-------- 564

  Fly   578 GQQPKSVLKYNDYEAMSVNMEYDVFRQNKVANMYRHALVKEISTIKKLTEQTKLLPLLVDYIPKP 642
             :|........|..|.:|.:|::.||..||||:|:.:::|:::.|.:.::..:...:
Human   565 -RQSTRTADEADLRAKAVELEHETFRNAKVANLYKASVLKKVADIHRASKDGQPYDM-------- 620

  Fly   643 ETSSKGAWTGGSVAYFERKLKELEEQRPQSLK-EVPKA-----LKDRKGFKQENSKQTSISSFFK 701
                     |||.     |....:.:.|:..: ::|.|     ||.::           :.:.|.
Human   621 ---------GGSA-----KSCSAQAEPPEPNEYDIPPASHVYSLKPKR-----------VGAGFP 660

  Fly   702 KEIKEEPIDSPIQEERVNIKSEQMDLEESTPKDIASNHVKEESVTPESSSSDRELELQPDSIIGE 766
            |.      ..|.|        ...:|.|:|       .::|::..|| ...:.|...:|..::.|
Human   661 KG------SCPFQ--------TATELMETT-------RIREQAPQPE-RGGEHEPPSRPCGLLDE 703

  Fly   767 RKFKLMSNGDGSYD-THRRKRV----SHETQPKEKESIKTKSSMQHLFGSFKSESEE-------- 818
                     |||.. ...|..|    :|...|..::..|:.|....|.....|:.::
Human   704 ---------DGSEPLPGPRGEVPGGSAHYGGPSPEKKAKSSSGGSSLAKGRASKKQQLLATAAHK 759

  Fly   819 SNQSLNGFKTARQMLEENNSKLEGVPE---KLPIKDG--------EKRVLENRADSIGFTS---- 868
            .:||:..|...|   .|:.:.|...||   ..|..:|        ||...|.  |..|..|
Human   760 DSQSIARFFCRR---VESPALLASAPEAEGACPSCEGVQGPPMAPEKYTGEE--DGAGGHSPAPP 819

  Fly   869 -----AREMLERSKQREGDDKSSNKLEKLGFISAREMLEKNKLNERCLDKKDV-KEKKLESRETK 927
                 .||.......||....|: .:..|...|.....::.....:....||. |.|:..|::
Human   820 QTEECLRERPRPPGMREPPGPSA-VMPALPSTSTCPPRDQGTPEVQPTPAKDTWKGKRPRSQQ-- 881

  Fly   928 RSLQNNELQHKQEEDRKDKASHRKTSKESLSNLKKEGSDSRVLQKDTKPETRNHQKTDVSKNVVQ 992
               :|.|.|.::......|.|.....|.|:| ..::|:.:...|...:.........:.:..||:
Human   882 ---ENPESQPQKRPRPSAKPSVVAEVKGSVS-ASEQGTLNPTAQDPFQLSAPGVSLKEAANVVVK 942

  Fly   993 WLNPYYKR-KIATKELFKALAK----LLTQRICDGSLGDGDAGKCYIKETFHGLQMINNDQD 1049
            .|.|:||. |.|:|||||..|:    ||||:...|.....:| :..|:..|||.....::.|
Human   943 CLTPFYKEGKFASKELFKGFARHLSHLLTQKTSPGRSVKEEA-QNLIRHFFHGRARCESEAD 1003

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RecQ5	NP_729983.1	RecQ	5..447	CDD:440280	220/447 (49%)
		SMC_N	658..>963	CDD:481474	66/344 (19%)
RECQL5	XP_005257875.1	RecQ	14..449	CDD:440280	219/440 (50%)
		RecQ5	625..826	CDD:399738	46/247 (19%)
		PRK12323	<772..>937	CDD:481241	34/173 (20%)