DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RecQ5 and SGS1

DIOPT Version :9

Sequence 1:	NP_729983.1	Gene:	RecQ5 / 39594	FlyBaseID:	FBgn0027375	Length:	1058	Species:	Drosophila melanogaster
Sequence 2:	NP_013915.1	Gene:	SGS1 / 855228	SGDID:	S000004802	Length:	1447	Species:	Saccharomyces cerevisiae

Alignment Length:	869	Identity:	244/869 - (28%)
Similarity:	392/869 - (45%)	Gaps:	192/869 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 HSKFK----SDLQEKAVKCAVKKKQDVYVSMPTGSGKSLCFQLPGLMSENQ---ITIVFSPLLAL 74
            |..||    ...|.:||...::.| ||:|.||||.|||||:|||.::...:   .|||.|||::|
Yeast   671 HEVFKLPGFRPNQLEAVNATLQGK-DVFVLMPTGGGKSLCYQLPAVVKSGKTHGTTIVISPLISL 734

  Fly    75 IKDQIDHLTKLKVPADSLNSKMSTKERDRVIMDLKAVRTNLKFLYITPEQ-AATKFFQDLLQTLH 138
            ::||::||....:.| |:.|...|.|:.|...:| .:...|..:||:||. :|::..:..:..|:
Yeast   735 MQDQVEHLLNKNIKA-SMFSSRGTAEQRRQTFNL-FINGLLDLVYISPEMISASEQCKRAISRLY 797

  Fly   139 KHNKLAYFAVDEAHCVSQWGHDFRPDYLKLGELRSKYSDVIWLALTATASREVKEDIYKQLRLHQ 203
            ...|||...||||||||.|||||||||.:|...:.:|.|:..:|||||||.:|:.||...|.|.:
Yeast   798 ADGKLARIVVDEAHCVSNWGHDFRPDYKELKFFKREYPDIPMIALTATASEQVRMDIIHNLELKE 862

  Fly   204 PVAQFSTPSF-RKNLFYDI--VYKNSIEDDFQHLADFARHCLGNPKEFKDTPKPQRGCGIVYCRT 265
            ||  |...|| |.||:|::  ..||:|.:    :.|..:      ..||:.      .||:||.:
Yeast   863 PV--FLKQSFNRTNLYYEVNKKTKNTIFE----ICDAVK------SRFKNQ------TGIIYCHS 909

  Fly   266 RDQVERMAIGVTKQGIGAVAYHAGLKTGERTEVQEAWMRGDQPIICATNSFGMGVDKPSVRFVIH 330
            :...|:.:..:.:.||....||||::..||..||:||...:..:||||.:||||:|||.||||.|
Yeast   910 KKSCEQTSAQMQRNGIKCAYYHAGMEPDERLSVQKAWQADEIQVICATVAFGMGIDKPDVRFVYH 974

  Fly   331 WDVPQNVAAYYQESGRAGRDGLQSYCRLYYGREDVRSIRFLLQNDAHRARGRGDKELLTERAIKQ 395
            :.||:.:..||||:|||||||..|||..|:...|:|:::.::|.|.:..|...:|.|      .:
Yeast   975 FTVPRTLEGYYQETGRAGRDGNYSYCITYFSFRDIRTMQTMIQKDKNLDRENKEKHL------NK 1033

  Fly   396 FEKITEFCERTT-CRHKLFSDFFGDPTPD--CSGQCDVCKR-----------PKKAEKALEIFHR 446
            .:::..:|:..| ||.||...:|.:....  |...||.|:.           .:.|:|.:::
Yeast  1034 LQQVMAYCDNVTDCRRKLVLSYFNEDFDSKLCHKNCDNCRNSANVINEERDVTEPAKKIVKL--- 1095

  Fly   447 LCMDDAFKSHISLQDCADLYEGGRP--------------GIK------------------RAAQE 479
              ::......:::..|.|:::|.|.              ||.                  |..||
Yeast  1096 --VESIQNERVTIIYCQDVFKGSRSSKIVQANHDTLEEHGIGKSMQKSEIERIFFHLITIRVLQE 1158

  Fly   480 YAGGESGSDDDSG--QSHSSMAKRAKK--ESQDFIKQQF-----NLRKQISAARQLEQETIAQIS 535
            |:     ..::||  .|:..:...|||  ..:..||.||     |.|...|::.|..::.|..|:
Yeast  1159 YS-----IMNNSGFASSYVKVGPNAKKLLTGKMEIKMQFTISAPNSRPSTSSSFQANEDNIPVIA 1218

  Fly   536 RVRMAEATEKKIAGLQATHREKYLTALIDALKANVDKCKDEPGQQPKSVLKYND----YEAMSVN 596
            :      ....|.|..|.:..::::|. :.|::............|.::...:|    .|..::.
Yeast  1219 Q------KSTTIGGNVAANPPRFISAK-EHLRSYTYGGSTMGSSHPITLKNTSDLRSTQELNNLR 1276

  Fly   597 MEYDVFRQ------NK----VANMYRHALVKEISTIKKLTEQTKLLPLLVDYIPKPETSSKGAWT 651
            |.|:..|:      |:    |.|....:::|:::.|         ||:          :.....|
Yeast  1277 MTYERLRELSLNLGNRMVPPVGNFMPDSILKKMAAI---------LPM----------NDSAFAT 1322

  Fly   652 GGSV--------AYFERKLKELEEQRPQSLKE----------VPKALKDRKGFKQENSKQTSISS 698
            .|:|        .||:..:.:|.::|.....|          |.:|.....|..|....:   |.
Yeast  1323 LGTVEDKYRRRFKYFKATIADLSKKRSSEDHEKYDTILNDEFVNRAAASSNGIAQSTGTK---SK 1384

  Fly   699 FFKKEIKEEPIDSPIQEERVN-IKSEQMDLEESTPKDIASNHVKEESVTPESSSSDRELELQPDS 762
            ||...:.|    :...|:.:| |:..|:      ||:..|:.....|::..|..|..
Yeast  1385 FFGANLNE----AKENEQIINQIRQSQL------PKNTTSSKSGTRSISKSSKKSAN-------- 1431

  Fly   763 IIGERKFKLMSNGDGSYDTHRRKR 786
              |.|.|:       :|..|.|.|
Yeast  1432 --GRRGFR-------NYRGHYRGR 1446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RecQ5	NP_729983.1	RecQ	6..>442	CDD:223588	167/449 (37%)
		DEAD	37..193	CDD:278688	71/159 (45%)
		HELICc	<257..359	CDD:238034	49/101 (49%)
		RecQ_Zn_bind	364..431	CDD:292742	17/69 (25%)
SGS1	NP_013915.1	RecQ	670..1350	CDD:223588	218/741 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0514
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R580
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840