DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RecQ5 and RECQ4B

DIOPT Version :9

Sequence 1:	NP_729983.1	Gene:	RecQ5 / 39594	FlyBaseID:	FBgn0027375	Length:	1058	Species:	Drosophila melanogaster
Sequence 2:	NP_176289.7	Gene:	RECQ4B / 842384	AraportID:	AT1G60930	Length:	1150	Species:	Arabidopsis thaliana

Alignment Length:	756	Identity:	218/756 - (28%)
Similarity:	353/756 - (46%)	Gaps:	134/756 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 FGHSKFKSDLQEKAVKCAVKKKQDVYVSMPTGSGKSLCFQLPGLMSENQITIVFSPLLALIKDQI 79
            ||:..|:.:.:|  :..|.....||:|.||||.||||.:|||.|:... ||:|.|||::||:|||
plant   465 FGNHSFRPNQRE--IINATMSGCDVFVLMPTGGGKSLTYQLPALLCAG-ITLVISPLVSLIQDQI 526

  Fly    80 DHLTKLKVPADSLNSKMSTKERDRVIMDLKAVRTNLKFLYITPEQAATKFFQDL---LQTLHKHN 141
            .:|.:..:.|.||::.|...|:..::.:|.:.::..|.||:|||:.|..  :.|   |:.|:..:
plant   527 MNLLQTNISAASLSAGMEWAEQLEILQELSSEKSKYKLLYVTPEKVAKS--ESLLRHLEILNSRS 589

  Fly   142 KLAYFAVDEAHCVSQWGHDFRPDYLKLGELRSKYSDVIWLALTATASREVKEDIYKQLRLHQPVA 206
            .||.|.:|||||||||||||||||..||.|:.|:.::..|||||||:..||||:.:.|.|...|.
plant   590 LLARFVIDEAHCVSQWGHDFRPDYQGLGVLKQKFPNIPMLALTATATTSVKEDVVQALGLVNCVV 654

  Fly   207 QFSTPSFRKNLFYDIVYKNS--IEDDFQHLADFARHCLGNPKEFKDTPKPQRGCGIVYCRTRDQV 269
             |.....|.||:|.:|.|.:  :||    :..|.|.     ..|.:       |||:||.:|...
plant   655 -FRQSFNRPNLWYSVVPKTNKCLED----IDKFIRE-----NHFDE-------CGIIYCLSRMDC 702

  Fly   270 ERMAIGVTKQGIGAVAYHAGLKTGERTEVQEAWMRGDQPIICATNSFGMGVDKPSVRFVIHWDVP 334
            |::...:...|..|..||..:..|:|..||:.|.:.:..|||||.:||||::||.||||||..:|
plant   703 EKVTEALRVFGHKAAFYHGSMDPGKRAFVQKQWSKDEINIICATVAFGMGINKPDVRFVIHHSLP 767

  Fly   335 QNVAAYYQESGRAGRDGLQSYCRLYYGREDVRSIRFLLQNDAHRARGRGDKEL----------LT 389
            :::..|:||.|||||||.:|.|.|||...|...::.::   :....|:|..::          :.
plant   768 KSIEGYHQECGRAGRDGQRSSCVLYYSYTDYIRVKHMI---SQGGLGQGQMKMGYNCKASSGRML 829

  Fly   390 ERAIKQFEKITEFCE-RTTCRHKLFSDFFGD--PTPDCSGQCDVCKRPK-KAEKALEIFHRLCM- 449
            |...:...::..:|| ...||..|.....|:  .:.:|...||.|...| ..:|.:.:..|..:
plant   830 ETNTENLLRMVSYCENEVDCRRFLQLVHLGEKFDSTNCKNTCDNCSSSKILIDKDVTVIARQLVA 894

  Fly   450 -----DDAFKS-HISLQDCADLYEGG-RPGIKRAAQE----YAGGESGSDDDSGQ---------- 493
                 .:.|.| ||     .::|.|. ...:||..|:    :..|:..:..::.:
plant   895 LVKLTGERFSSAHI-----VEIYRGSLNQSVKRNRQDTLHLHGAGKHLTKSEASRILHYLVTEDI 954

  Fly   494 ------------SHSSMAKRAKKESQDFIK--QQFNLRKQISAARQLEQETIAQISRVRMAEATE 544
                        |.||:.|..:.::...:.  |...:|...:.....:.::.|..::|.:.:.|
plant   955 LAEGVKKSELYGSVSSLLKVNRSKAASLLSGGQSITMRFPSTIKVSKQSKSTANPAKVPLKQTT- 1018

  Fly   545 KKIAGLQATHREKYLTA-LIDALK-ANVDKCKDEPGQQPKSVLKYNDYEAMSVNMEYDVFRQNKV 607
              :...:|..::..|:. |:.||| ...|..|:.|                .:.|.|.:|
plant  1019 --LPMAKAAPQDSNLSGILLTALKNLRTDIVKESP----------------DLVMAYHIF----- 1060

  Fly   608 ANMYRHALVKEISTIKKLTEQTKLLPLLVDYIPKPETSSKGAWTGGSVAYFERKLKELEEQRPQS 672
                .:|.:||||   |...:||...|.::.:.|.:.|.          |.:|.|:.::......
plant  1061 ----GNATLKEIS---KRLPRTKEELLDINGLGKAKVSK----------YGDRLLETIDSTINDH 1108

  Fly   673 LKEVPKALKDRK------GFKQENSKQTSISSFFKKEIKEE 707
            .|..|.:.|.|:      ...:::....|.|...||.:|.:
plant  1109 YKTRPGSGKRRRDENVNPNVAEDDDPDWSASQSHKKVVKNK 1149

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RecQ5	NP_729983.1	RecQ	6..>442	CDD:223588	163/445 (37%)
		DEAD	37..193	CDD:278688	75/158 (47%)
		HELICc	<257..359	CDD:238034	46/101 (46%)
		RecQ_Zn_bind	364..431	CDD:292742	13/79 (16%)
RECQ4B	NP_176289.7	PLN03137	14..1150	CDD:215597	218/756 (29%)
		DEAD	471..641	CDD:278688	77/174 (44%)
		HELICc	666..792	CDD:238034	54/141 (38%)
		RecQ_Zn_bind	797..874	CDD:292742	13/79 (16%)
		RQC	883..994	CDD:286470	18/115 (16%)
		HRDC	1035..1101	CDD:278967	24/103 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0514
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D445763at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820