DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RecQ5 and RECQ4A

DIOPT Version :9

Sequence 1:	NP_729983.1	Gene:	RecQ5 / 39594	FlyBaseID:	FBgn0027375	Length:	1058	Species:	Drosophila melanogaster
Sequence 2:	NP_172562.2	Gene:	RECQ4A / 837636	AraportID:	AT1G10930	Length:	1188	Species:	Arabidopsis thaliana

Alignment Length:	836	Identity:	239/836 - (28%)
Similarity:	375/836 - (44%)	Gaps:	173/836 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 KKHFGHSKFKSDLQEKAVKCAVKKKQDVYVSMPTGSGKSLCFQLPGLMSENQITIVFSPLLALIK 76
            ||.||:..|:.:.:|  :..|.....||:|.||||.||||.:|||.|:. ..||:|.|||::||:
plant   446 KKVFGNHSFRPNQRE--IINATMSGSDVFVLMPTGGGKSLTYQLPALIC-GGITLVISPLVSLIQ 507

  Fly    77 DQIDHLTKLKVPADSLNSKMSTKERDRVIMDLKAVRTNLKFLYITPEQAATKFFQDLLQTLHKHN 141
            |||.:|.:..:||.||::.|...|:.::..:|.:..:..|.||:|||:.|..  ..||:.|...|
plant   508 DQIMNLLQANIPAASLSAGMEWAEQLKIFQELNSEHSKYKLLYVTPEKVAKS--DSLLRHLENLN 570

  Fly   142 K---LAYFAVDEAHCVSQWGHDFRPDYLKLGELRSKYSDVIWLALTATASREVKEDIYKQLRLHQ 203
            .   ||.|.:|||||||||||||||||..||.|:.|:.::..|||||||:..||||:.:.|.|..
plant   571 SRGLLARFVIDEAHCVSQWGHDFRPDYQSLGILKQKFPNIPVLALTATATASVKEDVVQALGLVN 635

  Fly   204 PVAQFSTPSFRKNLFYDIVYKNSIEDDFQHLADFARHCLGNPKEF-KDTPKPQRGCGIVYCRTRD 267
            .|. |.....|.||:|.:|.|             .:.||.:..:| |:....:  |||:||.:|.
plant   636 CVV-FRQSFNRPNLWYSVVPK-------------TKKCLEDIDKFIKENHFDE--CGIIYCLSRM 684

  Fly   268 QVERMAIGVTKQGIGAVAYHAGLKTGERTEVQEAWMRGDQPIICATNSFGMGVDKPSVRFVIHWD 332
            ..|:::..:.:.|..|..||..::..:|..:|..|.:.:..|||||.:||||::||.||||||..
plant   685 DCEKVSERLQEFGHKAAFYHGSMEPEQRAFIQTQWSKDEINIICATVAFGMGINKPDVRFVIHHS 749

  Fly   333 VPQNVAAYYQESGRAGRDGLQSYCRLYYGREDVRSIRFLLQNDA----------HRARGRGDKEL 387
            :|:::..|:||.|||||||.:|.|.||||..|...::.::....          :|....|   .
plant   750 LPKSIEGYHQECGRAGRDGQRSSCVLYYGYGDYIRVKHMISQGGVDQSPMATGYNRVASSG---R 811

  Fly   388 LTERAIKQFEKITEFCE-RTTCRHKLFSDFFGD--PTPDCSGQCD-VCKRPKKAEKALEIFHRLC 448
            |.|...:...::..:|| ...||..|.....|:  .:.:|...|| .|......:|.:.:..|..
plant   812 LLETNTENLLRMVRYCENEVECRRFLQLVHLGEKFDSTNCKKTCDNCCSSQSLIDKDVTLITRQL 876

  Fly   449 MD------DAFKS-HISLQDCADLYEGGRPGIKRAAQEYAGGESGSDDDSGQSHSSMAKRAKKES 506
            ::      :.|.| ||     .::|.|                         |.:.|.|:.:.|:
plant   877 VELVKQTGERFSSAHI-----LEVYRG-------------------------SLNQMVKKHRHET 911

  Fly   507 QDFIKQQFNLRKQISAARQLEQETIAQISRVRMAEATEKKIAGLQATHREKYLTALIDALKANVD 571
            ..|          ..|.:.|.:   .::||:.....||                   |.|..:|.
plant   912 LQF----------HGAGKHLSK---IEVSRILHYLVTE-------------------DILVEDVR 944

  Fly   572 KCKDEPGQQPKSVLKYNDYEAMSVNMEYDVFRQNKVANMYRHALVKEISTIKK---------LTE 627
            | .|..| ...|:|:.|:.:|..      :|..::...|...:.||.:...|:         .:|
plant   945 K-SDMYG-SVSSLLQVNNAKATI------LFSGSQTIVMKFPSSVKVLKPSKQGATAAKGPLTSE 1001

  Fly   628 QTKLLPLLV-DYIPKPETSSKGAWTG--------------GSVAY---FERKLKELEEQRPQSLK 674
            :...|||.. |..||....|...:|.              |.:||   ....|:::..:.|::.:
plant  1002 KQSTLPLTTEDAPPKDVNLSANMYTALRKLRTALVKEAPDGVMAYHIFINSTLQQISRRIPRTKE 1066

  Fly   675 E------VPKALKDRKGFKQENSKQTSISSFFKKEIKEEPI--DSP-----IQEERVNIKSEQMD 726
            |      :.||...:.|.:...:.:|:::.::....|:..|  |||     .::|.::....:.|
plant  1067 ELLEINGLGKAKVSKYGDQLLETIETTVNEYYGTNKKDSIISNDSPDSGKRRRDENISPNVAEDD 1131

  Fly   727 LEESTPKDIASNHVKEES---VTPESSSSDRE-LELQPDSIIGERKFKLMSNGDGS 778
            ..|.:|.......|:.:|   :..|....||. :||..|       ||   :.|||
plant  1132 DFEVSPSQSCKKTVRNKSNEVLHGECIDGDRRGMELDFD-------FK---DEDGS 1177

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RecQ5	NP_729983.1	RecQ	6..>442	CDD:223588	165/447 (37%)
		DEAD	37..193	CDD:278688	77/158 (49%)
		HELICc	<257..359	CDD:238034	44/101 (44%)
		RecQ_Zn_bind	364..431	CDD:292742	14/80 (18%)
RECQ4A	NP_172562.2	PLN03137	1..1188	CDD:215597	239/836 (29%)
		DEAD	455..625	CDD:278688	79/174 (45%)
		HELICc	650..776	CDD:238034	51/140 (36%)
		RecQ_Zn_bind	781..858	CDD:292742	14/79 (18%)
		RQC	868..966	CDD:214936	28/167 (17%)
		Sec_Non_Glob	955..>1023	CDD:275213	16/73 (22%)
		HRDC	1025..1090	CDD:278967	10/64 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0514
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D445763at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820