Protein Alignment RecQ5 and WRN

DIOPT Version :10

• Sequence 1: NP_729983.1
• Gene: RecQ5 / 39594
• FlyBaseID: FBgn0027375
• Length: 1058
• Species: Drosophila melanogaster
• Sequence 2: NP_000544.2
• Gene: WRN / 7486
• HGNCID: 12791
• Length: 1432
• Species: Homo sapiens
• Alignment Length: 885
• Identity: 239/885 - (27%)
• Similarity: 382/885 - (43%)
• Gaps: 180/885 - (20%)

  Fly    11 LKKHFGHSKFKSDLQEKAVKCAVKKKQDVYVSMPTGSGKSLCFQLPGLMSENQITIVFSPLLALI 75
            ||.:||||.|| .:|.|.:...:::::|....|.||.|||||||.|.:. ..:|.:|.|||::|:
Human   540 LKMYFGHSSFK-PVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVY-VGKIGLVISPLISLM 602

  Fly    76 KDQIDHLTKLKVPADSLNSKMSTKERDRVIMDLKAVRTNLKFLYITPEQAATKFFQDLLQTLHKH 140
            :||:..|....:||..|.|..|    :.|:.|:|..:  .:.:|:|||..:..  ..|||.|...
Human   603 EDQVLQLKMSNIPACFLGSAQS----ENVLTDIKLGK--YRIVYVTPEYCSGN--MGLLQQLEAD 659

  Fly   141 NKLAYFAVDEAHCVSQWGHDFRPDYLKLGELRSKYSDVIWLALTATASREVKEDIYKQLRLHQPV 205
            ..:...|||||||:|:||||||..:.|||.|::....|..:|||||||..::|||.:.|.|..|
Human   660 IGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNP- 723

  Fly   206 AQFSTPSF-RKNLFYDIVYK--NSIEDDFQHLADFARHCLGNPKEFKDTPKPQRGCGIVYCRTRD 267
             |.:...| |.||:.::..|  |.::|....|...:.|.     ||:       |..|:||.:|.
Human   724 -QITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHW-----EFE-------GPTIIYCPSRK 775

  Fly   268 QVERMAIGVTKQGIGAVAYHAGLKTGERTEVQEAWMRGDQPIICATNSFGMGVDKPSVRFVIHWD 332
            ..:::...:.|..:....||||:....|.::...::|.:...:.||.:||||::|..:|.|||:.
Human   776 MTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYG 840

  Fly   333 VPQNVAAYYQESGRAGRDGLQSYCRLYYGREDVRSIRFLLQNDAHRARGRGDKELLTER----AI 393
            .|:::.:||||.||||||||||.|.:.:...|:...|.||            .|:..|:    .:
Human   841 APKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLL------------TEIRNEKFRLYKL 893

  Fly   394 KQFEKITEFCERTTCRHKLFSDFFGDP-----------TPDCSGQCDVCKRPKKAEKALEIFHRL 447
            |...|:.::...:.||.::....|.|.           |..|   ||.|:.        .:.|..
Human   894 KMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKC---CDNCRS--------RLDHCY 947

  Fly   448 CMDD-----------AFKSHISLQDCADLYEGGRPGIKRAAQEYAGGESGSDDDSGQSHSSMAKR 501
            .|||           |||    |....|:. |.:.||........|..|....|..:.| |:...
Human   948 SMDDSEDTSWDFGPQAFK----LLSAVDIL-GEKFGIGLPILFLRGSNSQRLADQYRRH-SLFGT 1006

  Fly   502 AKKESQDFIKQQFNLRKQISAARQLEQE-TIAQISR----VRMAEATEKKIAGLQATHREKYLTA 561
            .|.:::.:.|         :.:|||..| .:.::||    :::...|:|....|...:.|.  .:
Human  1007 GKDQTESWWK---------AFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTES--QS 1060

  Fly   562 LIDALKANVDKCKDEPGQQPKSVLKYNDYEAMSVNMEYDVFRQNKVANMYRHALVKEISTIKKLT 626
            ||  |:||.:.|       ||.:|..:.....|...|:          .|....| |:||.||..
Human  1061 LI--LQANEELC-------PKKLLLPSSKTVSSGTKEH----------CYNQVPV-ELSTEKKSN 1105

  Fly   627 EQTKLLPLLVDYIPKPETSSKGAWTGGSVAYFERKLKELEEQRPQSLKEVPKALKDRKGFKQENS 691
                 |..|..|.|..:.||     |.:::     .|.:..|.|:               |..:|
Human  1106 -----LEKLYSYKPCDKISS-----GSNIS-----KKSIMVQSPE---------------KAYSS 1140

  Fly   692 KQTSISSFFKKEIKEEPIDSPIQEERVNIKSEQMDLEESTPKDIASNHVKEESVTPESSSSDREL 756
            .|..||:      :|:.....:..:.|..:.:..:..:..|..:|:|.:..:..
Human  1141 SQPVISA------QEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMA----------- 1188

  Fly   757 ELQPDSIIGERKFKLMSNGDGSYDTHRRKRVSHETQPKEKESIKTKSSMQHLFGSFKSESEESNQ 821
            :::|.::...::...:|.|..:......:.:.|..|        |.|....||.|.|.: ||...
Human  1189 KMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQ--------TNSVQTDLFSSTKPQ-EEQKT 1244

  Fly   822 SL---NGFKTARQMLEENNSKLEGVPEKLPIKD-GEKRVL 857
            ||   |...|..|.:....|..:  .:|:|:|. .|.|:|
Human  1245 SLVAKNKICTLSQSMAITYSLFQ--EKKMPLKSIAESRIL 1282

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RecQ5	NP_729983.1	RecQ	5..447	CDD:440280	148/453 (33%)
		SMC_N	658..>963	CDD:481474	38/204 (19%)
WRN	NP_000544.2	Interaction with WRNIP1. /evidence=ECO:0000250|UniProtKB:O09053	2..277
		KBM 1. /evidence=ECO:0000305|PubMed:27063109	11..23
		RNaseD_like	61..229	CDD:176650
		PTZ00341	<156..480	CDD:173534
		2 X 27 AA tandem repeats of H-L-S-P-N-D-N-E-N-D-T-S-Y-V-I-E-S-D-E-D-L-E-M-E-M-L-K	424..477
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	498..529
		recQ_fam	538..1010	CDD:129701	165/522 (32%)
		DEAH box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541	668..671		2/2 (100%)
		Interaction with DNA. /evidence=ECO:0000269|PubMed:20159463	987..993		2/5 (40%)
		HRDC	1156..1229	CDD:128635	11/91 (12%)
		HTH_40	1258..1352	CDD:464189	7/27 (26%)
		KBM 2. /evidence=ECO:0000305|PubMed:27063109	1403..1412
		XLM. /evidence=ECO:0000305|PubMed:27063109	1419..1432