DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RecQ5 and blm

DIOPT Version :9

Sequence 1:	NP_729983.1	Gene:	RecQ5 / 39594	FlyBaseID:	FBgn0027375	Length:	1058	Species:	Drosophila melanogaster
Sequence 2:	XP_017207538.1	Gene:	blm / 572540	ZFINID:	ZDB-GENE-070702-5	Length:	1450	Species:	Danio rerio

Alignment Length:	779	Identity:	239/779 - (30%)
Similarity:	346/779 - (44%)	Gaps:	159/779 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 HESAVHEALKKHFGHSKFKSDLQEKAVKCAVKKKQDVYVSMPTGSGKSLCFQLPGLMSENQITIV 67
            |...:.:...|.||..:|:.: |.:|:..:: ..:|.:|.||||.|||||:|||..:|.. :|:|
Zfish   673 HSPEMMKIFHKKFGLHQFRFN-QLEAINASL-LGEDTFVLMPTGGGKSLCYQLPACVSAG-VTVV 734

  Fly    68 FSPLLALIKDQIDHLTKLKVPADSLNSKMSTKERDRVIMDLKAVRTNLKFLYITPEQ-AATKFFQ 131
            .|||.:||.||:..||.|.:.|.||:......|..|:.|.|......:|.||.|||: .|:....
Zfish   735 ISPLRSLIVDQVQKLTTLDICATSLSGDKKDSEAARIYMQLSRKDPAIKLLYATPEKVCASGRMI 799

  Fly   132 DLLQTLHKHNKLAYFAVDEAHCVSQWGHDFRPDYLKLGELRSKYSDVIWLALTATASREVKEDIY 196
            ..||.|::...||...:|||||||||||||||||.:|.|||..:.:|..:||||||:..|::||.
Zfish   800 SALQNLYERGLLARLVIDEAHCVSQWGHDFRPDYKRLHELRRMFPNVPIMALTATATPRVQKDIL 864

  Fly   197 KQLRLHQPVAQFSTPSF-RKNLFYDIVYKNSIEDDFQHLADFARHCLGNPKEFKDTPKPQRGCGI 260
            .||.:.:|  |..|.|| |.||.|.::.|...:.|        ..|:...|::.     .|..||
Zfish   865 NQLAMTRP--QVFTMSFNRNNLKYSVLPKKPKKVD--------EECIQWIKKYY-----PRDSGI 914

  Fly   261 VYCRTRDQVERMAIGVTKQGIGAVAYHAGLKTGERTEVQEAWMRGDQ-PIICATNSFGMGVDKPS 324
            |||.:|:..:.:|..:.:.||.|:||||||...:|..||..|:..|. .::|||.:||||:|||.
Zfish   915 VYCLSRNDCDTLADSLQRAGIAALAYHAGLSDSDREYVQNKWINQDGCQVMCATIAFGMGIDKPD 979

  Fly   325 VRFVIHWDVPQNVAAYYQESGRAGRDGLQSYCRLYYGREDVRSIRFLLQNDAHRARGRGDKELLT 389
            ||:|||..:|::|..||||||||||||..|:|.|:|...||..|:.|:..|..     |:::...
Zfish   980 VRYVIHASLPKSVEGYYQESGRAGRDGEISHCVLFYSYSDVIRIKRLIAMDKD-----GNQQSKA 1039

  Fly   390 ERAIKQFEKITEFCERTT-CRHKLFSDFFGDPT---------PDCSGQCDVCKRPKKAEKALEIF 444
            .. |.....:..|||... ||......:||:.|         |:..  ||.|.||.|.:.
Zfish  1040 TH-INNLHSMVHFCENVAECRRIQLLAYFGEHTFNTSFCKEHPEVI--CDNCARPNKYKS----- 1096

  Fly   445 HRLCMDDAFKSHISLQD-CADLYEGGRPGIKRAAQE-----------YAGGESGSDDDS----GQ 493
             |...||..|....:|| |..:  |.|.|  ::||:           :.|.:|......    |.
Zfish  1097 -RNVTDDVKKIARFVQDNCEKV--GNRYG--KSAQQNRLTLNMLVEIFLGSKSARIQTGMFGVGA 1156

  Fly   494 SHSS-MAKRAKKE-------SQD-FIKQQFNLRKQISAARQLEQETIAQISRVRMAEATEKKIAG 549
            ::|. .|:|..|:       .:| :|.........|||.    .:.::.::.....|..|.:.|.
Zfish  1157 AYSKHNAERLFKKLVLDNVLMEDLYITNSGQAVAYISAG----PKAMSVLNGCMQVEFHETESAS 1217

  Fly   550 LQATHR----EKYLTALIDALKANVDKCKDEPGQQPKSVLKYNDYEAMSVNMEYDVFRQNKVANM 610
            ....||    ||     :...:..|.||..|.....|.:.|     ...::. |::|
Zfish  1218 SIRKHRASVCEK-----VSKREEMVKKCLGELNDLCKKLGK-----VFGIHY-YNIF-------- 1263

  Fly   611 YRHALVKEISTIKKLTE----------------QTKL-------LPLLVDY----IPKPETSSKG 648
                   ..:|:||:.|                :.||       :.||..|    :|....:...
Zfish  1264 -------STATLKKIAETLSADPEVLLQIDGVTEDKLEKYGAEFIELLQKYSEWQLPAEAQAESS 1321

  Fly   649 AWT-------------------GGSV--AYFERKLKELEEQRPQSLKEVPKALKDRKGFKQENS 691
            .|.                   ||.|  .||........:::..|....||.   |||...:||
Zfish  1322 GWIDTTRGHQNDEDDNDDDDEGGGDVTSTYFRSNSGRGAKRKQGSYSRKPKR---RKGSSGQNS 1382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RecQ5	NP_729983.1	RecQ	6..>442	CDD:223588	175/448 (39%)
		DEAD	37..193	CDD:278688	75/156 (48%)
		HELICc	<257..359	CDD:238034	52/102 (51%)
		RecQ_Zn_bind	364..431	CDD:292742	18/76 (24%)
blm	XP_017207538.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0514
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D445763at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820