DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RecQ5 and recql5

DIOPT Version :9

Sequence 1:	NP_729983.1	Gene:	RecQ5 / 39594	FlyBaseID:	FBgn0027375	Length:	1058	Species:	Drosophila melanogaster
Sequence 2:	XP_005164331.1	Gene:	recql5 / 566553	ZFINID:	ZDB-GENE-071214-1	Length:	933	Species:	Danio rerio

Alignment Length:	1067	Identity:	361/1067 - (33%)
Similarity:	537/1067 - (50%)	Gaps:	224/1067 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SAVHEALKKHFGHSKFKSDLQEKAVKCAVKKKQDVYVSMPTGSGKSLCFQLPGLMSENQITIVFS 69
            |.||.|||.|||..||:|..||:||...::..:||:|.||||:|||||:|||.||:.. :|:|.|
Zfish     2 SVVHRALKTHFGFEKFRSRQQEEAVNALLQGDRDVFVCMPTGAGKSLCYQLPALMASG-VTLVIS 65

  Fly    70 PLLALIKDQIDHLTKLKVPADSLNSKMSTKERDRVIMDLKAVRTNLKFLYITPEQAATKFFQDLL 134
            ||:|||:||::||..|.|||.|:|||:...||.:::.||::....||.||||||..|:..||.:|
Zfish    66 PLIALIQDQVEHLKALNVPARSINSKLPLAERRQILADLESETPRLKLLYITPEMVASPSFQPVL 130

  Fly   135 QTLHKHNKLAYFAVDEAHCVSQWGHDFRPDYLKLGELRSKYSDVIWLALTATASREVKEDIYKQL 199
            .:|.....|.|.|||||||||||||||||||||||:|||:...:..:||||||.:.|||||.:.|
Zfish   131 SSLSSRGLLGYLAVDEAHCVSQWGHDFRPDYLKLGDLRSRLQGIRCIALTATAPKRVKEDIERSL 195

  Fly   200 RLHQPVAQFSTPSFRKNLFYDIVYKNSIEDDFQHLADFARHCL-GNPKEFKDTPKPQRGCGIVYC 263
            ||..|:. ||||.|||||.||:::::.:.:.:.||..||:..| ||..|        :|||||||
Zfish   196 RLRSPLV-FSTPVFRKNLKYDVIFRDLLPEPYVHLLAFAKEALGGNTAE--------KGCGIVYC 251

  Fly   264 RTRDQVERMAIGVTKQGIGAVAYHAGLKTGERTEVQEAWMRGDQPIICATNSFGMGVDKPSVRFV 328
            |||:..|.:|..:||.||.|..||||||:|:|:|.|..||....|||.||.||||||||.:||||
Zfish   252 RTRESCEEVAHKLTKLGIAAKPYHAGLKSGDRSENQADWMADKVPIIVATISFGMGVDKANVRFV 316

  Fly   329 IHWDVPQNVAAYYQESGRAGRDGLQSYCRLYYGREDVRSIRFLLQNDAHRAR-GRGDKELLTERA 392
            :||::.:::|:|||||||||||||.|.||:||..:|...:.||::.:..|.: .||.::...:..
Zfish   317 VHWNLAKSLASYYQESGRAGRDGLPSSCRIYYSPKDRDQLNFLIRKEISRKQEKRGSEKEQDKAP 381

  Fly   393 IKQFEKITEFCERTTCRHKLFSDFFGDPTPDCSGQCDVCKRPKKAEKALEIFHRLCMDDAFKSHI 457
            |..||.:..|||:..|||...|.|||:..|:|:|.||.|:.||....      :|....|..:..
Zfish   382 ILDFEAMVAFCEQEGCRHATISTFFGNEKPNCAGACDFCRDPKLVRA------QLARAAALSTRT 440

  Fly   458 SLQDCA----------DLYEGGRP--GIKRAAQEYAGGESGSDDDSGQSHSSMAKRAKKESQDFI 510
            :....|          :||.|||.  |.:|..:||     ||::|.       :::.||:..|..
Zfish   441 NPTHSAEPRGPFGFDPELYAGGRKGYGFERHDEEY-----GSEEDD-------SEKRKKQFGDLF 493

  Fly   511 KQQFNLRKQISAARQLEQET-IAQISRVRMAEATEKKIAGLQATHREKYLTALIDALKANVDKCK 574
            |:|.:|||...|.:    || :...:...:.:|:.::|..|....||..|:.|.:.|.::....:
Zfish   494 KKQMSLRKGSDAPK----ETFVPPDADCVLKDASSQRIPRLTVKSREHCLSLLQECLSSHSGDAE 554

  Fly   575 DEPGQQPKSVLKYNDYEAMSVNMEYDVFRQNKVANMYRHALVKEISTIKKLTEQTKLLPLLVDYI 639
                     .|..::....:|::|:::|:.:|.||:|:.|::|.:|.:||.|
Zfish   555 ---------FLHRSEALDQAVDIEHEIFKSSKSANIYKAAVLKRVSEMKKST------------- 597

  Fly   640 PKPETSSKGAWTGGSVAYFERKLKELEEQRP------QSLKEVPKA-----LKDRK---GFKQEN 690
                          ||:..|.|..|..|::|      |.|.....|     ||.::   ||:
Zfish   598 --------------SVSVTEEKPCESAEEKPTCSSSAQHLDGFTSASQIYSLKRKRVGAGFR--- 645

  Fly   691 SKQTSISSFFK------KEIKEEPIDSPIQEERVNIKSEQMDLEESTPKDIASNHVKEESVTPES 749
                ..||.|:      |...:.|.||..:||           ...|.||  :|:.........|
Zfish   646 ----GSSSLFQPAGDLLKSSDQTPGDSTCEEE-----------SGKTQKD--NNNTSSIKAKSGS 693

  Fly   750 SSSDRELELQPDSIIGERKFKLMSNGDGSYDTH------RRKRVSHETQPKEKESIKTKSSMQHL 808
            |||..    .|...:..::.||   .:.:.||.      .:|:...|:.|:.:|:
Zfish   694 SSSLN----SPSKKLSRKQQKL---AEAARDTRLISLYFGKKQAQRESSPEPEET---------- 741

  Fly   809 FGSFKSESEESNQSLNGFKTARQMLEENNSKLEGVPEKLPIKDGEKRVLENRADSIGFTSAREML 873
                :...|:.:.|.||..|.      ::|.:          |.|:...|:..:   .|:..|..
Zfish   742 ----EDACEDRSASANGVHTL------SSSSV----------DAERAAQESLCE---VTAHAEDY 783

  Fly   874 ERSKQREGDDKSSNKLEKLGFISAREMLEKNKLNERCLDKKDVK------EKKLESRETKRSLQN 932
            ..::|.:|..||..:..:                    |:.:|:      :::...::|||...:
Zfish   784 GENQQSDGQRKSPKQAHE--------------------DRSEVRAPSPPVKRRRVLKDTKRVTFD 828

  Fly   933 NELQHKQEEDRKDKASHRKTSKESLSNLKKEGSD-SRVLQKDTKPETRNHQKTDVSKNVVQWLNP 996
            ..:|..|.|                 .|..:|:. ||      ||.|.. :..|:   ||:.|:|
Zfish   829 PVVQETQVE-----------------ALNGDGAGISR------KPVTLK-EAADI---VVRCLDP 866

  Fly   997 YYKR-KIATKELFKALAKLLTQRICDG 1022
            :||: |.|||:|||:.|:.|:..:.:|
Zfish   867 FYKQGKFATKDLFKSFARFLSHLLTEG 893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RecQ5	NP_729983.1	RecQ	6..>442	CDD:223588	225/437 (51%)
		DEAD	37..193	CDD:278688	89/155 (57%)
		HELICc	<257..359	CDD:238034	65/101 (64%)
		RecQ_Zn_bind	364..431	CDD:292742	24/67 (36%)
recql5	XP_005164331.1	DEXDc	12..217	CDD:214692	117/206 (57%)
		DEAD	22..189	CDD:278688	93/167 (56%)
		HELICc	211..347	CDD:238034	77/143 (54%)
		RecQ_Zn_bind	352..420	CDD:292742	24/67 (36%)
		RecQ5	629..755	CDD:284397	34/166 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595195
Domainoid	1	1.000	194	1.000	Domainoid score	I3125
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	526	1.000	Inparanoid score	I1201
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D251827at33208
OrthoFinder	1	1.000	-	-		FOG0006219
OrthoInspector	1	1.000	-	-		oto39407
orthoMCL	1	0.900	-	-		OOG6_105167
Panther	1	1.100	-	-	LDO	PTHR13710
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4493
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.900