DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RecQ5 and recql

DIOPT Version :9

Sequence 1:	NP_729983.1	Gene:	RecQ5 / 39594	FlyBaseID:	FBgn0027375	Length:	1058	Species:	Drosophila melanogaster
Sequence 2:	XP_005164818.1	Gene:	recql / 566018	ZFINID:	ZDB-GENE-050809-134	Length:	798	Species:	Danio rerio

Alignment Length:	753	Identity:	202/753 - (26%)
Similarity:	332/753 - (44%)	Gaps:	154/753 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 FGHSKFKSDLQEKAVKCAVKKKQDVYVSMPTGSGKSLCFQLPGLMSENQITIVFSPLLALIKDQI 79
            |..|||: .||..|:..::..| |:::.||||.|||||:|||.|.|:. .|:|.:||::|::||:
Zfish    93 FQLSKFR-PLQRAAINLSMSGK-DLFLVMPTGRGKSLCYQLPALCSKG-FTLVIAPLVSLMEDQL 154

  Fly    80 DHLTKLKVPADSLNSKMSTKERDRVIMDLKAVRTNLKFLYITPEQ-AATKFFQDLLQTLHKHNKL 143
            .:|..:.|||.:||:..|.::..|::..:....:..|.||:|||: |.:|.....|:.......|
Zfish   155 MYLQSVNVPAVTLNASSSKEDSKRILAGMTDKNSPFKLLYVTPEKIAKSKLLMSKLEKAFNMGLL 219

  Fly   144 AYFAVDEAHCVSQWGHDFRPDYLKLGELRSKYSDVIWLALTATASREVKEDIYKQLRLHQPVAQF 208
            |..||||.||.|||||||||||..||.|:.::.:|..:.|||||:..|.:|..|.|.:.:||. .
Zfish   220 ARIAVDEVHCCSQWGHDFRPDYKLLGILKRQFPNVPLIGLTATATSNVLKDCQKILCVQEPVT-L 283

  Fly   209 STPSFRKNLFYDIVYKNSIEDDFQHLADFARHCLGNPKEFKDTPKPQRGCGIVYCRTRDQVERMA 273
            :.|..|.||:|::.:|:: ||....:|...|....|..            ||||..::...|.:|
Zfish   284 TAPFNRPNLYYEVRFKDN-EDCTDQIASLIRGRYKNQS------------GIVYVFSQKDAEVVA 335

  Fly   274 IGVTKQGIGAVAYHAGLKTGERTEVQEAWMRGDQPIICATNSFGMGVDKPSVRFVIHWDVPQNVA 338
            ..:.|:.|.|..|||.::...::.|.:.|......::.||.:||||:||..||||||..:.:::.
Zfish   336 TELQKRDIVAQPYHANMEPSHKSLVHQRWSSKKIQVVVATVAFGMGIDKADVRFVIHHTISKSIE 400

  Fly   339 AYYQESGRAGRDGLQSYCRLYYGREDVRSIRFLLQNDAHRARGRGDKELLTERAIKQFEKITEFC 403
            .|||||||||||...:.|.:::|..|:..|..::              ::.....::...:..:|
Zfish   401 NYYQESGRAGRDDSPADCIVFFGFMDIFRISTMV--------------VMENTGQQKLHNMVAYC 451

  Fly   404 ERT-TCRHKLFSDFFGDPTPD--CSGQCDVCKRPKK------AEKALEIFHRLCMDDAFKSHISL 459
            :.. .||..:.:..|.:...|  |:..||||:....      .:.|.::.|.:.:..:....::.
Zfish   452 QNVDRCRRAMMAIHFDEVWNDEECNEMCDVCRHGNDYITMDITQHARDVLHIVELASSMDEKLTP 516

  Fly   460 QDCADLYEGGRPGIKRA-------------------------AQEYA------------GGESGS 487
            ....|.:.|..|..:|.                         :::::            |.::..
Zfish   517 LKVCDAWLGKGPAKQRKMIKLTSLSRLEVESVIIHLLLHGYFSEDFSFTPYTTHFYLKLGRKAAL 581

  Fly   488 DDDSGQSHS-SMAKRAKKESQD--------FI----------------KQQFNLRKQISAARQLE 527
            ..:||.|.: .|.:|...:|.|        ||                |...|:.|::|   |..
Zfish   582 LKNSGHSITMKMRRRGTSQSTDVHDDIETAFIDESNMAVQRCKKTKIHKNHQNMEKRLS---QNH 643

  Fly   528 QETIA-----------------QISRVRMAEATEKKIAGLQATH---------REKYLTA-LIDA 565
            .|::|                 :::.|.....|.:...||::||         |:|...| .:|.
Zfish   644 TESLASEASEYIKPTSVFEVDVEVNHVEEQNCTSQDENGLESTHEQQQSPLKKRQKQNCAPNVDQ 708

  Fly   566 LKANVDKCKDEPGQQPKSVLKYNDYEAMSVNMEY---DVFRQNKVANMYRHALVKEISTIKKLTE 627
            .|.|::....|     .|::.....|.:.....|   .:.|.|.|:  :.|........:..:.|
Zfish   709 AKVNLESAPSE-----LSIISAAAVEELHHLRSYYSKQLRRINYVS--HEHLQSSRPGMLTCMKE 766

  Fly   628 QTKLLPLLVDYIPKPETSSKGA---WTGGSVAYFERKL 662
            ..|.|     ..|...|.:|||   ||..|:   .|||
Zfish   767 PFKSL-----RFPSRSTLTKGARNLWTRVSM---RRKL 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RecQ5	NP_729983.1	RecQ	6..>442	CDD:223588	146/436 (33%)
		DEAD	37..193	CDD:278688	68/156 (44%)
		HELICc	<257..359	CDD:238034	40/101 (40%)
		RecQ_Zn_bind	364..431	CDD:292742	10/69 (14%)
recql	XP_005164818.1	DEXDc	89..542	CDD:331760	151/479 (32%)
recql	XP_005164818.1	GTP_EFTU	599..>734	CDD:332590	26/142 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D445763at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920