DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RecQ5 and Blm

DIOPT Version :9

Sequence 1:	NP_729983.1	Gene:	RecQ5 / 39594	FlyBaseID:	FBgn0027375	Length:	1058	Species:	Drosophila melanogaster
Sequence 2:	NP_524319.2	Gene:	Blm / 41366	FlyBaseID:	FBgn0002906	Length:	1487	Species:	Drosophila melanogaster

Alignment Length:	884	Identity:	250/884 - (28%)
Similarity:	386/884 - (43%)	Gaps:	189/884 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 HESAVHEALKKHFGHSKFK-SDLQEKAVKCAVKKKQDVYVSMPTGSGKSLCFQLPGLMSENQITI 66
            |.:.:...|...||...|: :.||   |..|.....|.:|.||||.|||||:|||.:::|. :||
  Fly   721 HSTRLMHGLSYSFGLKSFRPNQLQ---VINATLLGNDCFVLMPTGGGKSLCYQLPAILTEG-VTI 781

  Fly    67 VFSPLLALIKDQIDHLTKLKVPADSLNSKMSTKERDRVIMDLKAVRTNLKFLYITPEQ-AATKFF 130
            |.|||.:||.|||:.|..|.:.|.||:.:....:...:..||::....:|.||:|||: :::..|
  Fly   782 VISPLKSLIFDQINKLASLDICAKSLSGEQKMADVMAIYRDLESQPPMVKLLYVTPEKISSSARF 846

  Fly   131 QDLLQTLHKHNKLAYFAVDEAHCVSQWGHDFRPDYLKLGELRSKYSDVIWLALTATASREVKEDI 195
            ||.|.||:.:|.::.|.:|||||||||||||||||.|||.|:.::.:|..:||||||:..|:.||
  Fly   847 QDTLDTLNSNNYISRFVIDEAHCVSQWGHDFRPDYKKLGVLKKRFPNVPTIALTATATPRVRLDI 911

  Fly   196 YKQLRLHQPVAQFSTPSF-RKNLFYDIVYKNSIEDDFQHLADFARHCLGNPKEFKDTPKPQRGCG 259
            ..||.|..  .::...|| |.||.|.::.|..:..    |.|.:|:....|:.|.         |
  Fly   912 LAQLNLKN--CKWFLSSFNRSNLRYRVLPKKGVST----LDDISRYIRSKPQHFS---------G 961

  Fly   260 IVYCRTRDQVERMAIGVTKQGIGAVAYHAGLKTGERTEVQEAWMRGDQPIICATNSFGMGVDKPS 324
            |:||.:|.:.:..:..:.|.|:.||:|||||...:|...|:.|:.|...:||||.:||||:|||.
  Fly   962 IIYCLSRKECDETSKKMCKDGVRAVSYHAGLTDTDRESRQKDWLTGKMRVICATVAFGMGIDKPD 1026

  Fly   325 VRFVIHWDVPQNVAAYYQESGRAGRDGLQSYCRLYYGREDVRSIRFLLQNDAHRARGRGDKELLT 389
            ||||:|:.:|:::..||||:|||||||..:.|.|||...|:..|:.:|.:|  :|.....|::
  Fly  1027 VRFVLHYSLPKSIEGYYQEAGRAGRDGDVADCILYYNYSDMLRIKKMLDSD--KALQYNVKKI-- 1087

  Fly   390 ERAIKQFEKITEFCER-TTCRHKLFSDFFGD--PTPDC----SGQCDVC--KRPKKAEKALEIFH 445
              .:....:|..:||. |.||.....|:||:  .:..|    ...||.|  ||..||..|||...
  Fly  1088 --HVDNLYRIVGYCENLTDCRRAQQLDYFGEHFTSEQCLENRETACDNCINKRAYKAVDALEHAR 1150

  Fly   446 R-------LCMDDAFKSHISLQDCADLYEGGRPGIKRAA--QEYAGGESG--SDDDSGQSHSSMA 499
            :       ||   :.:|..:|...||:.:|.:  ||:..  ..:.....|  .|.|....|..:.
  Fly  1151 KAARAVKDLC---SGRSRFTLLHIADVLKGSK--IKKIIDFNHHKTPHHGVLKDWDKNDVHRLLR 1210

  Fly   500 KRA-----KKE---SQDFIKQQFNLRKQIS-----------AARQLEQETIAQISRVR--MAEAT 543
            |..     :::   :.||.:....|...||           |..:..:|..|.:..|.  ...:|
  Fly  1211 KMVIDGFLREDLIFTNDFPQAYLYLGNNISKLMEGTPNFEFAVTKNAKEAKAAVGSVSDGATSST 1275

  Fly   544 EKKIAGLQATHREKYLTALIDALKANVDKCKDEPGQQPKSVLKYNDYEAMSVNMEYDVFRQNKVA 608
            ....:|::..|...|...|        |.|:....|
  Fly  1276 ADGQSGMREIHERCYTDLL--------DLCRTIASQ----------------------------- 1303

  Fly   609 NMYRHALVKEISTIKKLTEQTKLLPLLVDYIPKPETSSKGAWTGGSVAYFERKLKELEEQRPQSL 673
               |:..:..|..|:.|....:.||                               :.|:...|:
  Fly  1304 ---RNVTMASIMNIQALKSMAETLP-------------------------------ITEKDMCSI 1334

  Fly   674 KEVPKALKDRKGFKQENSKQTSISSFFKKE--IKEEPIDSPIQEERVNIKSEQMDL---EESTPK 733
            ..|.||..|:.|     :|...|:|.:..|  :.:..:|.  :||:...|......   .||...
  Fly  1335 PHVTKANFDKYG-----AKLLEITSNYASEKLLMQAVLDE--EEEQAAAKQRPSTSGWNNESVDW 1392

  Fly   734 DIASNHVKEESVTPESSSSDRELELQPDSIIGERKFKLMSNGDGSYDTHRRKRV-------SHET 791
            |:|   |..:.....|.:|                      |..|:...:||::       .::|
  Fly  1393 DMA---VASQGNANTSGAS----------------------GFNSFRAGKRKKIYKSGASKRYKT 1432

  Fly   792 QPKEKESIKTKSSMQHLFGSFKSESEESNQSLNGFKTAR 830
            ......:.||.|:......:....:|.|..|.:|:|:.:
  Fly  1433 STTSPAARKTTSARGRGGRAGAKRAESSASSASGWKSKK 1471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RecQ5	NP_729983.1	RecQ	6..>442	CDD:223588	175/447 (39%)
		DEAD	37..193	CDD:278688	76/156 (49%)
		HELICc	<257..359	CDD:238034	47/101 (47%)
		RecQ_Zn_bind	364..431	CDD:292742	18/73 (25%)
Blm	NP_524319.2	RQC	1140..1253	CDD:286470	24/117 (21%)
		HRDC	1286..1352	CDD:278967	20/141 (14%)
		RecQ	729..1359	CDD:223588	224/735 (30%)
		DEAD	739..908	CDD:278688	79/172 (46%)
		HELICc	931..1061	CDD:238034	56/142 (39%)
		RecQ_Zn_bind	1066..1134	CDD:292742	18/73 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457826
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0514
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D445763at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR13710
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R580
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.880