DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RecQ5 and Wrn

DIOPT Version :9

Sequence 1:	NP_729983.1	Gene:	RecQ5 / 39594	FlyBaseID:	FBgn0027375	Length:	1058	Species:	Drosophila melanogaster
Sequence 2:	XP_006253318.1	Gene:	Wrn / 290805	RGDID:	1564788	Length:	1400	Species:	Rattus norvegicus

Alignment Length:	1058	Identity:	265/1058 - (25%)
Similarity:	430/1058 - (40%)	Gaps:	268/1058 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LKKHFGHSKFKSDLQEKAVKCAVKKKQDVYVSMPTGSGKSLCFQLPGLMSENQITIVFSPLLALI 75
            ||.:|||..|| .:|.|.:...:::::|..|.|.||.|||||||.|.:.: .:|.||.|||::|:
  Rat   504 LKTYFGHCSFK-PVQWKVIHSVLEERRDNVVVMATGYGKSLCFQYPPVYT-GKIGIVISPLISLM 566

  Fly    76 KDQIDHLTKLKVPADSLNSKMSTKERDRVIMDLKAVRTNLKFLYITPEQAATKFFQDLLQTLHKH 140
            :||:..|....:||..|.|    .:...::.|:|..|  .:.:|||||..:...  ||||.|..:
  Rat   567 EDQVLQLEMSNIPACLLGS----AQPKNILGDIKLGR--YRIIYITPEFCSGNL--DLLQQLDSN 623

  Fly   141 NKLAYFAVDEAHCVSQWGHDFRPDYLKLGELRSKYSDVIWLALTATASREVKEDIYKQLRLHQPV 205
            ..:...|||||||:|:||||||..:..||.|::....|..:||:||||..::|||.:.|.|..|
  Rat   624 IGITLIAVDEAHCISEWGHDFRSSFRTLGSLKTALPLVPVIALSATASSSIREDIIRCLNLKDP- 687

  Fly   206 AQFSTPSF-RKNLFYDIVYK--NSIEDDFQHLADFARHCLGNPKEFKDTPKPQRGCGIVYCRTRD 267
             ..:...| |.||:.::..|  |.::|    |..|......:..||:       |..|:||.:|.
  Rat   688 -HITCTGFDRPNLYLEVERKTGNILQD----LKPFLVRKTSSAWEFE-------GPTIIYCPSRK 740

  Fly   268 QVERMAIGVTKQGIGAVAYHAGLKTGERTEVQEAWMRGDQPIICATNSFGMGVDKPSVRFVIHWD 332
            ..|::.:.:.|..:...|||||:|..||.::...::|.:...:.||.:||||::|..:|.|||:.
  Rat   741 VTEQVTVELGKLNVACQAYHAGMKISERKDIHHRFLRDEIQCVVATIAFGMGINKADIRKVIHYG 805

  Fly   333 VPQNVAAYYQESGRAGRDGLQSYCRLYYGREDVRSIRFLLQNDAHRARGRGDKELLTERAIKQFE 397
            .|:.:.:||||.||||||||||.|.|.:...|..:.|..| .:.|..:.|..|       :|...
  Rat   806 APKEMESYYQEIGRAGRDGLQSSCHLLWAPADFNTTRNRL-IEIHNEKFRLHK-------LKMMV 862

  Fly   398 KITEFCERTTCRHKLFSDFFGDPTPDCSGQCDVCKRPKKAEKALEIFHRLCMDDAFKSHISLQDC 462
            |:.::...:.||.::....|.|            ||.:||..|:               :..:.|
  Rat   863 KMEKYLHSSRCRRQIILSHFED------------KRLQKASLAV---------------MGTEKC 900

  Fly   463 ADLYEGGRPGIKRAAQEYAGGESGSDDDSGQSHSSMAKRAKKESQDFIKQQFNLRKQISAARQLE 527
            .|   ..||.:                    :|.|.|..::..:|||..|.|.|   :||...|:
  Rat   901 CD---NCRPRL--------------------NHCSSANNSEDTAQDFGPQAFQL---LSAVDILQ 939

  Fly   528 QETIAQISRVRMAEATEKKIAGLQATHR----------------EKYLTA---LIDALKAN--VD 571
            ::...:|..:.:..:..:::......||                ..:|.|   |::..|.|  :.
  Rat   940 EKFGIKIPILFLRGSNSQRLPEKYHNHRLFGAGKEQAESWWKALSHHLIAEGFLVEVPKQNKFIK 1004

  Fly   572 KCK-DEPG---------QQPKSVLKYNDYEAMSVNMEYDVFRQNKVANMYRHALVKEISTIKKLT 626
            .|. .:.|         |.|.|::...|.||.|                 |.||:...:.:...|
  Rat  1005 TCSLTKKGRKWLGEAILQSPPSLVLQADEEAFS-----------------RKALLSSSNPVSSET 1052

  Fly   627 EQTKLLPLLVDYIPKPETSSKGAWTGGSV--AYFERKLKELEEQRPQSLKEVPKALKDRKGFKQE 689
                          ||.:|::.. ||.|.  :..|....:...::..|...:||     |....:
  Rat  1053 --------------KPHSSNQKP-TGSSTQQSNLEGAYSDKVPEKFSSGSNIPK-----KSVVMQ 1097

  Fly   690 NSKQTSISSFFKKEIKEEPIDSPIQEERVNIKSEQMD--------LEESTPKDIASNHVKEESVT 746
             |..||.||:       ||:          |.::::|        |.|:..|     |..|..|.
  Rat  1098 -SPGTSYSSW-------EPV----------ISAQEVDTRTVLYARLVEARQK-----HANEVDVP 1139

  Fly   747 PESSSSDREL----ELQPDSIIGERKFKLMSNGDGSYDTHRRKRVSHETQPKEKESIKTKSSMQH 807
            |...::::.|    :::|.::...::...:|.|..:......:.:.|..|   ..|::|     .
  Rat  1140 PAVLATNKVLLDMAKMRPTTVENVKQIDGVSEGKAALLAPLTEVIKHFCQ---VNSVQT-----D 1196

  Fly   808 LFGSFK-SESEESNQSL--------NGFKTARQMLEENNSKLEGVPEK--LP-----------IK 850
            ||.|.| .|.||.:|.:        ........:.:|....|..:.|.  ||           :|
  Rat  1197 LFASTKPQEDEEKSQEMENKACSLPQSAAVTYALFQEKKMSLHSIAENRLLPLTAVGMHLAQAVK 1261

  Fly   851 DGEKRVLENRADSIGFT-SAREMLERSKQREGDDKSSNKLEKLGFISAR-----------EMLEK 903
            .|....:| ||   |.| ..|:::....:....:....|::.:..:...           |:||.
  Rat  1262 AGHPLDME-RA---GLTPETRKIIMDVIRNPPINSDMYKVKLIRMLVPENIDTYLIHMMIEILES 1322

  Fly   904 ----------NKLNERCL------------DKKDVKEKKLESRETKRSLQNNELQHKQEEDRKDK 946
                      :...:|||            .|:.|.|.|..|..::|.|        .|...|..
  Rat  1323 GSHGRTQPSCDSNRKRCLPSPAESCGSFKKSKEMVTETKAPSEMSQRKL--------PEWFVKGN 1379

  Fly   947 ASHRKTSKESLSNLKKEG 964
            .....|...|::..||:|
  Rat  1380 VPLAATGSSSMAKTKKKG 1397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RecQ5	NP_729983.1	RecQ	6..>442	CDD:223588	151/433 (35%)
		DEAD	37..193	CDD:278688	64/155 (41%)
		HELICc	<257..359	CDD:238034	43/101 (43%)
		RecQ_Zn_bind	364..431	CDD:292742	12/66 (18%)
Wrn	XP_006253318.1	RNaseD_like	55..223	CDD:176650
		recQ_fam	502..975	CDD:129701	170/554 (31%)
		DEAD	515..676	CDD:278688	66/169 (39%)
		HELICc	<730..832	CDD:238034	43/101 (43%)
		RecQ_Zn_bind	837..904	CDD:292742	19/104 (18%)
		RQC	923..1016	CDD:214936	18/95 (19%)
		HRDC	1118..1194	CDD:128635	14/83 (17%)
		HTH_40	1226..1316	CDD:291179	14/93 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0514
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D445763at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820