Protein Alignment RecQ5 and Wrn

DIOPT Version :10

• Sequence 1: NP_729983.1
• Gene: RecQ5 / 39594
• FlyBaseID: FBgn0027375
• Length: 1058
• Species: Drosophila melanogaster
• Sequence 2: XP_063131309.1
• Gene: Wrn / 290805
• RGDID: 1564788
• Length: 1431
• Species: Rattus norvegicus
• Alignment Length: 1058
• Identity: 265/1058 - (25%)
• Similarity: 430/1058 - (40%)
• Gaps: 268/1058 - (25%)

  Fly    11 LKKHFGHSKFKSDLQEKAVKCAVKKKQDVYVSMPTGSGKSLCFQLPGLMSENQITIVFSPLLALI 75
            ||.:|||..|| .:|.|.:...:::::|..|.|.||.|||||||.|.:.: .:|.||.|||::|:
  Rat   535 LKTYFGHCSFK-PVQWKVIHSVLEERRDNVVVMATGYGKSLCFQYPPVYT-GKIGIVISPLISLM 597

  Fly    76 KDQIDHLTKLKVPADSLNSKMSTKERDRVIMDLKAVRTNLKFLYITPEQAATKFFQDLLQTLHKH 140
            :||:..|....:||..|.|    .:...::.|:|..|  .:.:|||||..:...  ||||.|..:
  Rat   598 EDQVLQLEMSNIPACLLGS----AQPKNILGDIKLGR--YRIIYITPEFCSGNL--DLLQQLDSN 654

  Fly   141 NKLAYFAVDEAHCVSQWGHDFRPDYLKLGELRSKYSDVIWLALTATASREVKEDIYKQLRLHQPV 205
            ..:...|||||||:|:||||||..:..||.|::....|..:||:||||..::|||.:.|.|..|
  Rat   655 IGITLIAVDEAHCISEWGHDFRSSFRTLGSLKTALPLVPVIALSATASSSIREDIIRCLNLKDP- 718

  Fly   206 AQFSTPSF-RKNLFYDIVYK--NSIEDDFQHLADFARHCLGNPKEFKDTPKPQRGCGIVYCRTRD 267
             ..:...| |.||:.::..|  |.::|    |..|......:..||:       |..|:||.:|.
  Rat   719 -HITCTGFDRPNLYLEVERKTGNILQD----LKPFLVRKTSSAWEFE-------GPTIIYCPSRK 771

  Fly   268 QVERMAIGVTKQGIGAVAYHAGLKTGERTEVQEAWMRGDQPIICATNSFGMGVDKPSVRFVIHWD 332
            ..|::.:.:.|..:...|||||:|..||.::...::|.:...:.||.:||||::|..:|.|||:.
  Rat   772 VTEQVTVELGKLNVACQAYHAGMKISERKDIHHRFLRDEIQCVVATIAFGMGINKADIRKVIHYG 836

  Fly   333 VPQNVAAYYQESGRAGRDGLQSYCRLYYGREDVRSIRFLLQNDAHRARGRGDKELLTERAIKQFE 397
            .|:.:.:||||.||||||||||.|.|.:...|..:.|..| .:.|..:.|..|       :|...
  Rat   837 APKEMESYYQEIGRAGRDGLQSSCHLLWAPADFNTTRNRL-IEIHNEKFRLHK-------LKMMV 893

  Fly   398 KITEFCERTTCRHKLFSDFFGDPTPDCSGQCDVCKRPKKAEKALEIFHRLCMDDAFKSHISLQDC 462
            |:.::...:.||.::....|.|            ||.:||..|:               :..:.|
  Rat   894 KMEKYLHSSRCRRQIILSHFED------------KRLQKASLAV---------------MGTEKC 931

  Fly   463 ADLYEGGRPGIKRAAQEYAGGESGSDDDSGQSHSSMAKRAKKESQDFIKQQFNLRKQISAARQLE 527
            .|   ..||.:                    :|.|.|..::..:|||..|.|.|   :||...|:
  Rat   932 CD---NCRPRL--------------------NHCSSANNSEDTAQDFGPQAFQL---LSAVDILQ 970

  Fly   528 QETIAQISRVRMAEATEKKIAGLQATHR----------------EKYLTA---LIDALKAN--VD 571
            ::...:|..:.:..:..:::......||                ..:|.|   |::..|.|  :.
  Rat   971 EKFGIKIPILFLRGSNSQRLPEKYHNHRLFGAGKEQAESWWKALSHHLIAEGFLVEVPKQNKFIK 1035

  Fly   572 KCK-DEPG---------QQPKSVLKYNDYEAMSVNMEYDVFRQNKVANMYRHALVKEISTIKKLT 626
            .|. .:.|         |.|.|::...|.||.|                 |.||:...:.:...|
  Rat  1036 TCSLTKKGRKWLGEAILQSPPSLVLQADEEAFS-----------------RKALLSSSNPVSSET 1083

  Fly   627 EQTKLLPLLVDYIPKPETSSKGAWTGGSV--AYFERKLKELEEQRPQSLKEVPKALKDRKGFKQE 689
                          ||.:|::.. ||.|.  :..|....:...::..|...:||     |....:
  Rat  1084 --------------KPHSSNQKP-TGSSTQQSNLEGAYSDKVPEKFSSGSNIPK-----KSVVMQ 1128

  Fly   690 NSKQTSISSFFKKEIKEEPIDSPIQEERVNIKSEQMD--------LEESTPKDIASNHVKEESVT 746
             |..||.||:       ||:          |.::::|        |.|:..|     |..|..|.
  Rat  1129 -SPGTSYSSW-------EPV----------ISAQEVDTRTVLYARLVEARQK-----HANEVDVP 1170

  Fly   747 PESSSSDREL----ELQPDSIIGERKFKLMSNGDGSYDTHRRKRVSHETQPKEKESIKTKSSMQH 807
            |...::::.|    :::|.::...::...:|.|..:......:.:.|..|   ..|::|     .
  Rat  1171 PAVLATNKVLLDMAKMRPTTVENVKQIDGVSEGKAALLAPLTEVIKHFCQ---VNSVQT-----D 1227

  Fly   808 LFGSFK-SESEESNQSL--------NGFKTARQMLEENNSKLEGVPEK--LP-----------IK 850
            ||.|.| .|.||.:|.:        ........:.:|....|..:.|.  ||           :|
  Rat  1228 LFASTKPQEDEEKSQEMENKACSLPQSAAVTYALFQEKKMSLHSIAENRLLPLTAVGMHLAQAVK 1292

  Fly   851 DGEKRVLENRADSIGFT-SAREMLERSKQREGDDKSSNKLEKLGFISAR-----------EMLEK 903
            .|....:| ||   |.| ..|:::....:....:....|::.:..:...           |:||.
  Rat  1293 AGHPLDME-RA---GLTPETRKIIMDVIRNPPINSDMYKVKLIRMLVPENIDTYLIHMMIEILES 1353

  Fly   904 ----------NKLNERCL------------DKKDVKEKKLESRETKRSLQNNELQHKQEEDRKDK 946
                      :...:|||            .|:.|.|.|..|..::|.|        .|...|..
  Rat  1354 GSHGRTQPSCDSNRKRCLPSPAESCGSFKKSKEMVTETKAPSEMSQRKL--------PEWFVKGN 1410

  Fly   947 ASHRKTSKESLSNLKKEG 964
            .....|...|::..||:|
  Rat  1411 VPLAATGSSSMAKTKKKG 1428

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RecQ5	NP_729983.1	RecQ	5..447	CDD:440280	151/438 (34%)
		SMC_N	658..>963	CDD:481474	69/372 (19%)
Wrn	XP_063131309.1	None