Protein Alignment RecQ5 and Recql5

DIOPT Version :10

• Sequence 1: NP_729983.1
• Gene: RecQ5 / 39594
• FlyBaseID: FBgn0027375
• Length: 1058
• Species: Drosophila melanogaster
• Sequence 2: NP_001099323.1
• Gene: Recql5 / 287834
• RGDID: 1310823
• Length: 973
• Species: Rattus norvegicus
• Alignment Length: 1090
• Identity: 366/1090 - (33%)
• Similarity: 534/1090 - (48%)
• Gaps: 182/1090 - (16%)

  Fly     4 ESAVHEALKKHFGHSKFKSDLQEKAVKCAVKKKQDVYVSMPTGSGKSLCFQLPGLMSENQITIVF 68
            |..|...|||.||...||:.|||.|:...||..:||:|.||||:|||||:|||.::::. ||||.
  Rat    13 ERRVRSTLKKVFGFDSFKTPLQESAIMAVVKGDKDVFVCMPTGAGKSLCYQLPAVLAKG-ITIVV 76

  Fly    69 SPLLALIKDQIDHLTKLKVPADSLNSKMSTKERDRVIMDLKAVRTNLKFLYITPEQAATKFFQDL 133
            |||:|||:||:|||..|||...|||||:|.:||..::.||:..:...|.||||||.||:..||..
  Rat    77 SPLIALIQDQVDHLLALKVQVSSLNSKLSVQERKELLSDLERDKPRTKLLYITPEMAASASFQPT 141

  Fly   134 LQTLHKHNKLAYFAVDEAHCVSQWGHDFRPDYLKLGELRSKYSDVIWLALTATASREVKEDIYKQ 198
            |.:|...|.|:|..|||||||||||||||||||:||.|||:.:....:||||||:.:|:||::..
  Rat   142 LNSLLSRNLLSYLVVDEAHCVSQWGHDFRPDYLRLGALRSRLAHAPCVALTATATPQVQEDVFAA 206

  Fly   199 LRLHQPVAQFSTPSFRKNLFYDIVYKNSIEDDFQHLADFARHCLGNPKEFKDTPKPQRGCGIVYC 263
            |.|.||||.|.||.||.|||||:.:|..|.|.:.:|.||....||.    |.......|||||||
  Rat   207 LHLKQPVASFKTPCFRANLFYDVQFKELIPDVYGNLRDFCLKALGQ----KADNGSSSGCGIVYC 267

  Fly   264 RTRDQVERMAIGVTKQGIGAVAYHAGLKTGERTEVQEAWMRGDQPIICATNSFGMGVDKPSVRFV 328
            |||:..|::||.::.:|:.|.|||||||..|||:||..||....|:|.||.||||||||.:||||
  Rat   268 RTREACEQLAIELSSRGVNAKAYHAGLKASERTQVQNEWMEEKVPVIVATISFGMGVDKANVRFV 332

  Fly   329 IHWDVPQNVAAYYQESGRAGRDGLQSYCRLYYGREDVRSIRFLLQND-AHRARGRGDKELLTERA 392
            .||::.:::|.||||||||||||..|:|||||.|.|...:.||::.: |.....||:|.  :::|
  Rat   333 AHWNIAKSMAGYYQESGRAGRDGKPSWCRLYYSRNDRDQVSFLIRKELAKLQEKRGNKP--SDKA 395

  Fly   393 -IKQFEKITEFCERTTCRHKLFSDFFGDPTPDCSGQCDVCKRPKKAEKALEIFH------RLCM- 449
             :..|:.:..|||...|||...:.:|||..|.|:..||.|:.|....|.|:...      :.|:
  Rat   396 TLLAFDALVTFCEEVGCRHAAIAKYFGDAPPACAKGCDCCQSPAAIRKKLDALEHSSSWGKTCIG 460

  Fly   450 ---DDAFKSHISLQDCADLYEGGRPGIKRAAQEYAGGESGSDDDSGQSHSSMAKRA-KKESQDFI 510
               .|.|.        .:||||||.|.        ||.|..|:.||.|.......| |:|...|.
  Rat   461 PSQGDGFD--------PELYEGGRRGY--------GGFSRYDEGSGGSGDEGRDEAHKREWNLFY 509

  Fly   511 KQQFNLRKQISAARQLEQETIAQISRVRMAEATEKKIAGLQATHREKYLTALIDALKANVDKCKD 575
            ::|.:|||...|.   .:|.........:.:|:.:||..|....||..|..|.:||.:|......
  Rat   510 QRQMSLRKGKEAK---PEEFTPPGEDCPLRDASSRKIPKLTVKAREHCLRLLEEALNSNHQAAGS 571

  Fly   576 EPGQQPKSVLKYNDYEAMSVNMEYDVFRQNKVANMYRHALVKEISTIKKLTEQTKLLPLLVDYIP 640
            ..|.         |.:|.:|.:|::.||..|:.|:|:.:::|:::.|.|.::..:|..:
  Rat   572 THGA---------DLQAKAVELEHETFRSAKMVNLYKASVLKKVAEIHKASKDGQLYDM------ 621

  Fly   641 KPETSSKGAWTGGSVAYFERKLKELEEQRPQSLKEVPK-----ALKDRKGFKQENSKQTSISSFF 700
              |:|:|..   |::|       ||.|   .|..::|.     :||.::           :.:.|
  Rat   622 --ESSTKSC---GAIA-------ELLE---PSDYDIPPTSHLYSLKPKR-----------VGAGF 660

  Fly   701 KKEIKEEPIDSPIQEERVNIKSEQMDLEESTPKDIASNHVKEESVTPESSSSDRELELQPDSII- 764
            .|.      ..|.|.....:...|                 .|.:.||::   .|.|.:|...:
  Rat   661 SKG------PCPFQTATELLGKSQ-----------------TEKLAPEAA---LESEQEPSGWVC 699

  Fly   765 ----GERKFKLMSNGDGSYDTHRRKRVSHETQPKEKESIKTKSSMQHLFGSFKSESEESNQSLNG 825
                |:|....:    |..:.....|.:......||   :||.|.|   ||.|:.:.:..|.|
  Rat   700 DPQDGDRSKPCL----GYQEEAPGSRTNCGDPSPEK---RTKGSSQ---GSAKARASKRQQLL-- 752

  Fly   826 FKTARQMLEENNSKLEGVPEKLPIKDGEK--RVLENRAD----SIGFTSAREMLERSKQREGDDK 884
             .||.:                  ||.:.  |.|..|.:    :....|:.   :.|...:...|
  Rat   753 -ATAAR------------------KDSQSITRFLRQRTECPPPAASVPSSE---DASPCGDVPGK 795

  Fly   885 SSNKLEKLGFISA-------REMLEKNKLNERCLDK---KDVKEKKLESRETKRSLQNNELQHKQ 939
            .:.::...|.:.|       ||.|....|.::.|.|   ..:||.:.|.|...        |.:.
  Rat   796 CTEEVGAQGHLVAVFQTECPRERLSTCSLEDQSLPKGQPSPLKETQAEKRPRP--------QQES 852

  Fly   940 EEDRKDKASHRKTSKESLSNLKKEGSDSRVLQKDTKPETRNHQKTDVSKNVVQWLNPYYKR-KIA 1003
            :|.|..|.....|:..:|::  ...:::||.::..:.........:.:..||::|.|:||. :..
  Rat   853 QEKRAQKRLRPSTNSSALAS--DPSTENRVAREPCQLSAPGISLKEAADIVVRYLTPFYKEGRFI 915

  Fly  1004 TKELFKALAK----LLTQRICDGSLGDGDAGKCYIKETFHGLQMINNDQD 1049
            :|:|||..|:    ||.|::..|.....:| :..||:.||......::.|
  Rat   916 SKDLFKGFARHLSHLLAQKLSPGRSVKEEA-QSLIKQFFHNRARCESEAD 964

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RecQ5	NP_729983.1	RecQ	5..447	CDD:440280	224/449 (50%)
		SMC_N	658..>963	CDD:481474	61/330 (18%)
Recql5	NP_001099323.1	RecQ	12..449	CDD:440280	225/442 (51%)
		DEAH box	157..160		2/2 (100%)
		Interaction with POLR2A. /evidence=ECO:0000250	491..621		36/141 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	518..538		2/22 (9%)
		RecQ5	626..816	CDD:399738	48/273 (18%)
		Interaction with RAD51. /evidence=ECO:0000250	653..726		15/113 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	679..795		30/152 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	822..884		15/71 (21%)