DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RecQ5 and him-6

DIOPT Version :9

Sequence 1:	NP_729983.1	Gene:	RecQ5 / 39594	FlyBaseID:	FBgn0027375	Length:	1058	Species:	Drosophila melanogaster
Sequence 2:	NP_502390.2	Gene:	him-6 / 178201	WormBaseID:	WBGene00001865	Length:	988	Species:	Caenorhabditis elegans

Alignment Length:	713	Identity:	200/713 - (28%)
Similarity:	341/713 - (47%)	Gaps:	107/713 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VHEALKKHFGHSKFKSDLQEKAVKCAVKKKQDVYVSMPTGSGKSLCFQLPGLMSENQITIVFSPL 71
            :::.||..||.::|:.  ::|....:.....|.:|.||||:|||||:|||.::... :|:|.|||
Worm   235 LYDTLKSKFGFNQFRH--RQKQCILSTLMGHDTFVLMPTGAGKSLCYQLPAVILPG-VTVVVSPL 296

  Fly    72 LALIKDQIDHLTKLKVPADSLNSKMSTKERDRVIMDLKAVRTNLKFLYITPEQ-AATKFFQDLLQ 135
            .:||:||...:.:|.:..::|.:.:....::::..:|.:...::|.||:|||: :|:.....:..
Worm   297 RSLIEDQKMKMKELGIGCEALTADLGAPAQEKIYAELGSGNPSIKLLYVTPEKISASGRLNSVFF 361

  Fly   136 TLHKHNKLAYFAVDEAHCVSQWGHDFRPDYLKLGELRSKYSD--VIWLALTATASREVKEDIYKQ 198
            .||:...||.|.:|||||||||||||||||.||..||.||::  |..:||||||:.::..|....
Worm   362 DLHRRGLLARFVIDEAHCVSQWGHDFRPDYTKLSSLREKYANPPVPIIALTATATPKIVTDARDH 426

  Fly   199 LRLHQPVAQFSTPSFRKNLFYDIVYKNSIEDDFQHLADFARHCLGNPKEFKDTPKPQRGCGIVYC 263
            |:: |....|.:...|.||.||::.|             |...|.|..|......|.:. |||||
Worm   427 LKM-QNSKLFISSFVRDNLKYDLIPK-------------AARSLINVVEKMKQLYPGKS-GIVYC 476

  Fly   264 RTRDQVERMAIGVTKQGIGAVAYHAGLKTGERTEVQEAWMRGDQPIICATNSFGMGVDKPSVRFV 328
            .:|.:.|.:.:.:||.|:.|..|||||....|..||.:|:.....:||||.:||||:|||.||||
Worm   477 LSRKECETVQMMLTKAGLSAEVYHAGLNDNLRVSVQRSWIANKFDVICATIAFGMGIDKPDVRFV 541

  Fly   329 IHWDVPQNVAAYYQESGRAGRDGLQSYCRLYYGREDVRSIRFLLQNDAHRARGRGDKELLTERAI 393
            ||:.:|:::..||||:|||||||:.|||.:.|...|...:|.::: :.:...|      :....:
Worm   542 IHYSLPKSIEGYYQETGRAGRDGMPSYCLMLYSYHDSIRLRRMIE-EGNTTTG------VRSMHL 599

  Fly   394 KQFEKITEFCER-TTCRHKLFSDFFGD----------PTPDCSGQCDVCKRPKKAEKALEIFHRL 447
            ....::..:||. :.||.|:..:.||:          .||     ||:|:|.:|..:|:.:|
Worm   600 NNVLQVVAYCENVSVCRRKMLVEHFGEVYDEQSCRNSKTP-----CDICERQRKNAEAIRLF--- 656

  Fly   448 CMDDAFKSHISLQDC------------ADLYEGGRPGIKRAAQE-----------YAGGESGSDD 489
               |.....:|:..|            ::||.|..  ||::.::           |:.|:..|:.
Worm   657 ---DVSTDALSILKCLPRMQKATLKYISELYRGAL--IKKSQEQAMRLGHTKLPFYSKGQGMSEQ 716

  Fly   490 DS----------GQSHSSMAKRAKKESQDFIKQQFNLRKQISAARQLEQETIAQISRVRMAEATE 544
            |:          |..|..:.....:.:..|...:..     .|.|.|..           .:.|.
Worm   717 DALRFVRKLVIEGYIHERLYSVPNQAAAVFAYAELT-----EAGRDLAN-----------GKKTA 765

  Fly   545 KKIAGLQATHREKYLTALIDALKANVDKCKDEPGQQPKSVLKYNDYEAMSV----NMEYDVFRQN 605
            |....:....|::....||:.  :|::...:....:.:.::|:.|.....:    ::...|...:
Worm   766 KVYLHIVTCERKRKNAGLIEL--SNMNIVSEAQALKERHMVKHGDVFTRCLQDLTHLITAVAESS 828

  Fly   606 KVANMYRHALVKEISTIKKLTEQTKLLPLLVDYIPKPETSSKGAWTGGSVAYFERKLKELEEQ 668
            .::..|.....:.|..|..|..:|....|.:|.:.:.:.:..|......:|.:.:::.|.||:
Worm   829 GLSGPYSIVSREGIEQIAALLPRTNSDLLRIDSMTQIKVTKYGRLIMELLATYWKQVDEREEE 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RecQ5	NP_729983.1	RecQ	6..>442	CDD:223588	160/448 (36%)
		DEAD	37..193	CDD:278688	68/158 (43%)
		HELICc	<257..359	CDD:238034	52/101 (51%)
		RecQ_Zn_bind	364..431	CDD:292742	14/77 (18%)
him-6	NP_502390.2	RecQ	231..881	CDD:223588	197/701 (28%)
		DEAD	252..419	CDD:278688	69/167 (41%)
		HELICc	443..572	CDD:238034	62/142 (44%)
		RecQ_Zn_bind	577..643	CDD:292742	14/77 (18%)
		RQC	653..772	CDD:286470	21/142 (15%)
		HRDC	807..888	CDD:128635	11/80 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0514
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D445763at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820