DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RecQ5 and Blm

DIOPT Version :9

Sequence 1:	NP_729983.1	Gene:	RecQ5 / 39594	FlyBaseID:	FBgn0027375	Length:	1058	Species:	Drosophila melanogaster
Sequence 2:	NP_031576.4	Gene:	Blm / 12144	MGIID:	1328362	Length:	1419	Species:	Mus musculus

Alignment Length:	884	Identity:	256/884 - (28%)
Similarity:	374/884 - (42%)	Gaps:	210/884 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 HESAVHEALKKHFGHSKFKSDLQEKAVKCAVKKKQDVYVSMPTGSGKSLCFQLPGLMSENQITIV 67
            |...:.:...|.||...|::: |.:|:..|: ..:|.::.||||.|||||:|||..:|.. :|||
Mouse   662 HTKEMMKIFHKKFGLHNFRTN-QLEAINAAL-LGEDCFILMPTGGGKSLCYQLPACVSPG-VTIV 723

  Fly    68 FSPLLALIKDQIDHLTKLKVPADSLNSKMSTKERDRVIMDLKAVRTNLKFLYITPEQ-AATKFFQ 131
            .|||.:||.||:..||...:||..|....:..|...:.:.|......:|.||:|||: .|:....
Mouse   724 ISPLRSLIVDQVQKLTSFDIPATYLTGDKTDSEAANIYLQLSKKDPIIKLLYVTPEKVCASNRLI 788

  Fly   132 DLLQTLHKHNKLAYFAVDEAHCVSQWGHDFRPDYLKLGELRSKYSDVIWLALTATASREVKEDIY 196
            ..|:.|::...||.|.:||||||||||||||.||.::..||.|:..|..:||||||:..|::||.
Mouse   789 STLENLYERKLLARFVIDEAHCVSQWGHDFRQDYKRMNMLRQKFPSVPVMALTATANPRVQKDIL 853

  Fly   197 KQLRLHQPVAQFSTPSFRKNLFYDIVYKNSIEDDFQHLADFARHCLGNPKEFKDTPKPQRGCGIV 261
            .||::.:|.. ||....|.||.|.::.|...:..|..|....:|   :|.:          .||:
Mouse   854 TQLKILRPQV-FSMSFNRHNLKYYVLPKKPKKVAFDCLEWIRKH---HPYD----------SGII 904

  Fly   262 YCRTRDQVERMAIGVTKQGIGAVAYHAGLKTGERTEVQEAWMRGDQ-PIICATNSFGMGVDKPSV 325
            ||.:|.:.:.||..:.::|:.|:||||||....|.|||..|:..|. .:||||.:||||:|||.|
Mouse   905 YCLSRRECDTMADTLQREGLAALAYHAGLSDSARDEVQHKWINQDNCQVICATIAFGMGIDKPDV 969

  Fly   326 RFVIHWDVPQNVAAYYQESGRAGRDGLQSYCRLYYGREDVRSIRFLLQNDAHRARGRGDKELLT- 389
            |||||..:|:::..||||||||||||..|:|.|:|...||..::.|:..:.       |....|
Mouse   970 RFVIHASLPKSMEGYYQESGRAGRDGEISHCVLFYTYHDVTRLKRLIMMEK-------DGNYHTK 1027

  Fly   390 ERAIKQFEKITEFCER-TTCRHKLFSDFFGD---------PTPDCSGQCDVCKRPKKAEKALEIF 444
            |..:.....:..:||. |.||......:||:         ..||.|  ||.|.:.|. .|..::
Mouse  1028 ETHVNNLYSMVHYCENITECRRIQLLAYFGEKGFNPDFCKKYPDVS--CDNCCKTKD-YKTKDV- 1088

  Fly   445 HRLCMDDA------FKSHISLQDCADLYEGGRPGIKRAAQEYAGGESGSDDDSGQSHSSMAKRAK 503
                .||.      .:.|.|.....::...||..:......:.|                :|.||
Mouse  1089 ----TDDVKNIIRFVQEHSSSPGTRNIGPAGRFTLNMLVDIFLG----------------SKSAK 1133

  Fly   504 KESQDFIKQQFNLRKQISAARQLEQETIAQISRVRMAEATEKKIAGLQATHREKYLTALIDALKA 568
            .:|..|.|.....|..                    ||...||:...:....:.|:.|
Mouse  1134 VKSGIFGKGTTYSRHN--------------------AERLFKKLILDKILDEDLYINA------- 1171

  Fly   569 NVDKCKDEP------GQQPKSVLKYNDYEAMSVNMEYDVFR-QNKVANMYRHALVKEIS----TI 622
                 .|:|      |.:..|||        |.:::.|... :|..:...:.|||.::|    .:
Mouse  1172 -----NDQPIAYVMLGTKAHSVL--------SGHLKVDFMETENSSSIKKQKALVAKVSQREEVV 1223

  Fly   623 KK----LTEQTKLLPLLVDYIPKPETSSKGAWTGGSVAYFE----RKLKELEEQRPQSLKEVPKA 679
            ||    |||..|||               |...|  |.||.    ..||:|.|    ||...|:.
Mouse  1224 KKCLGELTEVCKLL---------------GKVFG--VHYFNIFNTATLKKLAE----SLSSDPEV 1267

  Fly   680 LKDRKGFKQENSKQTSISSFFKKEI-----KEEPIDSPIQEERVNIKSEQMDLEESTPKDIASNH 739
            |....|..::..::      :..|:     |......|.::.....:....|.||
Mouse  1268 LLQIDGVTEDKLEK------YGAEVIPVLQKYSEWTVPAEDGSPGARGAPEDTEE---------- 1316

  Fly   740 VKEESVTPESSSSDRELELQPDSIIGERKFKLMSNGDGSYDTHRRKRVSHETQPKEKESIKTKSS 804
              ||...|.||      ....:....|||.|.||      .||:.||              .::|
Mouse  1317 --EEEEAPVSS------HYFANQTRNERKRKKMS------ATHKPKR--------------RRTS 1353

  Fly   805 MQHLFGSFKSESEESNQSLNGFKTARQMLEENNSKLEGV 843
                :|.|:::        .|..|.|:  ..:.||..||
Mouse  1354 ----YGGFRAK--------GGSTTCRK--TTSKSKFYGV 1378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RecQ5	NP_729983.1	RecQ	6..>442	CDD:223588	169/448 (38%)
		DEAD	37..193	CDD:278688	70/156 (45%)
		HELICc	<257..359	CDD:238034	53/102 (52%)
		RecQ_Zn_bind	364..431	CDD:292742	18/77 (23%)
Blm	NP_031576.4	BLM_N	4..371	CDD:292819
		BDHCT	382..417	CDD:285334
		BDHCT_assoc	433..658	CDD:292821
		recQ_fam	668..1151	CDD:129701	183/550 (33%)
		DEAD	680..852	CDD:278688	73/174 (42%)
		HELICc	872..1003	CDD:238034	61/143 (43%)
		RecQ_Zn_bind	1008..1077	CDD:292742	18/77 (23%)
		RQC	1087..1189	CDD:214936	24/154 (16%)
		HRDC	1221..1297	CDD:128635	24/102 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0514
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D445763at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820