Protein Alignment RecQ5 and blm

DIOPT Version :10

• Sequence 1: NP_729983.1
• Gene: RecQ5 / 39594
• FlyBaseID: FBgn0027375
• Length: 1058
• Species: Drosophila melanogaster
• Sequence 2: XP_012813863.2
• Gene: blm / 100124311
• XenbaseID: XB-GENE-982561
• Length: 1368
• Species: Xenopus tropicalis
• Alignment Length: 879
• Identity: 262/879 - (29%)
• Similarity: 384/879 - (43%)
• Gaps: 196/879 - (22%)

  Fly     3 HESAVHEALKKHFGHSKFKSDLQEKAVKCAVKKKQDVYVSMPTGSGKSLCFQLPGLMSENQITIV 67
            |...:.:...|.||..:|:::..|....|.:  .:|.::.||||.|||||:||||.:|.. :|||
 Frog   605 HSKEMMKIFHKKFGLHRFRTNQLEAINACLL--GEDCFILMPTGGGKSLCYQLPGCVSPG-VTIV 666

  Fly    68 FSPLLALIKDQIDHLTKLKVPADSLNSKMSTKERDRVIMDLKAVRTNLKFLYITPEQ--AATKFF 130
            .|||.:||.||:..||.|.:||..|....:..|...:.:.|......:|.||:|||:  |:|:..
 Frog   667 ISPLRSLIVDQVQKLTSLDIPATYLTGDKTDAEAASIYLQLSKKDPIIKLLYVTPEKVCASTRLI 731

  Fly   131 QDLLQTLHKHNKLAYFAVDEAHCVSQWGHDFRPDYLKLGELRSKYSDVIWLALTATASREVKEDI 195
             ..::.|::...||.|.:|||||||||||||||||.:|..||.|:..|..:||||||:..|::||
 Frog   732 -STMENLYERQLLARFVIDEAHCVSQWGHDFRPDYKRLNMLRQKFQSVPMMALTATANPRVQKDI 795

  Fly   196 YKQLRLHQPVAQFSTPSF-RKNLFYDIVYKNSIEDDFQHLADFARHCLGNPKEFKDTPKPQRGCG 259
            ..||::.:|  |..|.|| |.||.||::.|..        ...|..|:...|::.....     |
 Frog   796 LNQLKMTKP--QIFTMSFNRDNLKYDVLPKKP--------KRVALDCVEWIKKYHPNDS-----G 845

  Fly   260 IVYCRTRDQVERMAIGVTKQGIGAVAYHAGLKTGERTEVQEAWMRGDQ-PIICATNSFGMGVDKP 323
            |:||.:|.:.:.||..:.|.|:.|:||||||....|..||..|:..|. .:||||.:||||:|||
 Frog   846 IIYCLSRHECDTMADTLQKGGLAALAYHAGLADSNRDYVQHKWINQDDCQVICATIAFGMGIDKP 910

  Fly   324 SVRFVIHWDVPQNVAAYYQESGRAGRDGLQSYCRLYYGREDVRSIRFLLQNDAHRARGRGDKELL 388
            .||:|||..:|::|..||||||||||||..|:|.|:|...||..||.|:|.:.       |....
 Frog   911 DVRYVIHASLPKSVEGYYQESGRAGRDGEISHCLLFYSYSDVTRIRRLIQMEK-------DGNSH 968

  Fly   389 TERA-IKQFEKITEFCERTT-CRHKLFSDFFGDP--TPD-CSG----QCDVCKRPKKAEKALEIF 444
            |::. ......:..:||... ||......:||:.  .|: |..    .||.|...|:
 Frog   969 TKQTHFNNLYSMVHYCENVVECRRMQLLAYFGENNFNPNFCKENTRVSCDNCLGRKE-------- 1025

  Fly   445 HRLCMDDAFKSHISLQDCADLYEGGRPGIKRAAQEYAGGESGSDDDSGQSHSSM----------- 498
                    |||.....|..:        |.|..||......|    .|:|:||.
 Frog  1026 --------FKSRNVTDDVRN--------IVRFVQENCSSARG----KGRSNSSRLTLNMMVDIFL 1070

  Fly   499 -AKRAKKESQDFIKQQFNLRKQISAARQLEQETIAQISRVRMAEATEKKIAGLQATHREKYLTAL 562
             :|.||.::..|.|.                   |..|| ..||...:|:...:....|.|:||
 Frog  1071 GSKSAKIQTGLFGKG-------------------AAYSR-HNAERLFRKLVLDRILDEELYITA- 1114

  Fly   563 IDALKANVDKCKDEPGQQPKSVL------KYNDYE-AMSVNMEYDVFRQNKVAN-MYRHALVKEI 619
            .|...|.|     :.|::.::||      ::.|.| |.|:..:    :.:.||| ..|..:||:.
 Frog  1115 NDQAVAYV-----KTGERAQAVLNGFLTVEFQDTENASSLRKQ----KASVVANTSQREEMVKKC 1170

  Fly   620 STIKKLTEQTKLLPLLVDYIPKPETSSKGAWTGGSVAYFE-------RKLKELEEQRPQSLKEVP 677
            ..  :|||..|.|..:.                 .|.||.       |::.|       ||...|
 Frog  1171 QA--ELTELCKRLGKIF-----------------GVHYFNIFNTATIRRIAE-------SLSPEP 1209

  Fly   678 KALKDRKGFKQENSKQTSISSFFKKEIKEEPIDSPIQEERVNIKSEQMD-LEESTPKDIASNHVK 741
            ..|..                          ||...:::.....:|.:| |::.:...:....:.
 Frog  1210 DVLLQ--------------------------IDGVTEDKLEKYGAELIDVLQKYSEWTLPVEDIH 1248

  Fly   742 EESVTPESSSSDRELELQPDSIIGERKFKLMSNGDGS--YDTHRRKRVSHETQPKEKESIKTK-- 802
            ::|..|.:.|:.|......|...|||       |:.|  :.|...|....:..|..::|.|.|
 Frog  1249 QKSSGPANFSARRYDSDDDDDDDGER-------GEKSSYFSTKSNKGTKRKNAPTFRKSKKRKTG 1306

  Fly   803 -----SSMQHLFGSF---KSESEESNQSLNGFKT 828
                 |..::..|||   .|.::.|:...:|.||
 Frog  1307 GDGQQSHPKNATGSFSRNNSTAKTSSSYYSGSKT 1340

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RecQ5	NP_729983.1	RecQ	5..447	CDD:440280	173/454 (38%)
		SMC_N	658..>963	CDD:481474	37/191 (19%)
blm	XP_012813863.2	BLM_N	1..336	CDD:465064
		BDHCT	341..380	CDD:462356
		recQ_fam	611..1094	CDD:129701	194/556 (35%)
		HRDC	1165..1243	CDD:128635	21/129 (16%)