DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shd and cyp27a1.2

DIOPT Version :9

Sequence 1:	NP_001261843.1	Gene:	shd / 39592	FlyBaseID:	FBgn0003388	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	XP_001334004.3	Gene:	cyp27a1.2 / 795106	ZFINID:	ZDB-GENE-081104-511	Length:	522	Species:	Danio rerio

Alignment Length:	563	Identity:	132/563 - (23%)
Similarity:	248/563 - (44%)	Gaps:	71/563 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAVILLLALALVLGCYCALHRHKLADIYLRPLLKNTLLEDF---YHAELIQPEAPKRRRRGIWDI 62
            |||...|:.|..|| :|          :|||....|.....   ..|..:..:...|:.:...|:
Zfish     1 MAVCFALSSAERLG-WC----------FLRPTAAATGFRSAAGNAAAASVSVQDGHRKLKTEADL 54

  Fly    63 PGPKRIPFLGTKWIFLLFFRRYKMTKLHEVYADLNRQYGDIVLEVMPSNVPIVHLYNRDDLEKVL 127
            |..|....|     :.:.|:.| :..:||:.....:.||.: .::...|:..:.:.:.:.||::|
Zfish    55 PEIKIFTML-----YQMLFKGY-LNSVHELQLYQKQVYGPL-WKINAGNLQGISISSVELLEELL 112

  Fly   128 KYPSKYPFRPPTEIIVMYRQSRPDRYASVGIVNEQGPMWQRLRSSLTSSITSPRVLQNFLPALNA 192
            :...|||.|   ..:.::.:.|..|..|.|...|:|..|.:||:.|...:..|:....:...:||
Zfish   113 RKDEKYPCR---GYMTLWTEHRDLRGISYGPFTEEGEKWYKLRAVLNKRMLHPKDSVQYGDVVNA 174

  Fly   193 VCDDFIELLRARRD--PDTLVVPNFEELANLMGLEAVCTLMLGRRMGFLAIDTKQPQKISQLAAA 255
            |..|||:.:...|:  |...:|.|.........||.:.:::...|:|  .::.:.|.:..:....
Zfish   175 VITDFIKRIYYLREMSPTGDLVSNLTNELYRFSLEGIASILFETRIG--CLEKEIPAETQKFINF 237

  Fly   256 VKQLFISQRDSYYGLGL-----W--KYFPTKTYRDFARAEDLIYDVISEIIDHELEELKKSAACE 313
            :.|:|.      |.:.:     |  ||||  .::.:....|.|:...:::||.::|.::|.....
Zfish   238 IAQMFT------YSMHVALLPNWTRKYFP--FWQKYIDGWDGIFKFGTKMIDMKMEAIQKRVDTN 294

  Fly   314 DDEAAGLRSIFLNILELKDLDIRDKKSAIIDFIAAGIETLANTLLFVLSSVTGDPGAMPRILSEF 378
            .|.|.   .....:|....:..:|...::.:.:.||:::.:||:|:.|..::.||.|...:..|.
Zfish   295 QDVAG---EYLTYLLSNGKISRKDVYGSVSELLLAGVDSTSNTMLWALYLLSKDPEAQETLYQEV 356

  Fly   379 CEYRDTNILQD-------ALTNATYTKACIQESYRLRPTAFCLARILEEDMELSG--YSLNAGTV 434
                 |.:|:|       .:.:..:.||.|:|:.||.|.....:|::.|...:.|  :.....|.
Zfish   357 -----TKVLKDDRIPTAEEVNSMPFLKAVIKETLRLYPVVPVNSRLIAETEVVIGEYFFPKKTTF 416

  Fly   435 VLCQNMIACHKDSNFQGAKQFTPERWI-DPATENFTVNVDNASIVVPFGVGRRSCPGKRFVEMEV 498
            .||..:|: ..:..|...::|.||||: |..|.      .|....:|||.|.|:|.|:|..|:|:
Zfish   417 TLCHYVIS-RDEKVFPEPQKFKPERWLRDGRTR------PNPFGSIPFGFGVRACVGRRIAELEM 474

  Fly   499 VLLLAKMVLAFDV---SFVKPLETEFEFLLAPKTPLSLRLSDR 538
            .|.||:::..|::   ..|..::..|..:|.|...::|...:|
Zfish   475 HLALARLIKLFEMRPDPTVGEVKANFRSVLVPNKKVNLHFVER 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shd	NP_001261843.1	p450	63..528	CDD:299894	114/486 (23%)
cyp27a1.2	XP_001334004.3	p450	66..505	CDD:278495	110/468 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820