Protein Alignment shd and cyp11a1.2

DIOPT Version :10

• Sequence 1: NP_996074.1
• Gene: shd / 39592
• FlyBaseID: FBgn0003388
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: XP_691817.1
• Gene: cyp11a1.2 / 563363
• ZFINID: ZDB-GENE-130911-1
• Length: 512
• Species: Danio rerio
• Alignment Length: 485
• Identity: 123/485 - (25%)
• Similarity: 207/485 - (42%)
• Gaps: 35/485 - (7%)

  Fly    61 DIPGPKRIPFLGTKWIFLLFFRRYKMTKLHEVYADLNRQYGDIVLEVMPSNVPIVHLYNRDDLEK 125
            :|||..|   ...|.:| .|.:...:..:|.:.......:|.|..|.: .....|::...:|...
Zfish    46 EIPGQWR---NSLKSVF-AFAKMGGLRNIHRIMVHNFNTFGPIYREKV-GFYESVNIIKPEDAAI 105

  Fly   126 VLKYPSKYPFRPPTEIIVMYRQSRPDRYASVGIVNEQGPMWQRLRSSLTSSITSPRVLQNFLPAL 190
            :.|....||.|...:....||..|..:|   |::.:.|..|:..|..|...:.||:|..||:|.|
Zfish   106 LFKAEGHYPKRLTIDAWTAYRDYRNRKY---GVLLKDGEDWKSNRIILNKEVISPKVQGNFVPLL 167

  Fly   191 NAVCDDFIELL--RARRDPDTLVVPNFEELANLMGLEAVCTLMLGRRMGFLA--IDTKQPQKISQ 251
            :.|..||:..:  :..|........:.........||:|..::.|.|:|.|.  ||....:.|..
Zfish   168 DEVGQDFVARVNKKIERSGQNQWTTDLSHELFKFALESVSAVLYGERLGLLLDYIDPDSQRFIDC 232

  Fly   252 LAAAVKQLFISQRDSYYGLGLWKYFPTKTYRDFARAEDLIYDVISEIIDHELEELKKSAACEDDE 316
            :....|   .:....|...||.:...:|.:|:...|.|.|::.....|.:...:|:|     :.|
Zfish   233 ITLMFK---TTSPMLYLPPGLLRPIRSKIWRNHVEAWDGIFNQADRCIQNIYRQLRK-----NPE 289

  Fly   317 AAG-LRSIFLNILELKDLDIRDKKSAIIDFIAAGIETLANTLLFVLSSVTGDPGAMPRILSEFCE 380
            ..| ...:..::|.|..|.|.|.|:::.:.:|.|::|.|.|||:.|..:..:|.....|.:|...
Zfish   290 GNGKYTGVLASLLMLDKLSIEDIKASVTELMAGGVDTTAITLLWTLYELARNPDLQEEIRAEISA 354

  Fly   381 YR--DTNILQDALTNATYTKACIQESYRLRPTAFCLARILEEDMELSGYSLNAGTVVLCQNMIAC 443
            .|  ....:...|......|..::|:.||.|.|..|.|.:.||:.:..|.:.|||:|.. .:.|.
Zfish   355 ARIASKGDMVQMLKMIPLVKGTLKETLRLHPVAVSLQRYITEDIVIQKYHIPAGTLVQL-GLYAM 418

  Fly   444 HKDSN-FQGAKQFTPERWIDPATENFTVNVDNASIVVPFGVGRRSCPGKRFVEMEVVLLLAKMVL 507
            .:|.. |...:|:.|.||::.....|.        .:.||.|.|.|.|:|..|.|:.|.|..|:.
Zfish   419 GRDHQVFPNPEQYLPSRWVNSQNHYFK--------SLSFGFGPRQCLGRRIAETEMQLFLIHMLE 475

  Fly   508 AFDVSFVKPLETE--FEFLLAPKTPLSLRL 535
            .|.:...:.:|.:  ||.:|.|:.|:.|.:
Zfish   476 NFRIEKQRQMEVKSMFELILLPEKPIMLTI 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
shd	NP_996074.1	CYP24A1-like	98..532	CDD:410677	114/443 (26%)
cyp11a1.2	XP_691817.1	cytochrome_P450	78..501	CDD:477761	113/443 (26%)