Protein Alignment shd and Cyp11b1

DIOPT Version :10

• Sequence 1: NP_996074.1
• Gene: shd / 39592
• FlyBaseID: FBgn0003388
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_036669.3
• Gene: Cyp11b1 / 500892
• RGDID: 2453
• Length: 499
• Species: Rattus norvegicus
• Alignment Length: 500
• Identity: 112/500 - (22%)
• Similarity: 217/500 - (43%)
• Gaps: 77/500 - (15%)

  Fly    65 PKRI-PFLG------TKWIFLLFFRRYK-----MTKLHEVYADLNRQYGDIVLEVMPSNVPIVHL 117
            ||.: ||..      .||:.::...|.:     ..::|:.:.:|..     :.........||.:
  Rat    32 PKTLKPFEAIPQYSRNKWLKMIQILREQGQENLHLEMHQAFQELGP-----IFRHSAGGAQIVSV 91

  Fly   118 YNRDDLEKVLKYPSKYPFRPPTEIIVMYRQSRPDRYASVGIVNEQGPMWQRLRSSLTSSITSPRV 182
            ...:|.||:.:..|..|.|.|.|..|.:|:.|..|.   |:....|..|:..|..|..::.||:.
  Rat    92 MLPEDAEKLHQVESILPHRMPLEPWVAHRELRGLRR---GVFLLNGADWRFNRLQLNPNMLSPKA 153

  Fly   183 LQNFLPALNAVCDDFIELLRARRDPDTLVVPNFEELANLMG--------------LEAVCTLMLG 233
            :|:|:|.::.|..||:|.|:.|.            |.|:.|              :||...::.|
  Rat   154 IQSFVPFVDVVARDFVENLKKRM------------LENVHGSMSINIQSNMFNYTMEASHFVISG 206

  Fly   234 RRMGFLAIDTKQPQKISQLAAAVKQLFISQRD-SYYGLGLWKYFPTKTYRDFARAEDLIYDVISE 297
            .|:|....|.| |:.:: ...|:..:|.|... .:....|.::..|:.:::...:.|:|.:.:::
  Rat   207 ERLGLTGHDLK-PESVT-FTHALHSMFKSTTQLMFLPKSLTRWTSTRVWKEHFDSWDIISEYVTK 269

  Fly   298 IIDH---ELEELKKSAACEDDEAAGLRSIFLNILELKDLDIRDKKSAIIDFIAAGIETLANTLLF 359
            .|.:   ||.|.::.:.....|.....::.::.:....:::          ||..::|.|.:|:.
  Rat   270 CIKNVYRELAEGRQQSWSVISEMVAQSTLSMDAIHANSMEL----------IAGSVDTTAISLVM 324

  Fly   360 VLSSVTGDPGAMPRILSEFCEYRDTNIL---QDALTNATYTKACIQESYRLRPTAFCLARILEED 421
            .|..:..:|.....:..|... .:.:|:   |.|:::....:|.::|:.||.|....:.||:..|
  Rat   325 TLFELARNPDVQQALRQESLA-AEASIVANPQKAMSDLPLLRAALKETLRLYPVGSFVERIVHSD 388

  Fly   422 MELSGYSLNAGTVVLCQNMIACHKDSNFQGAKQFTPERWIDPATENFTVNVDNASIVVPFGVGRR 486
            :.|..|.:.|||.|:..........:.|...:::.|:||:: ...:|.        .:.||.|.|
  Rat   389 LVLQNYHVPAGTFVIIYLYSMGRNPAVFPRPERYMPQRWLE-RKRSFQ--------HLAFGFGMR 444

  Fly   487 SCPGKRFVEMEVVLLLAKMVLAFDVSFVK--PLETEFEFLLAPKT 529
            .|.|:|..|:|::|||..|:..|.|..::  .::..|.|||.|.:
  Rat   445 QCLGRRLAEVEMLLLLHHMLKTFQVETLRQEDMQMVFRFLLMPSS 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
shd	NP_996074.1	CYP24A1-like	98..532	CDD:410677	103/454 (23%)
Cyp11b1	NP_036669.3	cytochrome_P450	72..495	CDD:477761	104/459 (23%)